archive-com.com » COM » C » CELL-RESEARCH.COM

Total: 1754

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 2 2 2011 213 216 Taming of macrophage and microglial cell activation by microRNA 124 Ashley T Conrad and Bonnie N Dittel BloodCenter of Wisconsin Blood Research Institute P O Box 2178 Milwaukee WI 53201 2178 USA Correspondence Bonnie N Dittel Tel 1 414 937 3865 E mail bonnie dittel bcw edu Cell Research 2011 21 213 216

    Original URL path: http://www.cell-research.com/arts.asp?id=401 (2016-02-14)
    Open archived version from archive

  • Cell Research
    217 219 The GTPase activating protein Rap1GAP A new player to modulate Ret signaling Gustavo Paratcha 1 2 and Fernanda Ledda 1 2 1 Division of Molecular and Cellular Neuroscience Institute of Cellular Biology and Neuroscience Prof Dr E De Robertis IBCN CONICET School of Medicine University of Buenos Aires Buenos Aires Argentina 2 Laboratory of Molecular and Cellular Neuroscience Department of Neuroscience Karolinska Institute Stockholm Sweden Correspondence Fernanda Ledda

    Original URL path: http://www.cell-research.com/arts.asp?id=402 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Zhengang Yang 1 Guo Li Ming 2 3 4 and Hongjun Song 2 3 4 1 Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China 2 Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA 3 Department of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA 4 Department of Neuroscience Johns Hopkins University School of

    Original URL path: http://www.cell-research.com/arts.asp?id=403 (2016-02-14)
    Open archived version from archive

  • Cell Research
    as a key regulator of inducible gene expression in the immune system Thus it is not surprising that the clearest biological role of NF κB is in the development and function of the immune system Both innate and adaptive immune responses as well as the development and maintenance of the cells and tissues that comprise the immune system are at multiple steps under the control of the NF κB family

    Original URL path: http://www.cell-research.com/arts.asp?id=404 (2016-02-14)
    Open archived version from archive

  • Cell Research
    to malignancy the role of mammary stem cells in development pregnancy and breast cancer Benjamin Tiede 1 and Yibin Kang 1 2 1 Department of Molecular Biology Princeton University Washington Road Princeton NJ 08544 USA 2 Breast Cancer Program Cancer Institute of New Jersey New Brunswick NJ 08903 USA Correspondence Yibin Kang Tel 1 609 258 8834 E mail ykang princeton edu Adult stem cells of the mammary gland MaSCs are a highly dynamic population of cells that are responsible for the generation of the gland during puberty and its expansion during pregnancy In recent years significant advances have been made in understanding how these cells are regulated during these developmentally important processes both in humans and in mice Understanding how MaSCs are regulated is becoming a particularly important area of research given that they may be particularly susceptible targets for transformation in breast cancer Here we summarize the identification of MaSCs how they are regulated and the evidence for their serving as the origins of breast cancer In particular we focus on how changes in MaSC populations may explain both the increased risk of developing aggressive ER PR breast cancer shortly after pregnancy and the long term decreased risk

    Original URL path: http://www.cell-research.com/arts.asp?id=405 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Medical School 1150 W Medical Center Drive Ann Arbor MI 48109 USA 3 Department of Microbiology Immunology W R Hearst Microbiology Research Center Weill Medical College of Cornell University 1300 York Avenue New York NY 10065 USA 4 Institute of Biopharmaceutical Sciences National Yang Ming University Shih Pai 112 Taipei 5 Department of Cell and Developmental Biology University of Illinois 601 South Goodwin Avenue Urbana IL 61801 USA Correspondence Ming Lei E mail leim umich edu Budding yeast Cdc13 Stn1 Ten1 CST complex plays an essential role in telomere protection and maintenance and has been proposed to be a telomere specific replication protein A RPA like complex Previous genetic and structural studies revealed a close resemblance between Stn1 Ten1 and RPA32 RPA14 However the relationship between Cdc13 and RPA70 the largest subunit of RPA has remained unclear Here we report the crystal structure of the N terminal OB oligonucleotide oligosaccharide binding fold of Cdc13 Although Cdc13 has an RPA70 like domain organization the structures of Cdc13 OB folds are significantly different from their counterparts in RPA70 suggesting that they have distinct evolutionary origins Furthermore our structural and biochemical analyses revealed unexpected dimerization by the N terminal OB fold and showed

    Original URL path: http://www.cell-research.com/arts.asp?id=406 (2016-02-14)
    Open archived version from archive

  • Cell Research
    Signaling and Cell Death Unit Department for Molecular Biomedical Research VIB Ghent Belgium 3 Molecular Signaling and Cell Death Unit Department of Biomedical Molecular Biology Ghent University Ghent Belgium 4 Microscopy Core Facility Department for Molecular Biomedical Research VIB Ghent Belgium 5 Department of Biomedical Molecular Biology Ghent University Ghent Belgium 6 University Hospital Gasthuisberg Department of Hematology Leuven Belgium Correspondence Peter Vandenabeele Jean Willems Tel 32 0 9 33 13760 32 56 246225 E mail Peter Vandenabeele dmbr vib UGent be Jean Willems kuleuven kortrijk be Neutrophil extracellular traps NETs are extracellular chromatin structures that can trap and degrade microbes They arise from neutrophils that have activated a cell death program called NET cell death or NETosis Activation of NETosis has been shown to involve NADPH oxidase activity disintegration of the nuclear envelope and most granule membranes decondensation of nuclear chromatin and formation of NETs We report that in phorbol myristate acetate PMA stimulated neutrophils intracellular chromatin decondensation and NET formation follow autophagy and superoxide production both of which are required to mediate PMA induced NETosis and occur independently of each other Neutrophils from patients with chronic granulomatous disease which lack NADPH oxidase activity still exhibit PMA induced autophagy

    Original URL path: http://www.cell-research.com/arts.asp?id=408 (2016-02-14)
    Open archived version from archive

  • Cell Research
    and Tao Xu 1 2 1 National Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China 2 College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Correspondence Tao Xu Liangyi Chen E mail xutao ibp ac cn chen liangyi yahoo com The Ca 2 release activated Ca 2 CRAC channel pore is formed by Orai1 and gated by STIM1 after intracellular Ca 2 store depletion To resolve how many STIM1 molecules are required to open a CRAC channel we fused different numbers of Orai1 subunits with functional two tandem cytoplasmic domains of STIM1 residues 336 485 designated as S domain Whole cell patch clamp recordings of these chimeric molecules revealed that CRAC current reached maximum at a stoichiometry of four Orai1 and eight S domains Further experiments indicate that two tandem S domains specifically interact with the C terminus of one Orai1 subunit and CRAC current can be gradually increased as more Orai1 subunits can interact with S domains or STIM1 proteins Our data suggest that maximal opening of one CRAC channel requires eight STIM1 molecules and support a model that the CRAC channel activation is not in an

    Original URL path: http://www.cell-research.com/arts.asp?id=409 (2016-02-14)
    Open archived version from archive



  •