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  • Cell Research
    human lung cancers Yunneng Tang Guangwen Shu Xinwang Yuan Naihe Jing and Jianguo Song Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Correspondence Jianguo Song Tel 86 21 54921167 E mail jgsong sibs ac cn The forkhead box transcription factor A2 FOXA2 is an important regulator in animal development and body homeostasis However whether FOXA2 is involved in transforming growth factor β1 TGF β1 mediated epithelial to mesenchymal transition EMT and tumor metastasis remains unknown The present study showed that in human lung cancer cell lines the abundance of FOXA2 positively correlates with epithelial phenotypes and negatively correlates with the mesenchymal phenotypes of cells and TGF β1 treatment decreased FOXA2 protein level Consistently knockdown of FOXA2 promoted EMT and invasion of lung cancer cells whereas overexpression of FOXA2 reduced the invasion and suppressed TGF β1 induced EMT In addition knockdown of FOXA2 induced slug expression and ectopic expression of FOXA2 inhibited slug transcription Furthermore we identified that FOXA2 can bind to slug promoter through a conserved binding site and that the DNA binding region and transactivation region II of FOXA2 are required for repression of

    Original URL path: http://www.cell-research.com/arts.asp?id=410 (2016-02-14)
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  • Cell Research
    Hospital Second Military Medical University 800 Xiangyin Road Shanghai 200433 China Correspondence Cheng He Tel 86 21 65515200 E mail chenghe smmu edu cn Glial cell line derived neurotrophic factor GDNF was originally recognized for its ability to promote survival of midbrain dopaminergic neurons but it has since been demonstrated to be crucial for the survival and differentiation of many neuronal subpopulations including motor neurons sympathetic neurons sensory neurons and enteric neurons To identify possible effectors or regulators of GDNF signaling we performed a yeast two hybrid screen using the intracellular domain of RET the common signaling receptor of the GDNF family as bait Using this approach we identified Rap1GAP a GTPase activating protein GAP for Rap1 as a novel RET binding protein Endogenous Rap1GAP co immunoprecipitated with RET in neural tissues and RET and Rap1GAP were co expressed in dopaminergic neurons of the mesencephalon In addition overexpression of Rap1GAP attenuated GDNF induced neurite outgrowth whereas suppressing the expression of endogenous Rap1GAP by RNAi enhanced neurite outgrowth Furthermore using co immunoprecipitation analyses we found that the interaction between RET and Rap1GAP was enhanced following GDNF treatment Mutagenesis analysis revealed that Tyr981 in the intracellular domain of RET was crucial for

    Original URL path: http://www.cell-research.com/arts.asp?id=411 (2016-02-14)
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  • Cell Research
    Brain and Cognitive Sciences McGovern Institute Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA Correspondence Zhi Qi Xiong Tel 86 21 54921720 E mail xiongzhiqi ion ac cn Research over the past decades has demonstrated that adult brain produces neural progenitor cells which proliferate and differentiate to newborn neurons that integrate into the existing circuit However detailed differentiation processes and underlying mechanisms of newly generated neurons are largely unknown due to the limitation of available methods for labeling and manipulating neural progenitor cells and newborn neurons In this study we designed a tightly controlled noninvasive system based on Cre lox P recombination to achieve long term tracing and genetic manipulation of adult neurons in vivo In this system tamoxifen inducible recombinase CreER T2 was driven by BAC based promoter of doublecortin DCX a marker of newborn neurons By crossing this Cre line with reporter mouse we found that newborn neurons in the dentate gyrus DG could be selectively pulse labeled by tamoxifen induced expression of yellow fluorescent protein YFP YFP positive neurons were identified by coimmunostaining with cell type specific markers and characterized by electrophysiological recording Furthermore analysis of the migration of these neurons showed that the

    Original URL path: http://www.cell-research.com/arts.asp?id=412 (2016-02-14)
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  • Cell Research
    of Biochemistry Hong Kong University of Science Technology Clear Water Bay Kowloon Hong Kong China 2 Model Animal Research Center Nanjing University Nanjing 201161 China 3 Current address Department of Hematology and Oncology The First Hospital Jilin University Changchun China 4 Current address Department of Molecular Biology Collage of Basic Medicine Jilin University Changchun China Correspondence Zhenguo Wu Tel 852 2358 8704 E mail bczgwu ust hk Oncostatin M OSM is a cytokine of the interleukin 6 family and plays important roles during inflammation However its roles in myoblast differentiation and muscle regeneration remain unexplored We show here that OSM potently inhibited myoblast differentiation mainly by activating the JAK1 STAT1 STAT3 pathway OSM downregulated myocyte enhancer binding factor 2A MEF2A upregulated the expression of Id1 and Id2 and inhibited the transcriptional activity of MyoD and MEF2 In addition OSM also enhanced the expression of STAT3 and OSM receptor which constituted a positive feedback loop to further amplify OSM induced signaling Moreover we found that STAT1 physically associated with MEF2 and repressed its transcriptional activity which could account for the OSM mediated repression of MEF2 Although undetectable in normal muscles in vivo OSM was rapidly induced on muscle injury and then

    Original URL path: http://www.cell-research.com/arts.asp?id=413 (2016-02-14)
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  • Cell Research
    H3K27 methylation in vivo Hui Wu 1 2 Xiuzhen Chen 2 3 Jun Xiong 1 2 Yingfeng Li 2 3 Hong Li 2 Xiaojun Ding 2 Sheng Liu 2 She Chen 2 Shaorong Gao 2 and Bing Zhu 2 1 Graduate Program Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100730 China 2 National Institute of Biological Sciences Beijing 102206 China 3 Life Science College Beijing Normal

    Original URL path: http://www.cell-research.com/arts.asp?id=414 (2016-02-14)
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  • Cell Research
    2 2 2011 368 371 Multiple death pathways in TNF treated fibroblasts RIP3 and RIP1 dependent and independent routes Duan Wu Zhang Min Zheng Jing Zhao Yuan Yue Li Zhe Huang Zhu Li and Jiahuai Han The Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 China Correspondence Jiahuai Han Tel 86 592 2187680 E mail jhan

    Original URL path: http://www.cell-research.com/arts.asp?id=415 (2016-02-14)
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  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=28 (2016-02-14)


  • Cell Research
    Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 3 3 2011 373 374 Recent progress in the epigenetics and chromatin field Yi Zhang Howard Hughes Medical Institute Dept of Biochemistry Biophysics Lineberger Comprehensive Cancer Center University of North Carolina Chapel Hill NC 27599 7295 USA E mail yi zhang med unc edu Cell Research 2011 21 373 374 doi 10 1038 cr

    Original URL path: http://www.cell-research.com/arts.asp?id=386 (2016-02-14)
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