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  • Cell Research
    Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 10 10 2010 1086 1088 Epithelial plasticity stemness and pluripotency Oscar H Ocaña and M Angela Nieto Instituto de Neurociencias CSIC UMH Avda Ramon y Cajal s n 03550 San Juan de Alicante Spain Correspondence M Angela Nieto E mail anieto umh es Cell Research 2010 20 1086 1088 doi 10 1038 cr

    Original URL path: http://www.cell-research.com/arts.asp?id=458 (2016-02-14)
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  • Cell Research
    Online Publication Current Issue Top 10 VOLUME 20 ISSUE 10 10 2010 1089 1091 Lipid laden dendritic cells fail to function Philip C Calder Institute of Human Nutrition and Developmental Origins of Health and Disease Division School of Medicine University of Southampton Institute of Developmental Sciences Building MP887 Southampton General Hospital Tremona Road Southampton SO16 6YD United Kingdom Correspondence Philip C Calder E mail pcc soton ac uk Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=459 (2016-02-14)
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  • Cell Research
    and Pablo Menendez Andalusian Stem Cell Bank Centro de Investigacion Biomedica CSJA UGR Granada Spain Correspondence Pablo Menendez Jose L García Perez Tel 34 958 894 672 E mail pablo menendez juntadeandalucia es josel garcía perez juntadeandalucia es Here we provide data suggesting that the absence of silencing of the ectopic reprogramming factors used to reprogram somatic cells to induced pluripotent stem cells iPSCs may predispose iPSCs to genomic instability

    Original URL path: http://www.cell-research.com/arts.asp?id=460 (2016-02-14)
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  • Cell Research
    4 and Guo Ping Zhao 1 2 3 4 1 Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 2 Department of Microbiology and Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Prince of Wales Hospital Shatin New Territories Hong Kong SAR China 3 Shanghai MOST Key Laboratory of Disease and Health Genomics Chinese National Human Genome Center at Shanghai Shanghai 201203 China 4 State Key Laboratory of Genetic Engineering Department of Microbiology School of Life Sciences Fudan University Shanghai 200032 China 5 CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Correspondence Guo Ping Zhao Xiaoming Ding Shengyue Wang E mail gpzhao sibs ac cn xmding74 fudan edu cn wangsy chgc sh cn Amycolatopsis mediterranei is used for industry scale production of rifamycin which plays a vital role in antimycobacterial therapy As the first sequenced genome of the genus Amycolatopsis the chromosome of strain U32 comprising 10 236 715 base pairs is one of the largest prokaryotic genomes ever sequenced so far Unlike the linear topology found in streptomycetes this chromosome is circular particularly similar to that of Saccharopolyspora erythraea and Nocardia farcinica representing their close relationship in phylogeny and taxonomy Although the predicted 9 228 protein coding genes in the A mediterranei genome shared the greatest number of orthologs with those of S erythraea it was unexpectedly followed by Streptomyces coelicolor rather than N farcinica indicating the distinct metabolic characteristics evolved via adaptation to diverse ecological niches Besides a core region analogous to that common in streptomycetes a novel quasi core with typical core characteristics is defined within the non core region where 21 out of the total 26 gene

    Original URL path: http://www.cell-research.com/arts.asp?id=461 (2016-02-14)
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  • Cell Research
    of North Carolina at Chapel Hill Chapel Hill NC 27599 7295 USA 2 Department of Biochemistry and Biophysics Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 7295 USA 3 Current address Center for Genomic Regulation 08003 Barcelona Spain Correspondence Yi Zhang Tel 1 919 843 8225 E mail yi zhang med unc edu Once thought to be transcriptional noise large non coding RNAs lncRNAs have recently been demonstrated to be functional molecules The cell type specific expression patterns of lncRNAs suggest that their transcription may be regulated epigenetically Using a custom designed microarray here we examine the expression profile of lncRNAs in embryonic stem ES cells lineage restricted neuronal progenitor cells and terminally differentiated fibroblasts In addition we also analyze the relationship between their expression and their promoter H3K4 and H3K27 methylation patterns We find that numerous lncRNAs in these cell types undergo changes in the levels of expression and promoter H3K4me3 and H3K27me3 Interestingly lncRNAs that are expressed at lower levels in ES cells exhibit higher levels of H3K27me3 at their promoters Consistent with this result knockdown of the H3K27me3 methyltransferase Ezh2 results in derepression of these lncRNAs in ES cells Thus

