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  • Cell Research
    Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 3 3 2010 247 249 Hepatitis C virus Achilles heel dependence on liver specific microRNA miR 122 Kara L Norman and Peter Sarnow Department of Microbiology and Immunology Stanford University School of Medicine Stanford CA 94305 USA Correspondence Peter Sarnow Tel 650 498 7076 E mail psarnow stanford edu Cell Research 2010 20 247 249 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=554 (2016-02-14)
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  • Cell Research
    in human embryonic stem cells Jizhong Zou 1 2 Rory Cochran 3 and Linzhao Cheng 1 2 3 1 Stem Cell Program Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA 2 Division of Hematology Department of Medicine Johns Hopkins University School of Medicine Baltimore MD 21205 USA 3 Graduate Program in Cellular and Molecular Medicine Johns Hopkins University School of Medicine Baltimore MD 21205

    Original URL path: http://www.cell-research.com/arts.asp?id=555 (2016-02-14)
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  • Cell Research
    253 255 AID for reprogramming Suneet Agarwal and George Q Daley Division of Hematology Oncology Children s Hospital Boston Pediatric Oncology Dana Farber Cancer Institute Manton Center for Orphan Disease Research Harvard Stem Cell Institute Division of Hematology Brigham and Women s Hospital Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Howard Hughes Medical Institute Children s Hospital Boston 1 Blackfan Circle Boston MA 02115 USA Correspondence George

    Original URL path: http://www.cell-research.com/arts.asp?id=556 (2016-02-14)
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  • Cell Research
    1 National Centre for Biological Science TIFR Bellary Road Bangalore 560 065 Karnataka India 2 current address Molecular Pathogenesis Marty and Helen Kimmel Center for Biology and Medicine of the Skirball Institute for Biomolecular Medicine New York University School of Medicine New York NY 10016 Correspondence Satyajit Mayor Tel 91 80 2366 6420 E mail mayor ncbs res in Endocytosis occurs at the cell surface and involves internalization of the plasma membrane PM along with its constituent membrane proteins and lipids Endocytosis is involved in sampling of the extracellular milieu and also serves to regulate various processes initiated at the cell surface These include nutrient uptake signaling from cell surface receptors and many other processes essential for cell and tissue functioning in metazoans It is also central to the maintenance of PM lipid and protein homeostasis There are multiple means of internalization that operate concurrently at the cell surface With advancement in high resolution visualization techniques it is now possible to track multiple endocytic cargo at the same time revealing a remarkable diversity of endocytic processes in a single cell A combination of live cell imaging and efficient genetic manipulations has also aided in understanding the functional hierarchy of molecular

    Original URL path: http://www.cell-research.com/arts.asp?id=557 (2016-02-14)
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  • Cell Research
    Sciences and School of Life Sciences East China Normal University Shanghai 200241 China 2 Department of Urology Daping Hospital Institute of Surgical Research Third Military Medical University Chongqing 400042 China 3 Department of Genetics University of Texas MD Anderson Cancer Center Houston TX 77030 USA 4 Howard Hughes Medical Institute and University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA Correspondence Jiemin Wong Tel 021 54345013 E mail jmweng bio ecnu edu cn LSD1 KDM1 under the new nomenclature was the first identified lysine specific histone demethylase belonging to the flavin dependent amine oxidase family Here we report that AOF1 KDM1B under the new nomenclature a mammalian protein related to LSD1 also possesses histone demethylase activity with specificity for H3K4me1 and H3K4me2 Like LSD1 the highly conserved SWIRM domain is required for its enzymatic activity However AOF1 differs from LSD1 in several aspects First AOF1 does not appear to form stable protein complexes containing histone deacetylases Second AOF1 is found to localize to chromosomes during the mitotic phase of the cell cycle whereas LSD1 does not Third AOF1 represses transcription when tethered to DNA and this repression activity is independent of its demethylase activity Structural and functional

