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  • Cell Research
    Top 10 VOLUME 21 ISSUE 5 5 2011 705 707 p53 spreads out further suppression of EMT and stemness by activating miR 200c expression Jörg Schubert 1 and Thomas Brabletz 1 2 1 Department of Visceral Surgery University of Freiburg Medical Center 79106 Freiburg Germany 2 Comprehensive Cancer Center University of Freiburg Medical Center 79106 Freiburg Germany Correspondence Thomas Brabletz Tel 49 761 270 2577 E mail thomas brabletz uniklinik

    Original URL path: http://www.cell-research.com/arts.asp?id=355 (2016-02-14)
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  • Cell Research
    Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 5 5 2011 708 710 An emerging molecular mechanism for the neural vs mesodermal cell fate decision Roman A Li and Kate G Storey Division of Cell and Developmental Biology College of Life Sciences University of Dundee UK Correspondence Kate G Storey E mail k g storey dundee ac uk Cell Research 2011 21 708 710 doi

    Original URL path: http://www.cell-research.com/arts.asp?id=356 (2016-02-14)
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  • Cell Research
    2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 5 5 2011 711 714 New wrestling rules of anti inflammatory transrepression by oxysterol receptor LXR revealed Eckardt Treuter Center for Biosciences Department of Biosciences and Nutrition Karolinska Institutet S 14183 Stockholm Sweden Correspondence Eckardt Treuter Tel 46 8 52481060 E mail eckardt treuter ki se Cell Research 2011 21 711 714 doi 10 1038

    Original URL path: http://www.cell-research.com/arts.asp?id=357 (2016-02-14)
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  • Cell Research
    88 Stuart Street Kingston Ontario Canada K7L 3N6 2 Howard Hughes Medical Institute Department of Genetics Yale University School of Medicine Boyer Center for Molecular Medicine 295 Congress Avenue New Haven CT06536 0812 USA 3 Institute of Developmental Biology and Molecular Medicine Fudan Yale Center for Biomedical Research School of Life Science Fudan University Shanghai 200433 China Correspondence Xiaolong Yang Tian Xu Tel 613 533 6000 203 737 2623 E mail yang cliff path queensu ca tian xu yale edu How multicellular organisms control their size is a fundamental question that fascinated generations of biologists In the past 10 years tremendous progress has been made toward our understanding of the molecular mechanism underlying size control Original studies from Drosophila showed that in addition to extrinsic nutritional and hormonal cues intrinsic mechanisms also play important roles in the control of organ size during development Several novel signaling pathways such as insulin and Hippo LATS signaling pathways have been identified that control organ size by regulating cell size and or cell number through modulation of cell growth cell division and cell death Later studies using mammalian cell and mouse models also demonstrated that the signaling pathways identified in flies are also conserved

    Original URL path: http://www.cell-research.com/arts.asp?id=358 (2016-02-14)
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  • Cell Research
    Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China 2 State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China Correspondence Lin Li Xiaojiang Hao E mail lli sibs ac cn haoxj mail kib ac cn The Wnt β catenin signaling pathway is a highly conserved pathway in organism evolution and regulates many biological processes Aberrant activation of the Wnt β catenin signaling pathway is closely related to tumorigenesis In order to identify potent small molecules to treat the over activated Wnt signaling mediated cancer such as colon cancer we established a mammalian cell line based reporter gene screening system The screen revealed a diterpenoid derivative 15 oxospiramilactone NC043 that inhibits Wnt3a or LiCl stimulated Top flash reporter activity in HEK293T cells and growth of colon cancer cells SW480 and Caco 2 Treatment of SW480 cells with NC043 led to decreases in the mRNA and or protein expression of Wnt target genes Axin2 Cyclin D1 and Survivin as well as decreases in the protein levels of Cdc25c and Cdc2 NC043 did not affect the cytosol nuclear distribution and protein level of soluble β catenin but decreased

