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  • Cell Research
    615 Charles E Young Drive South Los Angeles CA 90024 USA Correspondence Kathrin Plath Tel 1 310 2068 688 E mail kplath mednet ucla edu In 2006 the wall came down that limited the experimental conversion of differentiated cells into the pluripotent state In a landmark report Shinya Yamanaka s group described that a handful of transcription factors Oct4 Sox2 Klf4 and c Myc can convert a differentiated cell back to pluripotency over the course of a few weeks thus reprograming them into induced pluripotent stem iPS cells The birth of iPS cells started off a rush among researchers to increase the efficiency of the reprogramming process to reveal the underlying mechanistic events and allowed the generation of patient and disease specific human iPS cells which have the potential to be converted into relevant specialized cell types for replacement therapies and disease modeling This review addresses the steps involved in resetting the epigenetic landscape during reprogramming Apparently defined events occur during the course of the reprogramming process Immediately upon expression of the reprogramming factors some cells start to divide faster and quickly begin to lose their differentiated cell characteristics with robust downregulation of somatic genes Only a subset of cells

    Original URL path: http://www.cell-research.com/arts.asp?id=395 (2016-02-14)
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  • Cell Research
    Bunting Blaustein Cancer Research Building Suite 541 1650 Orleans Street Baltimore MD 21231 USA Correspondence Stephen B Baylin Tel 410 955 8506 E mail sbaylin jhmi edu Cancer evolution at all stages is driven by both epigenetic abnormalities as well as genetic alterations Dysregulation of epigenetic control events may lead to abnormal patterns of DNA methylation and chromatin configurations both of which are critical contributors to the pathogenesis of cancer These epigenetic abnormalities are set and maintained by multiple protein complexes and the interplay between their individual components including DNA methylation machinery histone modifiers particularly polycomb PcG proteins and chromatin remodeling proteins Recent advances in genome wide technology have revealed that the involvement of these dysregulated epigenetic components appears to be extensive Moreover there is a growing connection between epigenetic abnormalities in cancer and concepts concerning stem like cell subpopulations as a driving force for cancer Emerging data suggest that aspects of the epigenetic landscape inherent to normal embryonic and adult stem progenitor cells may help foster under the stress of chronic inflammation or accumulating reactive oxygen species evolution of malignant subpopulations Finally understanding molecular mechanisms involved in initiation and maintenance of epigenetic abnormalities in all types of cancer has

    Original URL path: http://www.cell-research.com/arts.asp?id=396 (2016-02-14)
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  • Cell Research
    CAS All rights reserved 1001 0602 06 30 00 www nature com cr Efficient human iPS cell derivation by a non integrating plasmid from blood cells with unique epigenetic and gene expression signatures Bin Kuan Chou1 2 Prashant Mali1 3 Xiaosong Huang1 4 Zhaohui Ye1 4 Sarah N Dowey1 4 Linda MS Resar4 Chunlin Zou1 5 Y Alex Zhang5 Jay Tong6 and Linzhao Cheng1 2 4 1Stem Cell Program Institute for Cell Engineering The Johns Hopkins University School of Medicine Baltimore Maryland USA 2Graduate Program in Cellular and Molecular Medicine The Johns Hopkins University School of Medicine Baltimore Maryland USA 3Graduate Program in Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore Maryland USA 4Division of Hematology in Department of Medicine The Johns Hopkins University School of Medicine Baltimore Maryland USA 5Cell Therapy Center Xuanwu Hospital and Capital Medical University Beijing China 6AllCells LLC Emeryville California USA Correspondence Linzhao Cheng The Johns Hopkins University School of Medicine Broadway Research Building Room 747 733 N Broadway Baltimore MD 21205 Tel 410 614 6958 Fax 443 287 5611 E mail lcheng welch jhu edu These three authors contributed equally to this work Download as printable PDF file Full Text html file Search Medline for articles by Bin Kuan Chou To identify accessible and permissive human cell types for efficient derivation of induced pluripotent stem cells iPSCs we investigated epigenetic and gene expression signatures of multiple postnatal cell types such as fibroblasts and blood cells Our analysis suggested that newborn cord blood CB and adult peripheral blood PB mononuclear cells MNCs display unique signatures that are closer to iPSCs and human embryonic stem cells ESCs than age matched fibroblasts to iPSCs ESCs thus making blood MNCs an attractive cell choice for the generation of integration free iPSCs Using an improved EBNA1 OriP

