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  • Cell Research

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    Original URL path: /artsmore1.asp?id=31 (2016-02-14)



  • Cell Research
    Current Issue Top 10 VOLUME 20 ISSUE 12 12 2010 1279 1281 IDH1 mutant structures reveal a mechanism of dominant inhibition Shimin Zhao 1 and Kun Liang Guan 2 1 School of Life Sciences Institutes for Biological Sciences Fudan University Shanghai 20032 China 2 Department of Pharmacology and Moores Cancer Center University of California San Diego La Jolla California 92093 Correspondence Kun Liang Guan E mail kuguan ucsd edu Cell

    Original URL path: http://www.cell-research.com/arts.asp?id=433 (2016-02-14)
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  • Cell Research
    Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 12 12 2010 1282 1284 Hot stuff thyroid hormones and AMPK D Grahame Hardie College of Life Sciences University of Dundee Dow Street Dundee DD1 5EH Scotland UK Correspondence D Grahame Hardie Tel 44 1382 384253 E mail d g hardie dundee ac uk Cell Research 2010 20 1282 1284 doi 10 1038 cr

    Original URL path: http://www.cell-research.com/arts.asp?id=434 (2016-02-14)
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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 20 ISSUE 12 12 2010 1285 1288 CRY links the circadian clock and CREB mediated gluconeogenesis Megumi Hatori and Satchidananda Panda The Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Correspondence Satchidananda Panda Tel 1 858 453 4100 ext 1912 E mail panda salk edu Cell Research 2010 20 1285 1288 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=435 (2016-02-14)
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  • Cell Research
    China 3 School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China 4 Graduate School of Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Correspondence Feng Shao Tel 86 10 80728593 E mail shaofeng nibs ac cn Caspase 1 mediated IL 1β production is generally controlled by two pathways Toll like receptors TLRs recognize pathogen derived products and induce NF κB dependent pro IL 1β transcription NOD like receptors NLRs assemble caspase 1 activating inflammasome complexes that sense bacterial products danger signals Through a targeted chemical screen we identify bromoxone a marine natural product as a specific and potent inhibitor of the caspase 1 pathway Bromoxone is effective over diverse inflammatory stimuli including TLR ligands plus ATP nigericin cytosolic DNA flagellin and Bacillus anthracis lethal toxin Bromoxone also efficiently suppresses caspase 1 activation triggered by several types of bacterial infection Bromoxone acts upstream or at the level of the inflammasome in a transcription independent manner Bromoxone also inhibits pro IL 1β expression by targeting components upstream of IKK in the TLR NF κB pathway The unique dual activities of bromoxone are shared by the known TAK1 inhibitor that specifically blocks Nalp3 inflammasome activation Hinted

    Original URL path: http://www.cell-research.com/arts.asp?id=436 (2016-02-14)
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  • Cell Research
    Life Sciences Tsinghua University Beijing 100084 China 2 CAS Key Laboratory of Molecular Developmental Biology and Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 3 CAS Key Laboratory for Computational Biology Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China Correspondence Ye Guang Chen Jing Dong J Han Tel 86 10 62795184 86 10 64845843 E mail ygchen tsinghua edu cn jdhan genetics ac cn Although Activin Nodal signaling regulates pluripotency of human embryonic stem ES cells how this signaling acts in mouse ES cells remains largely unclear To investigate this we confirmed that mouse ES cells possess active Smad2 mediated Activin Nodal signaling and found that Smad2 mediated Activin Nodal signaling is dispensable for self renewal maintenance but is required for proper differentiation toward the mesendoderm lineage To gain insights into the underlying mechanisms Smad2 associated genes were identified by genome wide chromatin immunoprecipitation chip analysis The results showed that there is a transcriptional correlation between Smad2 binding and Activin Nodal signaling modulation and that the development related genes were enriched among

    Original URL path: http://www.cell-research.com/arts.asp?id=437 (2016-02-14)
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  • Cell Research
    for Model Animal and Disease Study Model Animal Research Institute Nanjing University 12 Xue Fu Road Nanjing 210061 China 2 Laboratory of Vascular Biology Institute of Molecular Medicine Peking University Beijing 10087 China 3 Department of Molecular Oncology Tokyo Medical and Dental University Tokyo 113 8519 Japan Correspondence Yulong He Tel 86 25 58641512 E mail yhe20005 yahoo com Although VEGFR 3 deficiency disrupts blood vascular development during early embryogenesis the underlying mechanism was not clear To characterize its function in angiogenesis and lymphangiogenesis we employed two genetically modified mouse models in this study targeting the coding region for the ligand binding domain Vegfr3 ΔLBD or the tyrosine kinase domain with an inactivation point mutation Vegfr3 TKmut We show that lymphatic growth was disrupted in Vegfr3 ΔLBD ΔLBD and Vegfr3 TKmut TKmut mice but blood vessels developed normally in both embryo and yolk sac Interestingly in Vegfr3 ΔLBD ΔLBD but not Vegfr3 TKmut TKmut mice lymph sac was present but there was lack of lymphangiogenic sprouting We further demonstrate that both the wild type and mutant forms of VEGFR 3 could form heterodimers with VEGFR 2 and decreased the level of phospho VEGFR 2 and the downstream phospho Erk1 2

    Original URL path: http://www.cell-research.com/arts.asp?id=438 (2016-02-14)
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  • Cell Research
    Utilization Hunan Agricultural University Changsha 410128 China Correspondence Wen Hui Shen E mail wen hui shen ibmp cnrs unistra fr Polycomb group genes play crucial roles in the maintenance of the transcriptionally silenced state of genes for proper cell differentiation in animals and plants While components of the polycomb repressive complex2 PRC2 are evolutionarily conserved and their functions are extensively studied in plants PRC1 differs considerably between animals and plants and its functions in plants are as yet not well described Previous studies have identified the Arabidopsis AtRING1a and AtRING1b as homologues of the animal PRC1 subunit RING1 Here we show that the Atring1a Atring1b double mutant exhibits derepression of embryonic traits during vegetative growth Accordingly several key regulatory genes involved in embryogenesis and stem cell activity are ectopically expressed in the mutant Furthermore we show that the mutant phenotypes and increased expression of regulatory genes are enhanced by the PRC2 mutant clf Finally we show that three homologues of the animal PRC1 subunit ring finger protein BMI1 AtBMI1a AtBMI1b and AtBMI1c can bind with AtRING1a or AtRING1b and in addition AtBMI1c can bind with LHP1 The Atbmi1a Atbmi1b double mutant shows derepression of embryonic traits similar to that of

    Original URL path: http://www.cell-research.com/arts.asp?id=439 (2016-02-14)
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