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  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 4 4 2011 558 560 Mitochondrial ROS fuel the inflammasome Matthew T Sorbara 1 and Stephen E Girardin 2 1 Department of Immunology University of Toronto 2 Department of Laboratory Medicine and Pathobiology University of Toronto Correspondence Stephen E Girardin E mail stephen girardin utoronto ca Cell Research 2011 21 558 560 doi 10 1038

    Original URL path: http://www.cell-research.com/arts.asp?id=371 (2016-02-14)
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  • Cell Research
    10 VOLUME 21 ISSUE 4 4 2011 561 563 Talking to histone methylated RelA serves as a messenger Xiao Dong Yang 1 2 and Lin Feng Chen 1 1 Department of Biochemistry College of Medicine MC 714 University of Illinois at Urbana Champaign Urbana Illinois 61801 2 Current address Department of Molecular Biology University of Texas Southwestern Medical Center Dallas TX 75390 USA Correspondence Lin Feng Chen E mail lfchen

    Original URL path: http://www.cell-research.com/arts.asp?id=372 (2016-02-14)
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  • Cell Research
    Molecular Biology UT Southwestern Medical Center Dallas TX 75390 9148 USA 2 Stowers Medical Research Institute Kansas City MO 64110 USA Correspondence Bing Li Tel 1 214 648 1668 E mail Bing4 Li utsouthwestern edu Histone modifications not only play important roles in regulating chromatin structure and nuclear processes but also can be passed to daughter cells as epigenetic marks Accumulating evidence suggests that the key function of histone modifications

    Original URL path: http://www.cell-research.com/arts.asp?id=373 (2016-02-14)
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  • Cell Research
    Ji 1 and Yue Ma 1 1 National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences 15 Datun Rd Chaoyang District Beijing 100101 China 2 Institute of Biochemistry and Cell Biology Shanghai Institutes of Biological Sciences 320 Yueyang Rd Shanghai 200032 China 3 Center for Physiology and Pathophysiology Institute for Neurophysiology University of Cologne Robert Koch Str 39 50931 Cologne Germany Correspondence Yue Maa Guangju Jib E mail yuema ibp ac cn gj28 ibp ac cn Although myocyte cell transplantation studies have suggested a promising therapeutic potential for myocardial infarction a major obstacle to the development of clinical therapies for myocardial repair is the difficulties associated with obtaining relatively homogeneous ventricular myocytes for transplantation Human embryonic stem cells hESCs are a promising source of cardiomyocytes Here we report that retinoid signaling regulates the fate specification of atrial versus ventricular myocytes during cardiac differentiation of hESCs We found that both Noggin and the pan retinoic acid receptor antagonist BMS 189453 RAi significantly increased the cardiac differentiation efficiency of hESCs To investigate retinoid functions we compared Noggin RAi treated cultures with Noggin RA treated cultures Our results showed that the expression levels of the ventricular specific gene IRX 4 were radically elevated in Noggin RAi treated cultures MLC 2V another ventricular specific marker was expressed in the majority of the cardiomyocytes in Noggin RAi treated cultures but not in the cardiomyocytes of Noggin RA treated cultures Flow cytometry analysis and electrophysiological studies indicated that with 64 7 0 88 mean s e m cardiac differentiation efficiency 83 of the cardiomyocytes in Noggin RAi treated cultures had embryonic ventricular like action potentials APs With 50 7 1 76 cardiac differentiation efficiency 94 of the cardiomyocytes in Noggin RA treated cultures had embryonic atrial like APs These results were further confirmed by

    Original URL path: http://www.cell-research.com/arts.asp?id=374 (2016-02-14)
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  • Cell Research
    Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China 3 3Department of Cell Biology Harvard Medical School Boston MA 02115 USA 4 4Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences University of Science Technology of China Hefei 230027 China Correspondence Jia Rui Wu Junying Yuan Tel 86 21 54921128 E mail wujr sibs ac cn jyuan hms harvard edu Using an image based screen for small molecules that can affect Golgi morphology we identify a small molecule Sioc145 which can enlarge the Golgi compartments and promote protein secretion More importantly Sioc145 potentiates insulin secretion in a glucose dependent manner We show that Sioc145 selectively activates novel protein kinase Cs nPKCs δ and ε but not conventional PKCs cPKCs α βI and βII in INS 1E insulinoma cells In contrast PMA a non selective activator of cPKCs and nPKCs promotes insulin secretion independent of glucose concentrations Furthermore we demonstrate that Sioc145 and PMA show differential abilities in depolarizing the cell membrane and suggest that Sioc145 promotes insulin secretion in the amplifying pathway downstream of K ATP channels In pancreatic islets the