    Original URL path: http://www.cell-research.com/arts.asp?id=397 (2016-02-14)
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  • Cell Research
    A Kimbrel 1 3 Eunsil Hahm 2 Jonathan N Thon 5 Wei Wang 1 Joseph E Italiano 5 Jaehyung Cho 2 and Robert Lanza 1 4 1 Stem Cell and Regenerative Medicine International 33 Locke Drive Marlborough MA 01752 USA 2 Department of Pharmacology and Anesthesiology University of Illinois at Chicago 835 South Wolcott Avenue Chicago IL 60612 USA 3 Department of Applied Bioscience Cha University Seoul Korea 4 Advanced Cell Technology 33 Locke Drive Marlborough MA 01752 USA 5 Vascular Biology Program Department of Surgery Children s Hospital and Division of Hematology Brigham and Women s Hospital Harvard Medical School 1 Blackfan Circle Boston MA 02115 USA Correspondence Shi Jiang Lu Jaehyung Cho Robert Lanza Tel 508 791 0305 ext 684 312 355 5923 508 756 1212 ext 315 E mail jlu steminternational com thromres uic edu rlanza advancedcell com Platelets play an essential role in hemostasis and atherothrombosis Owing to their short storage time there is constant demand for this life saving blood component In this study we report that it is feasible to generate functional megakaryocytes and platelets from human embryonic stem cells hESCs on a large scale Differential interference contrast and electron microscopy analyses showed that ultrastructural and morphological features of hESC derived platelets were indistinguishable from those of normal blood platelets In functional assays hESC derived platelets responded to thrombin stimulation formed microaggregates and facilitated clot formation retraction in vitro Live cell microscopy demonstrated that hESC platelets formed lamellipodia and filopodia in response to thrombin activation and tethered to each other as observed in normal blood Using real time intravital imaging with high speed video microscopy we have also shown that hESC derived platelets contribute to developing thrombi at sites of laser induced vascular injury in mice providing the first evidence for in vivo functionality

    Original URL path: http://www.cell-research.com/arts.asp?id=398 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 21 ISSUE 3 3 2011 546 549 Viable mice produced from three factor induced pluripotent stem iPS cells through tetraploid complementation Lan Kang Tong Wu Yu Tao Ye Yuan Jing He Yu Zhang Tong Luo Zhaohui Kou and Shaorong Gao National Institute of Biological Sciences Beijing 102206 China Correspondence Shaorong Gao Tel 86 10 8072 8967 E mail gaoshaorong nibs ac cn Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=399 (2016-02-14)
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  • Cell Research
    through tetraploid complementation Wei Li 1 3 Xiao yang Zhao 1 3 Hai feng Wan 1 3 Ying Zhang 1 Lei Liu 1 Zhuo Lv 1 3 Xiu Jie Wang 2 Liu Wang 1 and Qi Zhou 1 1 State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China 2 Center for Molecular Systems Biology Institute of Genetics and Developmental Biology Chinese Academy of

    Original URL path: http://www.cell-research.com/arts.asp?id=400 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=27 (2016-02-14)


  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 4 4 2011 555 557 Waste disposal in the endoplasmic reticulum ROS production and plant salt stress response Aldo Ceriotti CNR Consiglio Nazionale delle Ricerche Istituto di Biologia e Biotecnologia Agraria via Bassini 15 20133 Milano Italy Correspondence Aldo Ceriotti Tel 39 02 23699444 E mail ceriotti ibba cnr it Cell Research 2011 21 555 557 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=370 (2016-02-14)
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