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  • Cell Research
    Longwood Avenue Boston MA 02115 USA 3 Department of Genetics and Department of Pediatrics Harvard Medical School 200 Longwood Avenue Boston MA 02115 USA Correspondence Yi Zhang Tel 1 617 713 8666 E mail yzhang genetics med harvard edu The methylation state of the paternal genome is rapidly reprogrammed shortly after fertilization Recent studies have revealed that loss of 5 methylcytosine 5mC in zygotes correlates with appearance of 5 hydroxymethylcytosine 5hmC 5 formylcytosine 5fC and 5 carboxylcytosine 5caC This process is mediated by Tet3 and the 5mC oxidation products generated in zygotes are gradually lost during preimplantation development through a replication dependent dilution process Despite these findings the biological significance of Tet3 mediated oxidation of 5mC to 5hmC 5fC 5caC in zygotes is unknown DNA methylation plays an important role in silencing gene expression including the repression of transposable elements TEs Given that the activation of TEs during preimplantation development correlates with loss of DNA methylation it is believed that paternal DNA demethylation may have an important role in TE activation Here we examined this hypothesis and found that Tet3 mediated 5mC oxidation does not have a significant contribution to TE activation We show that the expression of LINE 1

    Original URL path: http://www.cell-research.com/arts.asp?id=73 (2016-02-14)
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  • Cell Research
    Sciences Chinese Academy of Sciences Shanghai 200032 China 2 Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA 3 Plant Molecular Biology Institute School of Life Sciences Nanjing University Nanjing 210093 China Correspondence Sheng Luan Hong Xia Zhang Tel 1 510 642 6306 86 21 54924705 E mail sluan berkeley edu hxzhang sippe ac cn Plant responses to developmental and environmental cues are often mediated by calcium Ca 2 signals that are transmitted by diverse calcium sensors The calcineurin B like CBL protein family represents calcium sensors that decode calcium signals through specific interactions with a group of CBL interacting protein kinases We report functional analysis of Arabidopsis CBL2 and CBL3 two closely related CBL members that are localized to the vacuolar membrane through the N terminal tonoplast targeting sequence While cbl2 or cbl3 single mutant did not show any phenotypic difference from the wild type the cbl2 cbl3 double mutant was stunted with leaf tip necrosis underdeveloped roots shorter siliques and fewer seeds These defects were reminiscent of those in the vha a2 vha a3 double mutant deficient in vacuolar H ATPase V ATPase Indeed the V ATPase activity was reduced in the cbl2 cbl3

    Original URL path: http://www.cell-research.com/arts.asp?id=74 (2016-02-14)
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  • Cell Research
    2 Wei Huang 1 Jun Xiang Shan 1 Mei Zhen Zhu 1 Liwen Jiang 2 Ji Ping Gao 1 and Hong Xuan Lin 1 National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research Shanghai Shanghai Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China 2 School of Life Sciences Centre for Cell and Developmental Biology Chinese University of Hong Kong Shatin New Territories Hong Kong China Correspondence Hong Xuan Lin Ji Ping Gao E mail hxlin sibs ac cn jpgao sibs ac cn Increased crop yields are required to support rapid population growth worldwide Grain weight is a key component of rice yield but the underlying molecular mechanisms that control it remain elusive Here we report the cloning and characterization of a new quantitative trait locus QTL for the control of rice grain length weight and yield This locus GL3 1 encodes a protein phosphatase kelch PPKL family Ser Thr phosphatase GL3 1 is a member of the large grain WY3 variety which is associated with weaker dephosphorylation activity than the small grain FAZ1 variety GL3 1 WY3 influences protein phosphorylation in the spikelet to accelerate cell division thereby resulting in longer grains and higher yields Further studies have shown that GL3 1 directly dephosphorylates its substrate Cyclin T1 3 which has only been rarely studied in plants The downregulation of Cyclin T1 3 in rice resulted in a shorter grain which indicates a novel function for Cyclin T in cell cycle regulation Our findings suggest a new mechanism for the regulation of grain size and yield that is driven through a novel phosphatase mediated process that affects the phosphorylation of Cyclin T1 3 during cell cycle progression and thus provide new insight

    Original URL path: http://www.cell-research.com/arts.asp?id=75 (2016-02-14)
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  • Cell Research
    Dai and Weihang Chai School of Molecular Biosciences WWAMI Medical Education Program Washington State University PO Box 1495 Spokane WA 99210 USA Correspondence Weihang Chai Tel 1 509 358 7575 E mail wchai wsu edu Telomere maintenance is critical for genome stability The newly identified Ctc1 Stn1 Ten1 complex is important for telomere maintenance though its precise role is unclear We report here that depletion of hStn1 induces catastrophic telomere shortening DNA damage response and early senescence in human somatic cells These phenotypes are likely due to the essential role of hStn1 in promoting efficient replication of lagging strand telomeric DNA Downregulation of hStn1 accumulates single stranded G rich DNA specifically at lagging strand telomeres increases telomere fragility hinders telomere DNA synthesis as well as delays and compromises telomeric C strand synthesis We further show that hStn1 deficiency leads to persistent and elevated association of DNA polymerase α polα to telomeres suggesting that hStn1 may modulate the DNA synthesis activity of polα rather than controlling the loading of polα to telomeres Additionally our data suggest that hStn1 is unlikely to be part of the telomere capping complex We propose that the hStn1 assists DNA polymerases to efficiently duplicate lagging strand