    Original URL path: http://www.cell-research.com/arts.asp?id=359 (2016-02-14)
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  • Cell Research
    Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yue Yang Road Shanghai 200031 China Correspondence Xu Zhang Tel Xu Zhang E mail xu zhang ion ac cn Stimulus induced exocytosis of large dense core vesicles LDCVs leads to discharge of neuropeptides and fusion of LDCV membranes with the plasma membrane However the contribution of LDCVs to the properties of the neuronal membrane remains largely unclear The present study found that LDCVs were associated with multiple receptors channels and signaling molecules suggesting that neuronal sensitivity is modulated by an LDCV mediated mechanism Liquid chromatography mass spectrometry combined with immunoblotting of subcellular fractions identified 298 proteins in LDCV membranes purified from the dorsal spinal cord including G protein coupled receptors G proteins and other signaling molecules ion channels and trafficking related proteins Morphological assays showed that δ opioid receptor 1 DOR1 β2 adrenergic receptor AR G αi2 voltage gated calcium channel α2δ1 subunit and P2X purinoceptor 2 were localized in substance P SP positive LDCVs in small diameter dorsal root ganglion neurons whereas β1 AR Wnt receptor frizzled 8 and dishevelled 1 were present in SP negative LDCVs Furthermore DOR1 G αi2

    Original URL path: http://www.cell-research.com/arts.asp?id=360 (2016-02-14)
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  • Cell Research
    Hong Sun Immunobiology and Cancer Research Program Oklahoma Medical Research Foundation 825 NE 13th Street Oklahoma City OK 73104 USA Correspondence Xiao Hong Sun Tel 405 271 7103 E mail sunx omrf org Notch signaling controls multiple developmental processes thus demanding versatile functions We have previously shown that this may be partly achieved by accelerating ubiquitin mediated degradation of important regulators of differentiation However the underlying mechanism was unknown We now find that Notch signaling transcriptionally activates the gene encoding ankyrin repeat SOCS box containing protein 2 Asb2 Asb2 promotes the ubiquitination of Notch targets such as E2A and Janus kinase Jak 2 and a dominant negative DN mutant of Asb2 blocks Notch induced degradation of these proteins Asb2 likely binds Jak2 directly but associates with E2A through Skp2 We next provide evidence to suggest that Asb2 bridges the formation of non canonical cullin based complexes through interaction with not only ElonginB C and Cullin Cul 5 but also the F box containing protein Skp2 which is known to associate with Skp1 and Cul1 Consistently ablating the function of Cul1 or Cul5 using DN mutants or siRNAs protected both E2A and Jak2 from Asb2 mediated or Notch induced degradation By

    Original URL path: http://www.cell-research.com/arts.asp?id=361 (2016-02-14)
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  • Cell Research
    of Zoology Chinese Academy of Sciences 1st Beichen West Road Beijing 100101 China 2 Graduate School Chinese Academy of Sciences Beijing 100049 China Correspondence Qi Zhou Tel 86 10 64807299 E mail qzhou ioz ac cn Mouse cloning from fertilized eggs can assist development of approaches for the production of 揼enetically tailored human embryonic stem ES cell lines that are not constrained by the limitations of oocyte availability However to date only zygotes have been successfully used as recipients of nuclei from terminally differentiated somatic cell donors leading to ES cell lines In fertility clinics embryos of advanced embryonic stages are usually stored for future use but their ability to support the derivation of ES cell lines via somatic nuclear transfer has not yet been proved Here we report that two cell stage electrofused mouse embryos arrested in mitosis can support developmental reprogramming of nuclei from donor cells ranging from blastomeres to somatic cells Live full term cloned pups from embryonic donors as well as pluripotent ES cell lines from embryonic or somatic donors were successfully generated from these reconstructed embryos Advanced stage pre implantation embryos were unable to develop normally to term after electrofusion and transfer of a somatic

    Original URL path: http://www.cell-research.com/arts.asp?id=362 (2016-02-14)
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