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  • Cell Research
    3 Yi Wang 4 Jun Qin 4 Lei Li 5 Weimin Gong 3 and Shilai Bao 1 1 Key Laboratory of Molecular and Developmental Biology Institute of Genetics and Developmental Biology IGDB Chinese Academy of Sciences Beijing 100101 China 2 Graduate School of the Chinese Academy of Sciences Beijing 100039 China 3 Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 4 Department of Biochemistry and Molecular Biology Baylor College of Medicine Houston Texas 77030 USA 5 Department of Experimental Radiation Oncology MD Anderson Cancer Center Houston Texas 77030 USA Correspondence Shilai Bao Tel 86 10 64889350 E mail slbao genetics ac cn Maintenance of the Golgi apparatus GA structure and function depends on Golgi matrix proteins The posttranslational modification of Golgi proteins such as phosphorylation of members of the golgin and GRASP families is important for determining Golgi architecture Some Golgi proteins including golgin 84 are also known to be methylated but the function of golgin methylation remains unclear Here we show that the protein arginine methyltransferase 5 PRMT5 localizes to the GA and forms complexes with several components involved in GA ribbon formation and vesicle tethering PRMT5 interacts with the golgin GM130 and depletion of PRMT5 causes

    Original URL path: http://www.cell-research.com/arts.asp?id=476 (2016-02-14)
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  • Cell Research
    Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China Correspondence Jinsong Li Tel 86 21 54921422 E mail jsli sibs ac cn Somatic nuclei can be reprogrammed into a pluripotent state by nuclear transfer cell fusion and expression of transcription factors However these reprogramming processes are very inefficient which has greatly hindered efforts to elucidate the underlying molecular mechanisms Here we report a new reprogramming strategy that combines the advantages of all three reprogramming methodologies into one process We injected nuclei from cumulus cells into intact MII oocytes Following activation 80 of the reconstructed embryos developed to the blastocyst stage and tetraploid 4N embryonic stem ES cell lines were generated at a rate of 30 per reconstructed oocyte We also generated triploid 3N ES cells after injection of somatic nuclei into activated oocytes 4N and 3N ES cells expressed pluripotent markers and differentiated into cell types of three embryonic germ layers in vivo Moreover all ES cells generated histocompatible differentiated cells after being engrafted in immunocompetent B6D2F1 mice showing that ES cells derived from this reprogramming strategy might serve as a source of genetically tailored tissues for transplantation Thus we have established a simple and

    Original URL path: http://www.cell-research.com/arts.asp?id=477 (2016-02-14)
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  • Cell Research
    USA Correspondence Isabelle Coppens Tel 1 443 287 1589 E mail icoppens jhsph edu Malaria parasites encounter diverse conditions as they cycle between their vertebrate host and mosquito vector Within these distinct environments the parasite undergoes drastic transformations changing both its morphology and metabolism Plasmodium species that infect mammals must first take up residence in the liver before initiating red blood cell infection Following penetration into hepatocytes the parasite converts from an invasion competent motile elongated sporozoite to a metabolically active round trophozoite Relatively little is known about the cellular events involved in sporozoite metamorphosis Our data uncover the early cellular events associated with these transformations We illustrate that the beginning of metamorphosis is marked by the disruption of the membrane cytoskeleton beneath the plasma membrane which results in a protruding area around the nucleus As this bulbous region expands the two distal ends of the sporozoite gradually retract and disappear leading to cell sphericalization This shape change is associated with major interior renovations and clearance of superfluous organelles e g micronemes involved in invasion The membrane cytoskeleton is reorganized into dense lamellar arrays within the cytoplasm and is partially expulsed by converting parasites Simultaneously micronemes are compartmentalized into large

    Original URL path: http://www.cell-research.com/arts.asp?id=478 (2016-02-14)
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  • Cell Research
    Tsai Kun Li Tel 886 2 23123456 ext 88287 88294 E mail tsaikunli ntu edu tw Recent studies have suggested an involvement of processing pathways for the initiation of cellular responses induced by topoisomerase targeting drugs Here we showed that cellular exposure to camptothecin CPT induced formation of topoisomerase I cleavable complex TOP1cc degradation of TOP1 and activation of DNA damage responses DDR Transcription and proteasome dependent proteolysis but not replication were involved in CPT induced TOP1 degradation while none of above three processing activities affected TOP1cc formation Replication and transcription initiated processing RIP and TIP of TOP1cc were identified as two independent pathways which contribute distinctly to various CPT activated DDR Specifically in cycling cells RIP processed TOP1cc triggered the CPT induced RPA phosphorylation At higher CPT dosages the TIP pathway is required for other DDR activation including ATM p53 and Chk1 2 phosphorylation The TIP pathway was further demonstrated to be S phase independent by using three nonreplicating cell models Furthermore the effect of proteasome inhibitors mimicked that of transcription inhibition on the CPT induced activation of DDR suggesting the involvement of proteasome in the TIP pathway Interestingly the TIP pathway was important for TOP1cc activated but not

    Original URL path: http://www.cell-research.com/arts.asp?id=479 (2016-02-14)
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  • Cell Research
    of mouse liver mitochondria associated miRNAs and their potential biological functions Zhen Bian 1 Li Min Li 1 Rui Tang 2 Dong Xia Hou 1 Xi Chen 1 Chen Yu Zhang 1 and Ke Zen 1 1 Jiangsu Diabetes Center State Key Laboratory of Pharmaceutical Biotechnology 2 Beihai Marine Station School of Life Sciences Nanjing University 22 Hankou Road Nanjing 210093 China Correspondence Ke Zen Chen Yu Zhang Tel 86

    Original URL path: http://www.cell-research.com/arts.asp?id=480 (2016-02-14)
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  • Cell Research
    a histone lysine demethylase with a broader specificity than its homolog in Drosophila and mammals Bo Zhou 1 2 Xiaonan Yang 1 Jianhao Jiang 1 2 Yubing Wang 1 Minghui Li 3 Muwang Li 4 Xuexia Miao 1 and Yongping Huang 1 1 Institute of Plant Physiology and Ecology Shanghai Institute for Biological Science Chinese Academy of Sciences Shanghai 200032 China 2 Graduate School of the Chinese Academy of Sciences

    Original URL path: http://www.cell-research.com/arts.asp?id=481 (2016-02-14)
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  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=33 (2016-02-14)


  • Cell Research
    Publication Current Issue Top 10 VOLUME 20 ISSUE 10 10 2010 1083 1085 New insight into cancer therapeutics Induction of differentiation by regulating the Musashi Numb Notch pathway Yoshinori Nishimoto and Hideyuki Okano Department of Physiology School of Medicine Keio University 35 Shinanomachi Shinjuku Tokyo 160 8582 Japan Correspondence Hideyuki Okano Tel 81 3 5363 3747 E mail hidokano sc itc keio ac jp hidokano a2 keio jp Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=457 (2016-02-14)
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