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  • Cell Research
    Xiaoli Deng Juanjuan Li Miao Wang Qian Li Wei An Deli A and Yu Sheng Cong Key Lab of Cell Proliferation and Regulation Biology of the Ministry of Education Institute of Cell Biology Beijing Normal University 19 Xin Jie Kou Wai Avenue Beijing 100875 China Correspondence Yu Sheng Cong Tel 86 10 5880 2030 E mail yscong bnu edu cn Polymerase I and transcript release factor PTRF also known as Cavin 1 is an essential component in the biogenesis and function of caveolae Here we show that PTRF expression is increased in senescent human fibroblasts Importantly overexpression of PTRF induced features characteristic of cellular senescence whereas reduced PTRF expression extended the cellular replicative lifespan Interestingly we found that PTRF localized primarily to the nuclei of young and quiescent WI 38 human fibroblasts but translocated to the cytosol and plasma membrane during cellular senescence Furthermore electron microscopic analysis demonstrated an increased number of caveolar structures in senescent and PTRF transfected WI 38 cells Our data suggest that the role of PTRF in cellular senescence is dependent on its targeting to caveolae and its interaction with caveolin 1 which appeared to be regulated by the phosphorylation of PTRF Taken together our findings

    Original URL path: http://www.cell-research.com/arts.asp?id=333 (2016-02-14)
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  • Cell Research
    Abdelilah Wakkach 1 2 5 and Claudine Blin Wakkach 1 2 5 1 CNRS GEPITOS UMR 6235 Faculté de Médecine 06100 Nice France 2 Université de Nice Sophia Antipolis 06000 Nice France 3 Centre d Immunologie de Marseille Luminy INSERM CNRS Parc Scientifique de Luminy 13288 Marseille cedex 09 France 4 Université de la M閐iterranée Parc Scientifique de Luminy 13288 Marseille cedex 09 France 5 INSERM UMR 576 H魀ital de l Archet 06202 Nice France Correspondence Claudine Blin Wakkach Tel 00 33 492 157 702 E mail blin unice fr B cell development is dependent on the interactions between B cell precursors and bone marrow stromal cells but the role of osteoclasts OCLs in this process remains unknown B lymphocytopenia is a characteristic of osteopetrosis suggesting a modulation of B lymphopoiesis by OCL activity To address this question we first rescued OCL function in osteopetrotic oc oc mice by dendritic cell transfer leading to a restoration of both bone phenotype and B cell development To further explore the link between OCL activity and B lymphopoiesis we induced osteopetrosis in normal mice by injections of zoledronic acid ZA an inhibitor of bone resorption B cell number decreased specifically in the bone marrow of ZA treated mice ZA did not directly affect B cell differentiation proliferation and apoptosis but induced a decrease in the expression of CXCL12 and IL 7 by stromal cells associated with reduced osteoblastic engagement Equivalent low osteoblastic engagement in oc oc mice confirmed that it resulted from the reduced OCL activity rather than from a direct effect of ZA on osteoblasts These dramatic alterations of the bone microenvironment were disadvantageous for B lymphopoiesis leading to retention of B cell progenitors outside of their bone marrow niches in the ZA induced osteopetrotic model Altogether our data revealed that OCLs

    Original URL path: http://www.cell-research.com/arts.asp?id=334 (2016-02-14)
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  • Cell Research
    Benoît Lac 1 Institut für Biologie und Biotechnologie der Pflanzen Universit鋞 M黱ster 48149 M黱ster Germany 2 Biochimie et Physiologie Mol閏ulaire des Plantes UMR 5004 CNRS INRA SupAgro UM2 Campus INRA SupAgro Place Viala F34060 Montpellier Cedex 1 France 3 Institut für Biochemie und Biologie Universit鋞 Potsdam Karl Liebkencht Str 24 25 14476 Potsdam Golm Germany Correspondence Jean Baptiste Thibaud Jörg Kudla Tel 33 499 612609 49 251 8324813 E mail thibaud supagro inra fr jkudla uni muenster de Potassium K channel function is fundamental to many physiological processes However components and mechanisms regulating the activity of plant K channels remain poorly understood Here we show that the calcium Ca 2 sensor CBL4 together with the interacting protein kinase CIPK6 modulates the activity and plasma membrane PM targeting of the K channel AKT2 from Arabidopsis thaliana by mediating translocation of AKT2 to the PM in plant cells and enhancing AKT2 activity in oocytes Accordingly akt2 cbl4 and cipk6 mutants share similar developmental and delayed flowering phenotypes Moreover the isolated regulatory C terminal domain of CIPK6 is sufficient for mediating CBL4 and Ca 2 dependent channel translocation from the endoplasmic reticulum membrane to the PM by a novel targeting pathway that is

