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  • Cell Research
    limited regulon in Salmonella Typhimurium Inge M Thijs 1 Hui Zhao 1 Ami De Weerdt 1 Kristof Engelen 1 David De Coster 1 Geert Schoofs 1 Michael McClelland 2 Jos Vanderleyden 1 Kathleen Marchal 1 and Sigrid CJ De Keersmaecker 1 1 Centre of Microbial and Plant Genetics KU Leuven Kasteelpark Arenberg 20 3001 Leuven Belgium 2 Vaccine Research Institute of San Diego 10835 Road to the Cure San Diego

    Original URL path: http://www.cell-research.com/arts.asp?id=494 (2016-02-14)
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  • Cell Research
    Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 8 8 2010 970 970 PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis Ziqi Zhu Yanru Wang Xia Li Yiqin Wang Longyong Xu Xiang Wang Tianliang Sun Xiaobin Dong Lulu Chen Hailei Mao Yi Yu Jinsong Li Pin Adele Chen and Charlie Degui Chen Cell Research 2010 20 970 doi 10 1038 cr

    Original URL path: http://www.cell-research.com/arts.asp?id=495 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=34 (2016-02-14)


  • Cell Research
    ISSUE 9 9 2010 971 972 Tom70 imports antiviral immunity to the mitochondria Rongtuan Lin 1 2 Suzanne Paz 1 3 and John Hiscott 1 2 3 1 Terry Fox Molecular Oncology Group Lady Davis Institute for Medical Research McGill University Montreal Canada 2 Department of Medicine McGill University Montreal Canada 3 Department of Microbiology Immunology McGill University Montreal Canada Correspondence Rongtuan Lin John Hiscott E mail rongtuan lin mcgill

    Original URL path: http://www.cell-research.com/arts.asp?id=469 (2016-02-14)
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  • Cell Research
    Online Publication Current Issue Top 10 VOLUME 20 ISSUE 9 9 2010 974 976 An imprinted signature helps isolate ESC equivalent iPSCs Ernesto Lujan 1 2 and Marius Wernig 1 1 Institute for Stem Cell Biology and Regenerative Medicine Department of Pathology 2 Department of Genetics Stanford University School of Medicine 1050 Arastradero Road Palo Alto California 94304 USA Correspondence Marius Wernig E mail wernig stanford edu Cell Research 2010

    Original URL path: http://www.cell-research.com/arts.asp?id=470 (2016-02-14)
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  • Cell Research
    Key Laboratory of Bioactive Materials College of Life Sciences Nankai University 94 Weijin Road Tianjin 300071 China 2 Division of Pediatric Hematology Oncology Children s Hospital Boston and Dana Farber Cancer Institute 300 Longwood Avenue Boston MA 02115 USA 3 Department of Biological Chemistry and Molecular Pharmacology Harvard Medical School Boston MA USA 4 Division of Hematology Brigham and Women s Hospital Boston MA USA 5 Harvard Stem Cell Institute Boston MA USA 6 Howard Hughes Medical Institute Boston MA USA Correspondence Lingyi Chen George Q Daley Tel 86 22 2350 5821 1 617 919 2013 E mail lingyichen nankai edu cn george daley childrens harvard edu Through proliferation and differentiation a single cell the zygote can give rise to a complex organism composed of many types of cells Up to the eight cell embryo stage the blastomeres are morphologically identical and distributed symmetrically in the mammalian embryo Functionally in some species they are all totipotent However due to the compaction of blastomeres and the asymmetrical cell division at the late phase of the eight cell embryo the blastomeres of the morula are no longer identical During the transition from morula to blastocyst blastomeres differentiate resulting in the first cell

    Original URL path: http://www.cell-research.com/arts.asp?id=473 (2016-02-14)
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  • Cell Research
    Fei Shan and Chen Wang Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Chen Wang Tel 86 21 54921185 E mail cwang01 sibs ac cn Intracellular RNA viruses are sensed by receptors retinoic acid inducible gene 1 RIG I melanoma differentiation associated gene 5 MDA5 that trigger the formation of MAVS signal complex on mitochondria Consequently this leads to the activation of TANK binding kinase 1 TBK1 and phosphorylation of interferon regulatory factor 3 IRF3 both of which constitutively associate with cytosolic chaperone Hsp90 It remains largely unknown how MAVS activates TBK1 IRF3 In this study we identified translocases of outer membrane 70 Tom70 a mitochondrial import receptor to interact with MAVS upon RNA virus infection Ectopic expression or knockdown of Tom70 could enhance or impair IRF3 mediated gene expression respectively Mechanistically the clamp domain R192 of Tom70 interacts with the C terminal motif EEVD of Hsp90 thus recruiting TBK1 IRF3 to mitochondria Disruption of this interaction or mislocation of Tom70 sharply impairs activation of TBK1 and IRF3 Furthermore host antiviral responses are significantly boosted or crippled in the presence or absence of Tom70

    Original URL path: http://www.cell-research.com/arts.asp?id=474 (2016-02-14)
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  • Cell Research
    cell size enlargement Xin Lu 1 Xuemin Lu 1 and Yibin Kang 1 2 1 Department of Molecular Biology Princeton University Princeton Washington Road LTL 255 NJ 08544 USA 2 Breast Cancer Program The Cancer Institute of New Jersey New Brunswick NJ 08903 USA Correspondence Yibin Kang Tel 1 609 258 8834 E mail ykang princeton edu Aneuploidy is commonly observed in breast cancer and is associated with poor prognosis One frequent type of aneuploidy hypertetraploidy may derive from ploidy duplication of hyperdiploid cells However the pathological consequences of ploidy duplication in breast cancer progression have not been characterized Here we present an experimental system demonstrating spontaneous appearance of hypertetraploid cells from organ specific metastatic variants of the MDA MB 231 breast cancer cell line through ploidy duplication in vitro and in vivo The hypertetraploid progenies showed increased metastatic potential to lung and brain but not to bone which may be partially explained by the distinct capillary structures in these organs that confer differential lodging advantages to tumor cells with enlarged size Our results suggest a potential mechanistic link between ploidy duplication and enhancement of metastatic potentials as was observed in previous clinical studies of breast cancer Aneuploidy is commonly

    Original URL path: http://www.cell-research.com/arts.asp?id=475 (2016-02-14)
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