    Original URL path: http://www.cell-research.com/arts.asp?id=558 (2016-02-14)
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  • Cell Research
    and Hepatology Department of General Internal Medicine UKSH Campus Kiel 24105 Kiel Germany 3 Department of Hematology and Internal Oncology University Hospital Regensburg 93503 Regensburg Germany 4 Institute of Immunology University of Rostock 18057 Rostock Germany Correspondence Gisela Sparmann Tel 49 0 381 494 7569 E mail gisela sparmann med uni rostock de Origin and fate of pancreatic stellate cells PSCs before during and after pancreatic injury are a matter of debate The crucial role of PSCs in the pathogenesis of pancreatic fibrosis is generally accepted However the turnover of the cells remains obscure The present study addressed the issue of a potential bone marrow BM origin of PSCs We used a model of stable hematopoietic chimerism by grafting enhanced green fluorescence protein eGFP expressing BM cells after irradiation of acceptor rats Chimerism was detected by FACS analysis of eGFP positive cells in the peripheral blood Dibutyltin dichloride DBTC was used to induce acute pancreatic inflammation with subsequent recovery over 4 weeks Investigations have been focused on isolated cells to detect the resting PSC population The incidence of eGFP positive PSC obtained from the pancreas of chimeric rats was approximately 7 in healthy pancreatic tissue and increased significantly to a

    Original URL path: http://www.cell-research.com/arts.asp?id=559 (2016-02-14)
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  • Cell Research
    of Life Science and Biotechnology Shanghai Jiaotong University Shanghai 200240 China 2 Institute of Botany Chinese Academy of Sciences Beijing 100093 China 3 Bio X Research Center Key Laboratory of Genetics Development and Neuropsychiatric Diseases Ministry of Education Shanghai Jiaotong University Shanghai 200240 China Correspondence Dabing Zhang Tel 86 21 34205073 E mail zhangdb sjtu edu cn Although AGAMOUS LIKE6 AGL6 MADS box genes are ancient with wide distributions in gymnosperms and angiosperms their functions remain poorly understood Here we show the biological role of the AGL6 like gene OsMADS6 in specifying floral organ and meristem identities in rice Oryza sativa L OsMADS6 was strongly expressed in the floral meristem at early stages Subsequently OsMADS6 transcripts were mainly detectable in paleas lodicules carpels and the integument of ovule as well as in the receptacle Compared to wild type plants osmads6 mutants displayed altered palea identity extra glume like or mosaic organs abnormal carpel development and loss of floral meristem determinacy Strikingly mutation of a SEPALLATA SEP like gene OsMADS1 LHS1 enhanced the defect of osmads6 flowers and no inner floral organs or glume like structures were observed in whorls 2 and 3 of osmads1 z osmads6 1 flowers Furthermore the

    Original URL path: http://www.cell-research.com/arts.asp?id=560 (2016-02-14)
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  • Cell Research
    2 3 Karol D Mcneill 3 Mohammad Hashemi 6 Claus Kerkhoff 7 and Marek Los 8 1 Department of Biochemistry and Medical Genetics Manitoba Institute of Cell Biology CancerCare Manitoba Winnipeg Canada 2 Department of Physiology University of Manitoba Winnipeg Canada 3 Manitoba Institute of Child Health University of Manitoba Winnipeg Canada 4 Department of Biochemistry and Chemistry Center for Structural Biology Vanderbilt University Nashville TN 37232 8725 USA 5 Department of Human Anatomy and Cell Science University of Manitoba Winnipeg Canada 6 Department of Clinical Biochemistry Zahedan University of Medical Sciences Zahedan Iran 7 Institute of Immunology University of Muenster Roentgenstr 21 Muenster Germany 8 Interfaculty Institute of Biochemistry University of T黚ingen Hoppe Seyler Street 4 401B T黚ingen Germany Correspondence Claus Kerkhoff Marek Los Tel 49 7071 2974159 E mail kerkhoc uni muenster de marek los ifib uni tuebingen de The complex formed by two members of the S100 calcium binding protein family S100A8 A9 exerts apoptosis inducing activity in various cells of different origins Here we present evidence that the underlying molecular mechanisms involve both programmed cell death I PCD I apoptosis and PCD II autophagy like death Treatment of cells with S100A8 A9 caused the increase of Beclin 1 expression as well as Atg12 Atg5 formation S100A8 A9 induced cell death was partially inhibited by the specific PI3 kinase class III inhibitor 3 methyladenine 3 MA and by the vacuole H ATPase inhibitor bafilomycin A1 Baf A1 S100A8 A9 provoked the translocation of BNIP3 a BH3 only pro apoptotic Bcl2 family member to mitochondria Consistent with this finding ΔTM BNIP3 overexpression partially inhibited S100A8 A9 induced cell death decreased reactive oxygen species ROS generation and partially protected against the decrease in mitochondrial transmembrane potential in S100A8 A9 treated cells In addition either ΔTM BNIP3 overexpression or N

    Original URL path: http://www.cell-research.com/arts.asp?id=561 (2016-02-14)
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