    Original URL path: http://www.cell-research.com/arts.asp?id=335 (2016-02-14)
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  • Cell Research
    of Plant Genomics Institute of Microbiology Chinese Academy of Sciences No 3 Yard 1 West Beichen Road Chaoyang District Beijing 100101 China 2 National Plant Gene Research Center Beijing 100101 China 3 Graduate School of the Chinese Academy of Sciences Beijing 100049 China 4 Current address Department of Internal Medicine Yale School of Medicine New Haven CT 06510 USA 5 Current address Temasek Life Sciences Laboratory 1 Research Link The National University of Singapore Singapore 117604 Singapore Correspondence Yantao Jia Rongxiang Fang Tel 86 10 64861838 86 10 64858245 E mail jiayt im ac cn fangrx im ac cn We previously reported that XccR a LuxR type regulator of Xanthomonas campestris pv campestris Xcc activates the downstream proline iminopeptidase virulence gene pip in response to certain host plant factor s In this report we further show that the expression of the xccR gene was repressed in the culture medium by an NtrC type response regulator which we named XerR XccR expression related repressor and that this repression was relieved when the bacteria were grown in planta Such a regulatory mechanism is reinforced by the observations that XerR directly bound to the xccR promoter in vitro and that mutations at the phosphorylation related residues of XerR resulted in the loss of its repressor function Furthermore the expression level of xccR increased even in XerR overexpressing Xcc cells when they were vacuum infiltrated into cabbage plants We also preliminarily characterized the host factor s involved in the above mentioned interactions between Xcc and the host plant showing that a plant material s with molecular weight s less than 1 kDa abolished the binding of XerR to the xccR promoter while the same material enhanced the binding of XccR to the luxXc box in the pip promoter Taken together our results implicate XerR

    Original URL path: http://www.cell-research.com/arts.asp?id=336 (2016-02-14)
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  • Cell Research
    Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 7 7 2011 1143 1147 The heterogeneity and dynamic equilibrium of rat embryonic stem cells Yan Shen 1 Cheng Shi 2 Wei Wei 1 3 Weidong Yu 4 Wenlin Li 5 Yang Yang 1 3 Jun Xu 1 Wenqin Ying 6 Xin Sui 1 3 Lingling Fang 6 Weiwei Li 1 Department of Cell Biology and Genetics College of Life Sciences Peking University Beijing 100871 China 2 Reproductive Medical Center Peking University People s Hospital Peking University Beijing 100044 China 3 Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Shenzhen Graduate School of Peking University Shenzhen 518055 China 4 Institute of Clinical Molecular Biology Peking University People s Hospital Peking University Beijing 100044 China 5 Department of Chemistry and the Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA 6 Beijing Vital River Laboratory Animal Inc Beijing 100012 China Correspondence Huan Shen Yan Shi Hongkui Deng Tel 86 10 88324439 86 755 26033257 86 10 6275 6954 E mail rmivf sina com shiyan szpku edu cn hongkui deng pku edu cn Cell Research 2011 21 1143

    Original URL path: http://www.cell-research.com/arts.asp?id=337 (2016-02-14)
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  • Cell Research
    Kou 2 Zhenyu Ju 3 4 Guoguang Zheng 1 4 Jing Xu 1 4 1 State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing Road Tianjin 300020 China 2 National Institute of Biological Sciences 7 Science Park Road Zhongguancun Life Science Park Beijing 102206 China 3 Max Planck Partner Group on Stem Cell Aging Institute

    Original URL path: http://www.cell-research.com/arts.asp?id=338 (2016-02-14)
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  • Cell Research
    Publication Current Issue Top 10 VOLUME 21 ISSUE 7 7 2011 1152 1154 Maximizing target protein ablation by integration of RNAi and protein knockout Jeffrey Hannah and Pengbo Zhou Department of Pathology and Laboratory Medicine Weill Cornell Medical College and Weill Cornell Graduate School of Medical Sciences 1300 York Avenue New York NY 10065 USA Correspondence Pengbo Zhou Tel 212 746 6415 E mail pez2001 med cornell edu Cell Research

    Original URL path: http://www.cell-research.com/arts.asp?id=339 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=23 (2016-02-14)




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