    Original URL path: http://www.cell-research.com/arts.asp?id=76 (2016-02-14)
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  • Cell Research
    3 S 1 Institute of Burn Research State Key Laboratory of Trauma Burns and Combined Injuries Southwest Hospital Chongqing Key Laboratory for Disease Proteomics Third Military Medical University Chongqing 400038 China 2 Department of Burn and Plastic Surgery Chengdu Military General Hospital Chengdu Sichuan 610083 China 3 Transplant Research Institute Beth Israel Medical Center Harvard Medical School Boston MA 02215 USA 4 Institute of Immunology Zhejiang University School of Medicine Hangzhou Zhejiang 310058 China 5 Antagen Institute for Biomedical Research Boston MA 02118 USA Correspondence Jun Wu Wenda Gao E mail junwupro1 yahoo com cn wendagao01 gmail com The regulatory activities of mouse CD4 Foxp3 T cells on various immune cells including NK cells have been well documented Under some conditions conventional CD4 Foxp3 T cells in the periphery are able to acquire inhibitory function on other T cells but their roles in controlling innate immune cells are poorly defined As a potential cellular therapy for cancer ex vivo activated CD4 Foxp3 effector T cells are often infused back in vivo to suppress tumor growth and metastasis Whether such activated T cells could affect NK cell control of tumorigenesis is unclear In the present study we found that mitogen activated CD4 Foxp3 T cells exhibited potent suppressor function on NK cell proliferation and cytotoxicity in vitro and notably facilitated B16 melanoma metastasis in vivo Suppression of NK cells by activated CD4 Foxp3 T cells is cell cell contact dependent and is mediated by Qa 1 NKG2A interaction as administration of antibodies blocking either Qa 1 or NKG2A could completely reverse this suppression and significantly inhibited otherwise facilitated melanoma metastasis Moreover activated CD4 Foxp3 cells from Qa 1 knockout mice completely lost the suppressor activity on NK cells and failed to facilitate melanoma metastasis when transferred in vivo Taken together our

    Original URL path: http://www.cell-research.com/arts.asp?id=77 (2016-02-14)
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  • Cell Research
    Wang 3 Shutong Xu 1 4 Tianlong Zhang 1 Chunguang Wang 3 Lan Bao 2 and Jianping Ding 1 1 State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 State Key Laboratory of Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 3

    Original URL path: http://www.cell-research.com/arts.asp?id=78 (2016-02-14)
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  • Cell Research
    Top 10 VOLUME 22 ISSUE 12 12 2012 1712 1715 Evidence for GAL3ST4 mutation as the potential cause of pectus excavatum Song Wu 1 2 3 4 Xiaojuan Sun 1 4 5 Weimin Zhu 1 Yi Huang 1 4 Lisha Mou 6 Mingming Liu 7 Xia Li 7 sup Feiyang Li 1 Xianxin Li 6 Yong Zhang 7 1 Shenzhen Second People s Hospital The First Affiliated Hospital of Shenzhen University Shenzhen Guangdong 518035 China 2 Institute of Immunology Zhongshan School of Medicine Sun Yat sen University Guangzhou Guangdong 510080 China 3 The Center for Cell and Gene Therapy Baylor College of Medicine Houston TX 77030 USA 4 Shenzhen Key Laboratory of Genitourinary Tumor Shenzhen Second People s Hospital Shenzhen Guangdong 518035 China 5 Shenzhen Engineering lab of Tumor Clinical Immune Gene Therapy Shenzhen Second People s Hospital Shenzhen Guangdong 518035 China 6 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics Institute of Urology Peking University Shenzhen Hospital Shenzhen PKU HKUST Medical Center Shenzhen Guangdong 518036 China 7 BGI Shenzhen Shenzhen Guangdong 518083 China 8 Shenzhen First People s Hospital Shenzhen Guangdong 518001 China Correspondence Zhiming Cai Daping Wang E mail caizhiming2000 yahoo com cn dapingwang1963 qq

    Original URL path: http://www.cell-research.com/arts.asp?id=79 (2016-02-14)
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  • Cell Research
    ISSUE 12 12 2012 1716 1720 Crystal structure of a TALE protein reveals an extended N terminal DNA binding region Haishan Gao 1 2 3 Xiaojing Wu 2 Jijie Chai 2 and Zhifu Han 2 1 School of Life Sciences Peking University Beijing 100871 China 2 School of Life Sciences Tsinghua University Beijing 100084 China 3 National Institute of Biological Sciences Beijing 102206 China Correspondence Zhifu Han Tel 86 10

    Original URL path: http://www.cell-research.com/arts.asp?id=80 (2016-02-14)
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