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  • Cell Research
    Top 10 VOLUME 20 ISSUE 4 4 2010 391 393 Mcl1 becomes ubiquitin ous new opportunities to antagonize a pro survival protein Michael D Hogarty 1 2 1 Division of Oncology The Children s Hospital of Philadelphia 2 Department of Pediatrics The University of Pennsylvania School of Medicine Colket Translational Research Building Room 3020 3501 Civic Center Boulevard Philadelphia PA 19104 USA Correspondence Michael D Hogarty E mail hogartym email

    Original URL path: http://www.cell-research.com/arts.asp?id=541 (2016-02-14)
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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 4 4 2010 394 396 Mad revival of cancer Hong Liu and Hongtao Yu Department of Pharmacology Howard Hughes Medical Institute University of Texas Southwestern Medical Center at Dallas 6001 Forest Park Rd Dallas TX75390 USA Correspondence Hongtao Yu Tel 1 214 645 6161 E mail Hongtao Yu utsouthwestern edu Cell Research 2010 20 394 396 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=542 (2016-02-14)
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  • Cell Research
    s disease A pathological relationship Hyun pil Lee 1 Xiongwei Zhu 1 Gang Liu 2 Shu G Chen 1 George Perry 1 3 Mark A Smith 1 and Hyoung gon Lee 1 1 Department of Pathology Case Western Reserve University Cleveland Ohio 44106 USA 2 Department of Radiology University of Utah Salt Lake City UT USA 3 UTSA Neuroscience Institute and Department of Biology University of Texas at San Antonio

    Original URL path: http://www.cell-research.com/arts.asp?id=543 (2016-02-14)
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  • Cell Research
    expansion of unstable polyglutamine repeats in various disease proteins Although these mutant proteins are expressed ubiquitously in neuronal and non neuronal cells they cause selective degeneration of specific neuronal populations Recently increasing evidence shows that polyglutamine disease proteins also affect non neuronal cells However it remains unclear how the expression of polyglutamine proteins in non neuronal cells contributes to the course of the polyglutamine diseases Here we discuss recent findings

    Original URL path: http://www.cell-research.com/arts.asp?id=544 (2016-02-14)
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  • Cell Research
    1 3 Jing Cai 1 2 and Wen Wang 1 1 CAS Max Planck Junior Research Group State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences CAS Kunming Yunnan 650223 China 2 Graduate School of Chinese Academy Sciences Beijing 100039 China 3 Present address Division of Nutritional Sciences Cornell University Ithaca NY 14853 USA Correspondence Wen Wang Tel 86 871 5192979 E mail wwang mail kiz ac cn Recent transcription profiling studies have revealed an unexpectedly large proportion of antisense transcripts in eukaryotic genomes These antisense genes seem to regulate gene expression by interacting with sense genes Previous studies have focused on the non coding antisense genes but the possible regulatory role of the antisense protein is poorly understood In this study we found that a protein encoded by the antisense gene ADF1 acts as a transcription suppressor regulating the expression of sense gene MDF1 in Saccharomyces cerevisiae Based on the evolutionary genetic cytological and biochemical evidence we show that the protein coding sense gene MDF1 most likely originated de novo from a previously non coding sequence and can significantly suppress the mating efficiency of baker s yeast in rich medium by binding

    Original URL path: http://www.cell-research.com/arts.asp?id=545 (2016-02-14)
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  • Cell Research
    University B 9052 Zwijnaarde Belgium 3 VIB Department of Medical Protein Research B 9000 Ghent Belgium 4 epartment of Biochemistry Ghent University B 9000 Ghent Belgium Correspondence Peter Vandenabeele Tel 32 9 3313763 E mail peter vandenabeele dmbr VIB UGent be Interleukin 3 IL 3 deprivation of the mouse pro B cell line Ba F3 induces cell death that is abrogated by B cell lymphoma 2 Bcl 2 overexpression but remains unaffected by the pan caspase inhibitor carbobenzoxy valyl analyl aspartyl O methyl fluoromethylketone zVAD fmk IL 3 withdrawal causes receptor interacting protein RIP 1 cleavage into C terminal fragments of 30 and 25 kDa and only cleavage leading to the former was prevented by zVAD fmk siRNA experiments demonstrated that generation of the 25 kDa fragment was due to a Bcl 2 modulated release of the mitochondrial serine protease high temperature requirement protein A2 HtrA2 Omi Accordingly recombinant HtrA2 Omi efficiently cleaved mouse RIP1 in vitro generating fragments matching those observed in IL 3 deprived Ba F3 cells The HtrA2 Omi cleavage site in mouse RIP1 was mapped to the intermediate domain and the corresponding N and C terminal fragments were impaired in their ability to activate nuclear factor

    Original URL path: http://www.cell-research.com/arts.asp?id=546 (2016-02-14)
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  • Cell Research
    and Developmental Biology Imperial College London London UK 2 Department of Experimental Fetal Medicine Institution of Reproductive and Developmental Biology Imperial College London London UK Correspondence Malcolm G Parker Tel 44 207 594 2177 E mail m parker imperial ac uk We investigated the ability of fetal mesenchymal stem cells fMSCs to differentiate into brown and white adipocytes and compared the expression of a number of marker genes and key regulatory factors We showed that the expression of key adipocyte regulators and markers during differentiation is similar to that in other human and murine adipocyte models including induction of PPARγ2 and FABP4 Notably we found that the preadipocyte marker Pref 1 is induced early in differentiation and then declines markedly as the process continues suggesting that fMSCs first acquire preadipocyte characteristics as they commit to the adipogenic lineage prior to their differentiation into mature adipocytes After adipogenic induction some stem cell isolates differentiated into cells resembling brown adipocytes and others into white adipocytes Detailed investigation of one isolate showed that the novel brown fat determining factor PRDM16 is expressed both before and after differentiation Importantly these cells exhibited elevated basal UCP 1 expression which was dependent on the activity of

    Original URL path: http://www.cell-research.com/arts.asp?id=547 (2016-02-14)
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  • Cell Research
    Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine 225 South Chong Qing Road Shanghai 200025 China 2 State Key Laboratory of Medical Genomics Ruijin Hospital Shanghai Jiaotong University 197 Rui Jin Road II Shanghai 200025 China 3 Department of Physiology and Biophysics School of Life Sciences Fudan University Shanghai 200433 China Correspondence Xiangyin Kong Landian Hu Tel 86 21 63852639 E mail xykong sibs ac cn ldhu sibs ac cn A single mammalian transcript normally encodes one protein but the transcript of GNAS G protein α subunit contains two reading frames and produces two structurally unrelated proteins XLαs and ALEX No other confirmed GNAS like dual coding transcripts have been reported to date even though many such candidate genes have been predicted by bioinformatics analysis In this study we constructed a series of vectors to test how two protein products were translated from a single transcript in vitro The length of the ORF open reading frame position of the first AUG and the Kozak motif were found to be important factors These factors as well as 55 bp NMD nonsense mediated mRNA decay rule were used in a bioinformatics search

    Original URL path: http://www.cell-research.com/arts.asp?id=548 (2016-02-14)
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