    Original URL path: http://www.cell-research.com/arts.asp?id=462 (2016-02-14)
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  • Cell Research
    Wang and Lin Li State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Lin Li E mail lli sibs ac cn Dishevelled Dvl is a highly conserved protein family that plays an important role in mediating Wnt signaling from membrane to cytoplasm Recently we reported that Dvl also functions in the nucleus by stabilizing the β catenin TCFs transcriptional complex Here we describe that Dvl may function as a repressor of NF κB Our data show that Dvl directly binds to p65 and their interaction occurs in the nucleus Dvl expression inhibits p65 mediated or TNF α stimulated activation of the NF κB dependent reporter This action of Dvl however is not dependent on Wnt or its downstream effector β catenin Chromatin immunoprecipitation assay shows that recruitment of p65 to the promoters of NF κB target genes is significantly enhanced when expression of Dvl is knocked down Consistently the expression level of a subset of NF κB target genes is also increased after knock down of Dvl Moreover our data suggest that Dvl may relieve the anti apoptotic effect of NF κB thus play

    Original URL path: http://www.cell-research.com/arts.asp?id=463 (2016-02-14)
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  • Cell Research
    Danping Guan 2 Xiaoyun Hu 2 Shujian Zhao 2 Liang Li 1 Lin Zhu 1 Qiao Yan 1 Junfeng Zhang 1 Ke Zen 1 and Chen Yu Zhang 1 1 Jiangsu Diabetes Center State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University 22 Hankou Road Nanjing Jiangsu 210093 China 2 Nanjing MicroMedMark Biotech Co Ltd 88 Zhujiang Road Nanjing Jiangsu 210008 China 3 China National Institute of Standardization ZhiChun Road HaiDian District Beijing 100088 China Correspondence Chen Yu Zhang Ke Zen Junfeng Zhang E mail cyzhang nju edu cn kzen nju edu cn jfzhang nju edu cn Recent baby formula milk powder contamination incidents have shown that the classic markers or standards in milk quality control are insufficient in identifying 搈anipulated poor quality milk In the present study we demonstrated for the first time that cow milk contains large amounts of microRNAs miRNAs and that the unique expression profile of milk specific miRNAs can serve as a novel indicator and possible new standard for the quality control of raw milk and milk related commercial products such as fluid milk and powdered formula milk First using Solexa sequencing we systematically screened miRNA expression in raw milk and identified a total of 245 miRNAs in raw milk Unlike other classic biomarkers whose expression levels are nearly identical at different periods of lactation individual miRNAs can be significantly altered during lactation process implicating that miRNAs may be a more accurate indicator to reflect the quality alteration of milk Second using TaqMan probe based miRNA quantitative RT PCR we further identified seven miRNAs that have a relatively consistent expression throughout the lactation process and more importantly the expression profile of these seven milk specific miRNAs can serve as an ideal biomarker for discriminating poor quality or 搈anipulated milk from pure raw

    Original URL path: http://www.cell-research.com/arts.asp?id=464 (2016-02-14)
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  • Cell Research
    1 1 Department of Biological Chemical and Physical Sciences Illinois Institute of Technology 3101 South Dearborn Street Chicago IL 60616 USA 2 Department of Biomedical Engineering Illinois Institute of Technology 3101 South Dearborn Street Chicago IL 60616 USA Correspondence Jialing Xiang Tel 1 312 567 3491 E mail Xiang iit edu Androgen receptor AR is able to promote stress induced cell death independently of its transcription activity in androgen independent prostate cancer cells Yet the underlying mechanism is incompletely understood Here we report that stress induced proteasomal degradation of AR contributes to its pro death activity Upon exposure to ultraviolet light and staurosporine AR underwent proteasomal degradation Blockade of AR degradation significantly suppressed stress induced apoptosis in androgen independent prostate cancer cells Ectopic expression of the AR N terminal AR N domain which lacks DNA and ligand binding abilities led to cell death without any additional death stimuli Truncation analysis revealed that AR N domain contains several sub domains that regulate the pro death activity of AR specifically the first 105 amino acids which function as a minimal pro death domain acting upstream of caspases The pro apoptotic activity of AR N terminal fragments was suppressed by ectopic expression of

    Original URL path: http://www.cell-research.com/arts.asp?id=465 (2016-02-14)
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