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  • Cell Research
    Road Shanghai 200438 China 2 State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China Correspondence Hong yang Wang Tel 86 21 2507 0856 E mail hywangk vip sina com p28 GANK also known as PSMD10 or gankyrin is a novel oncoprotein that is highly expressed in hepatocellular carcinoma HCC Through its interaction with various proteins p28 GANK mediates the degradation of the tumor suppressor proteins Rb and p53 Although p53 was reported to downregulate β catenin whether p28 GANK is involved in the regulation of β catenin remains uncertain Here we report that both growth factors and Ras upregulate p28 GANK expression through the activation of the phosphoinositide 3 kinase AKT pathway Upregulation of p28 GANK expression subsequently enhanced the transcription activity of β catenin This effect was observed in p53 deficient cells suggesting a p53 independent mechanism for the p28 GANK mediated activation of β catenin p28 GANK overexpression also reduced E cadherin protein levels leading to increased release of free β catenin into the cytoplasm from the cadherin bound pool Interestingly exogenous expression of p28 GANK resulted in elevated expression of the endogenous protein We also

    Original URL path: http://www.cell-research.com/arts.asp?id=318 (2016-02-14)
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  • Cell Research
    Li 2 Rong Zeng 2 Zhiqi Xiong 3 Chen Zhong 1 and Jianping Ding 1 1 State Key Laboratory of Molecular Biology and Research Center for Structural Biology 320 Yue Yang Road Shanghai 200031 China 2 Key Laboratory of Systems Biology Institute of Biochemistry and Cell Biology 320 Yue Yang Road Shanghai 200031 China 3 State Key Laboratory of Neuroscience Institute of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy

    Original URL path: http://www.cell-research.com/arts.asp?id=319 (2016-02-14)
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  • Cell Research
    1270 Two transposable element insertions are causative mutations for the major domestication gene teosinte branched 1 in modern maize Liangliang Zhou 1 Junya Zhang 1 Jianbing Yan 2 and Rentao Song 1 1 Shanghai Key Laboratory of Bio energy Crops School of Life Sciences Shanghai University 99 Shangda Road Shanghai 200444 China 2 National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Correspondence Rentao Song Tel

    Original URL path: http://www.cell-research.com/arts.asp?id=320 (2016-02-14)
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  • Cell Research
    enterovirus 71 Shiqi Xie 1 Kai Wang 1 Wenjing Yu 1 Wei Lu 1 8 Ke Xu 1 Jianwei Wang 2 Bin Ye 3 Wolfgang Schwarz 4 5 6 Qi Jin 2 and Bing Sun 1 7 1 Key Laboratory of Molecular Virology and Immunology Institut Pasteur of Shanghai Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 225 South Chongqing Road Shanghai 200025 China 2 Institute of Pathogen Biology Chinese Academy of Medical Sciences Beijing 100176 China 3 Department of Medicine Section of Cardiovascular Medicine School of Medicine Room 24 SMI building 1300 University Avenue University of Wisconsin Madison WI 53706 USA 4 Max Planck Guest Laboratory Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 5 Max Planck Institute for Biophysics Max von Laue Strasse 3 60438 Frankfurt M Germany 6 Shanghai Research Center for Acupuncture and Meridians 199 Guo Shoujing Road Shanghai 201203 China 7 Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 320 Yueyang Road Shanghai 200031 China 8 Current address Molecular Development Section Laboratory of Immunology National Institute of Allergy and Infectious Diseases National Institutes of Health

    Original URL path: http://www.cell-research.com/arts.asp?id=321 (2016-02-14)
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  • Cell Research
    through suppressing PDGFRβERK signaling and increase in p27 accumulation and prevents injury induced neointimal hyperplasia Li Hua Dong 1 Jin Kun Wen 1 Sui Bing Miao 1 Zhenhua Jia 2 Hai Juan Hu 1 Rong Hua Sun 1 Yiling Wu 2 and Mei Han 1 1 Department of Biochemistry and Molecular Biology Institute of Basic Medicine Key Laboratory of Neural and Vascular Biology China Ministry of Education No 361 Zhongshan

    Original URL path: http://www.cell-research.com/arts.asp?id=322 (2016-02-14)
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  • Cell Research

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    Original URL path: /artsmore1.asp?id=22 (2016-02-14)


  • Cell Research
    1001 0602 EISSN 1748 7838 2012 impact factor 10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 9 9 2011 1277 1278 Bmi1 puSHHes reprogramming Han Li and Manuel Serrano Tumor Suppression Group Spanish National Cancer Research Centre CNIO 3 Melchor Fernandez Almagro Street Madrid E 28029 Spain Correspondence Han Li E mail hli cnio es FULL TEXT PDF Browse

    Original URL path: http://www.cell-research.com/arts.asp?id=296 (2016-02-14)
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  • Cell Research
    10 526 Thomson Reuters 2013 Free Sample Issue Submission Advanced Online Publication Current Issue Top 10 VOLUME 21 ISSUE 9 9 2011 1279 1282 A reaction to mitochondria in action Mark P Mattson Laboratory of Neurosciences National Institute on Aging Intramural Research Program Baltimore MD 21224 Correspondence Mark P Mattson E mail MattsonM grc nia nih gov Cell Research 2011 21 1279 1282 doi 10 1038 cr 2011 87 published

    Original URL path: http://www.cell-research.com/arts.asp?id=297 (2016-02-14)
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