    Original URL path: http://www.cell-research.com/arts.asp?id=375 (2016-02-14)
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  • Cell Research
    Zhu 1 Lei Qian 1 Yijun Gu 1 Huimin Dai 1 Xun Xu 5 Jinqiu Zhou 2 Wen Wang 5 Chun Cui 1 4 and Lei Xiao 1 4 1 Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 The State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 3 Xiangtan Center Hospital Hunan 411100 China 4 College of Animal Sciences Zhejiang University Hangzhou 310058 China 5 CAS Max Planck Junior Research Group State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650223 China Correspondence Lei Xiao E mail leixiao sibs ac cn leixiao zju edu cn Reprogramming of somatic cells in the enucleated egg made Dolly the sheep the first successfully cloned mammal in 1996 However the mechanism of sheep somatic cell reprogramming has not yet been addressed Moreover sheep embryonic stem ES cells are still not available which limits the generation of precise gene modified sheep In this study we report that sheep somatic cells can be directly reprogrammed to induced pluripotent stem iPS cells using defined factors Oct4 Sox2 c Myc Klf4 Nanog Lin28 SV40 large T and hTERT Our observations indicated that somatic cells from sheep are more difficult to reprogram than somatic cells from other species in which iPS cells have been reported We demonstrated that sheep iPS cells express ES cell markers including alkaline phosphatase Oct4 Nanog Sox2 Rex1 stage specific embryonic antigen 1 TRA 1 60 TRA 1 81 and E cadherin Sheep iPS cells exhibited normal karyotypes and were able to differentiate into all three germ layers both in vitro and in teratomas

    Original URL path: http://www.cell-research.com/arts.asp?id=376 (2016-02-14)
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  • Cell Research
    Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 2 Department of Biologic and Materials Sciences University of Michigan School of Dentistry Ann Arbor MI 48109 USA 3 Department of Pathology Nanfang Hospital and School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 510515 China 4 Key Laboratory for Regenerative Medicine of the Ministry of Education Medical College Jinan University Guangzhou Guangdong 510632 China 5 Vascular Biology Research Institute Guangdong Pharmaceutical University Guangzhou Guangdong 510006 China Correspondence Jian Guo Geng Yan Qing Ding E mail genglab gmail com dyqsmu sina com The Slit family of guidance cues binds to Roundabout Robo receptors and modulates cell migration We report here that ectopic expression of Slit2 and Robo1 or recombinant Slit2 treatment of Robo1 expressing colorectal epithelial carcinoma cells recruited an ubiquitin ligase Hakai for E cadherin E cad ubiquitination and lysosomal degradation epithelial mesenchymal transition EMT and tumor growth and liver metastasis which were rescued by knockdown of Hakai In contrast knockdown of endogenous Robo1 or specific blockade of Slit2 binding to Robo1 prevented E cad degradation and reversed EMT resulting in diminished tumor growth and

    Original URL path: http://www.cell-research.com/arts.asp?id=377 (2016-02-14)
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  • Cell Research
    Ha Oh Tel 82 42 350 2648 E mail bhoh kaist ac kr Interactions between the BCL 2 family proteins determine the cell s fate to live or die How they interact with each other to regulate apoptosis remains as an unsettled central issue So far the antiapoptotic BCL 2 proteins are thought to interact with BAX weakly but the physiological significance of this interaction has been vague Herein we show that recombinant BCL 2 and BCL w interact potently with a BCL 2 homology BH 3 domain containing peptide derived from BAX exhibiting the dissociation constants of 15 and 23 nM respectively To clarify the basis for this strong interaction we determined the three dimensional structure of a complex of BCL 2 with a BAX peptide spanning its BH3 domain It revealed that their interactions extended beyond the canonical BH3 domain and involved three nonconserved charged residues of BAX A novel BAX variant containing the alanine substitution of these three residues had greatly impaired affinity for BCL 2 and BCL w but was otherwise indistinguishable from wild type BAX Critically the apoptotic activity of the BAX variant could not be restrained by BCL 2 and BCL w pointing that

    Original URL path: http://www.cell-research.com/arts.asp?id=378 (2016-02-14)
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