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  • Cell Research
    Albert CH Yu 4 and Jianguo Chen 1 2 1 The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education The State Key Laboratory of Bio membrane and Membrane Bio engineering College of Life Sciences Peking University Beijing 100871 China 2 The Center for Theoretical Biology Peking University Beijing 100871 China 3 Institute of Insect Sciences Zhejiang University Hangzhou 310029 China 4 Department of Neurobiology Neuroscience Research Institute School of Basic Medical Sciences The Key Laboratory for Neuroscience Ministry of Education and Ministry of Public Health Peking University Beijing 100191 China Correspondence Junlin Teng Jianguo Chen Tel 86 10 62755786 E mail junlinteng pku edu cn chenjg pku edu cn Kinesins are microtubule based motors involved in various intracellular transports Neurons flagellated cells and pigment cells have been traditionally used as model systems to study the cellular functions of kinesins Here we report silkworm posterior silkgland PSG specialized cells with an extensive endomembrane system for intracellular transport and efficient secretion of fibroin as a novel model for kinesin study To investigate kinesin driven intracellular transport in PSG cells we cloned five silkworm kinesin like proteins KLPs BmKinesin 1 BmKinesin 6 BmKinesin 7 BmKinesin 13 and BmKinesin 14A We determined their expression patterns by relative real time PCR and western blotting Immunofluorescence microscopy verified their colocalization with microtubules By combining pull down assays LC MS MS and western blotting analysis we identified many potential cargoes of BmKinesin 1 in PSG including fibroin containing granules and exuperantia associated ribonucleoprotein RNP complexes Moreover BmKinesin 13 overexpression disrupted the microtubule network in BmN cells which is consistent with a role of Kinesin 13 in regulating microtubule dynamics in other organisms On the basis of these results we concluded that PSG might have advantages in elucidating mechanisms of intracellular transport in secretory tissues

    Original URL path: http://www.cell-research.com/arts.asp?id=524 (2016-02-14)
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  • Cell Research
    Yufang Shi 2 3 4 and Randal 1 D McKinnon 1 3 1 Department of Surgery Neurosurgery UMDNJ Robert Wood Johnson Medical School 675 Hoes Lane Piscataway NJ 08854 USA 2 Department of Molecular Genetics Microbiology Immunology UMDNJ Robert Wood Johnson Medical School 675 Hoes Lane Piscataway NJ 08854 USA 3 The Cancer Institute of New Jersey 4 Key Laboratory of Stem Cell Biology Institute of Health Sciences Shanghai Institutes

    Original URL path: http://www.cell-research.com/arts.asp?id=525 (2016-02-14)
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  • Cell Research
    1 Peng Li 2 3 Lishan Wang 1 Qi Lv 1 and Tieliu Shi 1 4 1 Center for Bioinformatics and Computational Biology and The Institute of Biomedical Sciences School of Life Sciences East China Normal University 500 Dongchuan Road Shanghai 200241 China 2 College of Life Sciences The Northeast Forestry University Harbin Heilongjiang 150040 China 3 Daqing Institute of Biotechnology Northeast Forestry University Daqing Heilongjiang 163316 China 4 Shanghai

    Original URL path: http://www.cell-research.com/arts.asp?id=526 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=36 (2016-02-14)


  • Cell Research
    Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 7 7 2010 735 737 A new twist in the microRNA pathway Not Dicer but Argonaute is required for a microRNA production Gabriel D Bossé and Martin J Simard Laval University Cancer Research Centre Hôtel Dieu de Québec CHUQ Quebec City Qu閎ec G1R 2J6 Canada Correspondence Martin J Simard E mail Martin Simard crhdq ulaval ca Cell Research 2010 20

    Original URL path: http://www.cell-research.com/arts.asp?id=496 (2016-02-14)
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  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 7 7 2010 738 740 Listeria monocytogenes a bacterial pathogen to hit on the SUMO pathway Simona Citro and Susanna Chiocca European Institute of Oncology Department of Experimental Oncology IFOM IEO Campus Via Adamello 16 20139 Milan Italy Correspondence Susanna Chiocca Tel 39 02 57489835 E mail susanna chiocca ifom ieo campus it Cell Research 2010 20 738

    Original URL path: http://www.cell-research.com/arts.asp?id=497 (2016-02-14)
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  • Cell Research
    2012 impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 7 7 2010 741 744 VEGF B a thing of beauty Xuri Li National Institutes of Health National Eye Institute Rockville 20852 Maryland USA Correspondence Xuri Li E mail lixur nei nih gov Cell Research 2010 20 741 744 doi 10 1038 cr 2010 77 published online 8

    Original URL path: http://www.cell-research.com/arts.asp?id=498 (2016-02-14)
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  • Cell Research
    20 ISSUE 7 7 2010 745 747 Hematopoietic stem and progenitor cells in HIV AIDS and immune reconstitution Jielin Zhang 1 and Clyde S Crumpacker 1 2 1 Department of Medicine at Brigham and Woman s Hospital Boston MA 02115 USA 2 The Division of Infectious Diseases Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Correspondence Jielin Zhang Clyde S Crumpacker E mail jlzhang partners org

    Original URL path: http://www.cell-research.com/arts.asp?id=499 (2016-02-14)
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