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  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 2 2 2010 113 115 Histone code in the cross talk during DNA damage signaling Thomas Vaissière and Zdenko Herceg Epigenetics Group International Agency for Research on Cancer IARC 150 cours Albert Thomas 69008 Lyon France Correspondence Zdenko Herceg Tel 33 4 7273 8398 33 4 7273 8329 E mail herceg iarc fr Cell Research 2010 20 113

    Original URL path: http://www.cell-research.com/arts.asp?id=569 (2016-02-14)
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  • Cell Research
    impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 2 2 2010 116 118 Novel molecular insights into the mechanism of GO removal by MutM Guo Min Li Guo Min Li Correspondence Guo Min Li Tel 859 257 7053 E mail gmli uky edu Cell Research 2010 20 116 118 doi 10 1038 cr 2010 15 published online

    Original URL path: http://www.cell-research.com/arts.asp?id=570 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 20 ISSUE 2 2 2010 119 121 Slaying RAS with a synthetic lethal weapon Archana Bommi Reddy 1 and William G Kaelin Jr 1 2 1 Department of Medical Oncology Dana Farber Cancer Institute and Harvard Medical School Boston MA 02115 USA 2 Howard Hughes Institute Chevy Chase MD 20815 USA Correspondence William G Kaelin Jr E mail William Kaelin dfci harvard edu Cell

    Original URL path: http://www.cell-research.com/arts.asp?id=571 (2016-02-14)
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  • Cell Research
    Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 2 2 2010 122 123 UnTTrapping the ends A new player in overcoming protein linked DNA damage Karim Bahmed Karin C Nitiss and John L Nitiss Molecular Pharmacology Department St Jude Children s Research Hospital 262 Danny Thomas Place Memphis TN 38105 USA Correspondence John L Nitiss Tel 901 595 2794 E mail john nitiss stjude org Cell Research 2010

    Original URL path: http://www.cell-research.com/arts.asp?id=572 (2016-02-14)
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  • Cell Research
    Street Worcester MA 01605 USA Correspondence Yong Xu Wang Tel 1 508 856 5647 E mail yongxu wang umassmed edu The nuclear receptor PPARs are fundamentally important for energy homeostasis Through their distinct yet overlapping functions and tissue distribution the PPARs regulate many aspects of energy metabolism at the transcriptional level Functional impairment or dysregulation of these receptors leads to a variety of metabolic diseases while their ligands offer many

    Original URL path: http://www.cell-research.com/arts.asp?id=573 (2016-02-14)
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  • Cell Research
    Shanghai Medical School Fudan University Shanghai 200032 China 3 School of Life Science and Technology Tongji University Shanghai 200092 China Correspondence Gang Pei Jian Zhao E mail gpei sibs ac cn jzhao sibs ac cn Dysregulation of β site APP cleaving enzyme BACE and or γ secretase leads to anomalous production of amyloid β peptide Aβ and contributes to the etiology of Alzheimer s disease AD Since these secretases mediate proteolytic processing of numerous proteins little success has been achieved to treat AD by secretase inhibitors because of inevitable undesired side effects Thus it is of importance to unravel the regulatory mechanisms of these secretases Here we show that δ opioid receptor DOR promotes the processing of Aβ precursor protein APP by BACE1 and γ secretase but not that of Notch N cadherin or APLP Further investigation reveals that DOR forms a complex with BACE1 and γ secretase and activation of DOR mediates the co endocytic sorting of the secretases receptor complex for APP endoproteolysis Dysfunction of the receptor retards the endocytosis of BACE1 and γ secretase and thus the production of Aβ Consistently knockdown or antagonization of DOR reduces secretase activities and ameliorates Aβ pathology and Aβ dependent behavioral

    Original URL path: http://www.cell-research.com/arts.asp?id=574 (2016-02-14)
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  • Cell Research
    Zhu 2 Ting Zhang 1 Qingqing Zhu 1 Kejing Zhang 1 Naihe Jing 1 and Charlie Degui Chen 2 1 Laboratory of Molecular Cell Biology Shanghai Key Laboratory of Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 2 State Key Laboratory of Molecular Biology Shanghai Key Laboratory of Molecular Andrology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China Correspondence Charlie Degui Chen Naihe Jing Tel 021 54921148 E mail cdchen sibs ac cn njing sibs ac cn Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression Here we identified KIAA1718 KDM7A as a novel histone demethylase specific for these two repressing marks Using mouse embryonic stem cells we demonstrated that KIAA1718 expression increased at the early phase of neural differentiation Knockdown of the gene blocked neural differentiation and the effect was rescued by the wild type human gene and not by a catalytically inactive mutant In addition overexpression of KIAA1718 accelerated neural differentiation We provide the evidence that the pro neural differentiation effect of

    Original URL path: http://www.cell-research.com/arts.asp?id=575 (2016-02-14)
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  • Cell Research
    University Beijing 100193 China 2 Department of Biochemistry and Molecular Biology National Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100005 China 3 State Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences 15 Datun Road Beijing 100101 China Correspondence Zhongzhou Chen Tel 86 10 62734078 E mail chenzhongzhou cau edu cn Dynamic regulation of histone methylation demethylation plays an important role during development Mutations and truncations in human plant homeodomain PHD finger protein 8 PHF8 are associated with X linked mental retardation and facial anomalies such as a long face broad nasal tip cleft lip cleft palate and large hands yet its molecular function and structural basis remain unclear Here we report the crystal structures of the catalytic core of PHF8 with or without α ketoglutarate α KG at high resolution Biochemical and structural studies reveal that PHF8 is a novel histone demethylase specific for di and mono methylated histone H3 lysine 9 H3K9me2 1 but not for H3K9me3 Our analyses also reveal how human PHF8 discriminates between methylation states and achieves sequence specificity for methylated H3K9 The in vitro demethylation assay also

    Original URL path: http://www.cell-research.com/arts.asp?id=576 (2016-02-14)
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