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  • Cell Research
    Academia Sinica 128 Academia Road Section 2 Nankang Taipei 115 3 Institute of Molecular Medicine National Taiwan University No 7 Chung San South Road Taipei 100 4 Institute of Molecular Biology Academia Sinica 128 Academia Road Section 2 Nankang Taipei 115 Correspondence Bon chu Chung Li Jung Juan Tel 886 2 2789 9215 886 2 27871234 E mail mbchung sinica edu tw ljjuan gate sinica edu tw Glucose regulated protein 78 GRP78 a key regulator of endoplasmic reticulum ER stress facilitates cancer cell growth and viral replication The mechanism leading to grp78 gene activation during viral infection is largely unknown In this study we show that the immediate early 1 IE1 72 protein of the human cytomegalovirus HCMV is essential for HCMV mediated GRP78 activation IE1 72 upregulated grp78 gene expression depending on the ATP binding site the zinc finger domain and the putative leucine zipper motif of IE1 72 as well as the ER stress response elements ERSEs on the grp78 promoter The purified IE1 72 protein bound to the CCAAT box within ERSE in vitro whereas deletion mutants of IE1 72 deficient in grp78 promoter stimulation failed to do so Moreover IE1 72 binding to the grp78 promoter

    Original URL path: http://www.cell-research.com/arts.asp?id=379 (2016-02-14)
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  • Cell Research
    Zhu 2 Hengxiu Yu 2 Minghong Gu 2 and Zhukuan Cheng 1 1 State Key Laboratory of Plant Genomics and Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China 2 Key Laboratory of Plant Functional Genomics of Ministry of Education Yangzhou University Yangzhou 225009 China Correspondence Zhukuan Cheng Tel 86 10 64868726 E mail zkcheng genetics ac cn The events occurring at the onset of meiosis have not been fully elucidated In the present study OsAM1 was identified in rice Oryza sativa L by map based cloning OsAM1 a homolog of Arabidopsis SWI1 and maize AM1 encodes a protein with a coiled coil domain in its central region In the Osam1 mutant pollen mother cells are arrested at leptotene showing that OsAM1 is required for the leptotene zygotene transition Immunocytological analysis revealed that OsAM1 exists as foci in early prophase I meiocytes Very faint OsREC8 foci persisted in the Osam1 mutant indicating that OsAM1 is not required for the initial meiotic recruitment of OsREC8 In the absence of OsAM1 many other critical meiotic components including PAIR2 ZEP1 and OsMER3 could not be correctly installed onto chromosomes In contrast in pair2 Osmer3

    Original URL path: http://www.cell-research.com/arts.asp?id=380 (2016-02-14)
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  • Cell Research
    1 3 Karen H Vousden 1 Owen J Sansom 1 Kevin M Ryan 1 and Michael F Olson 1 1 The Beatson Institute for Cancer Research Garscube Estate Switchback Road Glasgow G61 1BD UK 2 Current address Cancer Research Technology The Beatson Institute for Cancer Research Garscube Estate Switchback Road Glasgow G61 1BD UK 3 Current address Weatherall Institute of Molecular Medicine University of Oxford John Radcliffe Hospital Oxford OX3 9DS UK Correspondence Michael F Olson E mail m olson beatson gla ac uk The central arbiter of cell fate in response to DNA damage is p53 which regulates the expression of genes involved in cell cycle arrest survival and apoptosis Although many responses initiated by DNA damage have been characterized the role of actin cytoskeleton regulators is largely unknown We now show that RhoC and LIM kinase 2 LIMK2 are direct p53 target genes induced by genotoxic agents Although RhoC and LIMK2 have well established roles in actin cytoskeleton regulation our results indicate that activation of LIMK2 also has a pro survival function following DNA damage LIMK inhibition by siRNA mediated knockdown or selective pharmacological blockade sensitized cells to radio or chemotherapy such that treatments that were sub lethal

    Original URL path: http://www.cell-research.com/arts.asp?id=381 (2016-02-14)
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  • Cell Research
    Davy U Kombila 4 Matthias Frank 5 and Gabriele Pradel 1 1 Research Center for Infectious Diseases University of W黵zburg Josef Schneider Strasse 2 D15 97080 W黵zburg Germany 2 Department of Biology Loyola University Chicago 6525 North Sheridan Road Chicago IL 60626 USA 3 INSERM U609 Global Health Institute Wellcome Trust Centre for Molecular Parasitology Ecole Polytechnique F閐閞ale de Lausanne GHI SV EPFL Station 19 CH 1015 Lausanne Switzerland 4 Medical Research Unit Albert Schweitzer Hospital Lambar閚 Gabon 5 Institute of Tropical Medicine University of T黚ingen Wilhelmstr 27 T黚ingen 72074 Germany 6 Department of Medical Microbiology Rize University Rize 53100 Turkey Correspondence Gabriele Pradel Tel 49 931 3182174 E mail gabriele pradel uni wuerzburg de Physical contact is important for the interaction between animal cells but it can represent a major challenge for protists like malaria parasites Recently novel filamentous cell cell contacts have been identified in different types of eukaryotic cells and termed nanotubes due to their morphological appearance Nanotubes represent small dynamic membranous extensions that consist of F actin and are considered an ancient feature evolved by eukaryotic cells to establish contact for communication We here describe similar tubular structures in the malaria pathogen Plasmodium falciparum which emerge from the surfaces of the forming gametes upon gametocyte activation in the mosquito midgut The filaments can exhibit a length of 100 μm and contain the F actin isoform actin 2 They actively form within a few minutes after gametocyte activation and persist until the zygote transforms into the ookinete The filaments originate from the parasite plasma membrane are close ended and express adhesion proteins on their surfaces that are typically found in gametes like Pfs 230 Pfs 48 45 or Pfs 25 but not the zygote surface protein Pfs 28 We show that these tubular structures represent long distance

    Original URL path: http://www.cell-research.com/arts.asp?id=382 (2016-02-14)
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  • Cell Research
    Qing Zhong 1 Ying Jin Lu 1 Qiong Wang 2 Fang Xiong Zhang 1 Hua Sheng Xiao 3 Lan Bao 2 and Xu Zhang 1 1 Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China 2 Institute of Biochemistry and Cell Biology and Laboratory of Molecular Cell Biology Shanghai Institutes for Biological Sciences Chinese

    Original URL path: http://www.cell-research.com/arts.asp?id=383 (2016-02-14)
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  • Cell Research
    Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 4 4 2011 700 703 Effective gene silencing in Drosophila ovarian germline by artificial microRNAs Hailong Wangu YanJun Mu and Dahua Chen State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Datun Road Chaoyang Beijing 100101 China Correspondence Dahua Chen Tel 86 10 64807325 E mail chendh ioz ac cn Cell Research 2011 21 700

    Original URL path: http://www.cell-research.com/arts.asp?id=384 (2016-02-14)
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  • Cell Research
    EISSN 1748 7838 2012 impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 4 4 2011 704 704 Regulation and function of TPL 2 an IκB kinase regulated MAP kinase kinase kinase Thorsten Gantke Srividya Sriskantharajah and Steven C Ley Division of Immune Cell Biology National Institute for Medical Research Mill Hill London NW7 1AA UK FULL TEXT

    Original URL path: http://www.cell-research.com/arts.asp?id=385 (2016-02-14)
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  • Cell Research

    (No additional info available in detailed archive for this subpage)
    Original URL path: /artsmore1.asp?id=26 (2016-02-14)




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