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  • Cell Research
    Toxicology National Institute of Environmental Health Sciences Research Triangle Park NC 27709 USA 2 Laboratory of Signal Transduction National Institute of Environmental Health Sciences 111 TW Alexander Dr MD K2 08 Research Triangle Park NC 27709 2233 USA 3 Laboratory of Molecular Carcinogenesis National Institute of Environmental Health Sciences Research Triangle Park NC 27709 USA 4 Department of Dermatology Duke University Medical Center Durham NC 27710 USA Correspondence John E French Hengning Ke Tel 1 919 541 2569 1 919 684 8037 E mail french niehs nih gov hk71 notes duke edu BCL2 is best known as a multifunctional anti apoptotic protein However little is known about its role in cell adhesive and motility events Here we show that BCL2 may play a role in the regulation of cell adhesion spreading and motility When BCL2 was overexpressed in cultured murine and human cell lines cell spreading adhesion and motility were impaired Consistent with these results the loss of Bcl2 resulted in higher motility observed in Bcl2 null mouse embryonic fibroblast MEF cells compared to wild type The mechanism of BCL2 regulation of cell adhesion and motility may involve formation of a complex containing BCL2 actin and gelsolin which appears to functionally decrease the severing activity of gelsolin We have observed that the lysate from MCF 7 and NIH3T3 cells that overexpressed BCL2 enhanced actin polymerization in cell free in vitro assays Confocal immunofluorescent localization of BCL2 and F actin during spreading consistently showed that increased expression of BCL2 resulted in increased F actin polymerization Thus the formation of BCL2 and gelsolin complexes which possibly contain other proteins appears to play a critical role in the regulation of cell adhesion and migration Given the established correlation of cell motility with cancer metastasis this result may explain why the expression of BCL2

    Original URL path: http://www.cell-research.com/arts.asp?id=549 (2016-02-14)
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  • Cell Research
    2 Zhen Liu 1 2 Chunxi Wang 1 Xinjian Ge 1 2 and Qiwei Zhai 1 2 1 Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Graduate School of the Chinese Academy of Sciences Shanghai 200031 China Correspondence Qiwei Zhai Tel 86 21 5492 0903 E mail qwzhai sibs ac cn SIRT1 plays an important role in adipogenesis but how SIRT1 is regulated in adipogenesis is largely unknown In this study we show that both SIRT1 protein and mRNA levels were increased along with CCAAT enhancer binding protein α C EBPα during adipocyte differentiation C EBPα but not C EBPαp30 activated SIRT1 promoter in both HeLa cells and 3T3 L1 preadipocytes Furthermore C EBPα upregulated SIRT1 mRNA and protein levels in HeLa cells and increased SIRT1 expression in a p53 independent manner in Soas2 cells In preadipocytes ectopic expression of C EBPα upregulated SIRT1 protein level and knockdown of C EBPα led to the decrease of SIRT1 protein level Moreover by promoter deletion analysis gel shift assay and chromatin immunoprecipitation we found that C EBPα bound to the SIRT1 promoter at a consensus C EBPα

    Original URL path: http://www.cell-research.com/arts.asp?id=550 (2016-02-14)
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  • Cell Research
    Shanghai 200025 China 2 Institute for Nutritional Sciences Shanghai Institute for Biological Sciences Graduate School of CAS Chinese Academy of Sciences 319 Yue Yang Road Shanghai 200031 China 3 Institute of Health Sciences Shanghai Institute for Biological Sciences Graduate School of CAS Chinese Academy of Sciences 319 Yue Yang Road Shanghai 200031 China Correspondence Jingwu Z Zhang Tel 86 21 63848329 E mail jwzang sibs ac cn α Galactosylceramide α GC is widely known to activate invariant natural killer T iNKT cells to suppress myelin antigen specific Th1 responses protecting susceptible mice against experimental autoimmune encephalomyelitis EAE Here we demonstrate an unexpected finding that high doses of α GC exacerbated rather than ameliorated EAE Similar results were observed when MOG 35 55 specific T cells treated with high dose α GC were transferred into naïve syngeneic recipient mice Further study showed that high doses of α GC directly enhance the Th17 and Th1 response by activation of CD4 CD44 memory T cells through phosphorylation of STAT3 and activation of NF κB Unlike the activation of iNKT cells by low doses of α GC high doses of α GC directly interacted with CD1d expressed on T cells and activated Th17 and

    Original URL path: http://www.cell-research.com/arts.asp?id=551 (2016-02-14)
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  • Cell Research
    with RhoA inhibition Jianhua Zhang 1 Ying Yang 1 and Jiarui Wu 1 2 1 Key Laboratory of Systems Biology State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 2 Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science Technology of China Hefei Anhui

    Original URL path: http://www.cell-research.com/arts.asp?id=552 (2016-02-14)
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  • Cell Research
    495 498 Sua5p is required for telomere recombination in Saccharomyces cerevisiae Fei Long Meng Xiao Fen Chen Yan Hu1 Hong Bo Tang Wei Dang1 and Jin Qiu Zhou The State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Jin Qiu Zhou Tel

    Original URL path: http://www.cell-research.com/arts.asp?id=553 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=38 (2016-02-14)


  • Cell Research
    genes Jessie Colin 1 2 Domenico Libri 1 2 and Tommaso Villa 1 2 1 LEA Laboratory of Nuclear RNA metabolism Centre de G閚閠ique Mol閏ulaire C N R S FRE3144 1 av de la Terrasse 91190 Gif sur Yvette France 2 Centre for mRNP Biogenesis and Metabolism Department of Molecular Biology Aarhus University C F M鴏lers Alle Bldg 130 DK 8000 Aarhus C Denmark Correspondence Jessie Colin Tommaso Villa Tel

    Original URL path: http://www.cell-research.com/arts.asp?id=527 (2016-02-14)
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  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 5 5 2010 504 505 Fountain of Youth aged blood forming stem cells could be rejuvenated by young microenvironment Tong Yin and Linheng Li Stowers Institute for Medical Research 1000 E 50th St Kansas City MO 64110 USA Correspondence Linheng Li E mail lil stowers institute org Cell Research 2010 20 504 505 doi 10

    Original URL path: http://www.cell-research.com/arts.asp?id=529 (2016-02-14)
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