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  • Cell Research
    VOLUME 21 ISSUE 12 12 2011 1646 1648 A lincRNA switch for embryonic stem cell fate Liuqing Yang 1 Chunru Lin 1 and Michae 1 G Rosenfeld 1 2 1 Howard Hughes Medical Institute 2 Department of Medicine Division of Endocrinology and Metabolism University of California San Diego School of Medicine 9500 Gilman Drive La Jolla CA 92093 0648 USA Correspondence Liuqing Yang Michael G Rosenfeld E mail liy001 ucsd

    Original URL path: http://www.cell-research.com/arts.asp?id=250 (2016-02-14)
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  • Cell Research
    Active DNA demethylation by oxidation and repair Zhizhong Gong 1 and Jian Kang Zhu 2 3 1 State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China 2 Center for Plant Stress Genomics and Technology King Abdullah University of Science and Technology Thuwal 23955 6900 Kingdom of Saudi Arabia 3 Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47907

    Original URL path: http://www.cell-research.com/arts.asp?id=251 (2016-02-14)
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  • Cell Research
    Top 10 VOLUME 21 ISSUE 12 12 2011 1652 1654 Hierarchy and plasticity in the crypt back to the drawing board Catherine Legraverend 1 2 3 and Philippe Jay 1 2 3 1 CNRS UMR 5203 Institut de Génomique Fonctionnelle Montpellier France 2 INSERM U661 Montpellier France 3 Universités de Montpellier 1 2 France Correspondence Catherine Legraverend Philippe Jay E mail catherine legraverend igf cnrs fr philippe jay igf cnrs

    Original URL path: http://www.cell-research.com/arts.asp?id=252 (2016-02-14)
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  • Cell Research
    VOLUME 21 ISSUE 12 12 2011 1655 1661 Novel functions of endocytic player clathrin in mitosis Wenxiang Fu Qing Jiang and Chuanmao Zhang The MOE Key Laboratory of Cell Proliferation and Differentiation and the State Key Laboratory of Bio membrane and Membrane Biotechnology College of Life Sciences Peking University Beijing 100871 China Correspondence Chuanmao Zhang Tel 86 10 62757173 E mail zhangcm pku edu cn Clathrin has been widely recognized as a pivotal player in endocytosis in which several adaptors and accessory proteins are involved Recent studies suggested that clathrin is also essential for cell division Here this review mainly focuses on the clathrin dependent mechanisms involved in spindle assembly and chromosome alignment In mitosis clathrin forms a complex with phosphorylated TACC3 to ensure spindle stability and proper chromosome alignment The clathrin regulated mechanism in mitosis requires the crosstalk among clathrin spindle assembly factors SAFs Ran GTP and mitotic kinases Meanwhile a coordinated mechanism is required for role transitions of clathrin during endocytosis and mitosis Taken together the findings of the multiple functions of clathrin besides endocytosis have expanded our understanding of the basic cellular activities Cell Research 2011 21 1655 1661 doi 10 1038 cr 2011 106 published online

    Original URL path: http://www.cell-research.com/arts.asp?id=253 (2016-02-14)
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  • Cell Research
    10 VOLUME 21 ISSUE 12 12 2011 1662 1669 Elimination of paternal mitochondria through the lysosomal degradation pathway in C elegans Qinghua Zhou Haimin Li and Ding Xue Qinghua Zhou Haimin Li and Ding Xue Correspondence Ding Xue E mail ding xue colorado edu In mammals the inheritance of mitochondrion and its DNA mtDNA is strictly maternal despite the fact that a sperm can inject up to 100 functional mitochondria into the oocyte during fertilization The mechanisms responsible for the elimination of the paternal mitochondria remain largely unknown We report here that this paternal mitochondrial elimination process is conserved in Caenorhabditis elegans and that the lysosomal pathway actively participates in this process Molecular and cell biological analyses indicate that in wild type animals paternal mitochondria and mtDNA are destroyed within two hours after fertilization In animals with compromised lysosomes paternal mitochondria persist until late embryonic stages Therefore the lysosomal pathway plays an important role in degrading paternal mitochondria introduced into the oocyte during fertilization Our study indicates that C elegans is an excellent animal model for understanding and dissecting this conserved biological process critical for animal development and reproduction Cell Research 2011 21 1662 1669 doi 10 1038 cr 2011

    Original URL path: http://www.cell-research.com/arts.asp?id=254 (2016-02-14)
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  • Cell Research
    2 Department of Biochemistry and Biophysics Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA 3 Department of Chemistry and Institute for Biophysical Dynamics the University of Chicago Chicago IL 60637 USA Correspondence Yi Zhang Tel 1 919 843 8225 E mail yi zhang med unc edu One of the recent advances in the epigenetic field is the demonstration that the Tet family of proteins are capable of catalyzing conversion of 5 methylcytosine 5mC of DNA to 5 hydroxymethylcytosine 5hmC Interestingly recent studies have shown that 5hmC can be further oxidized by Tet proteins to generate 5 formylcytosine 5fC and 5 carboxylcytosine 5caC which can be removed by thymine DNA glycosylase TDG To determine whether Tet catalyzed conversion of 5mC to 5fC and 5caC occurs in vivo in zygotes we generated antibodies specific for 5fC and 5caC By immunostaining we demonstrate that loss of 5mC in the paternal pronucleus is concurrent with the appearance of 5fC and 5caC similar to that of 5hmC Importantly instead of being quickly removed through an enzyme catalyzed process both 5fC and 5caC exhibit replication dependent dilution during mouse preimplantation development These results not only demonstrate the conversion

    Original URL path: http://www.cell-research.com/arts.asp?id=255 (2016-02-14)
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  • Cell Research
    86 10 64807970 E mail xinhua lin ioz ac cn xinhua lin cchmc org Drosophila Wingless Wg acts as a morphogen during development Wg secretion is controlled by a seven pass transmembrane cargo Wntless Wls We have recently identified retromer as a key regulator involved in Wls trafficking As sorting nexin SNX molecules are essential components of the retromer complex we hypothesized that specific SNX s is required for retromer mediated Wnt secretion Here we generated Drosophila mutants for all of the eight snx members and identified Drosophila SNX3 DSNX3 as an essential molecule required for Wg secretion We show that Wg secretion and its signaling activity are defective in Dsnx3 mutant clones in wing discs Wg levels in the culture medium of Dsnx3 depleted S2 cells are also markedly reduced Importantly Wls levels are strikingly reduced in Dsnx3 mutant cells and overexpression of Wls can rescue the Wg secretion defect observed in Dsnx3 mutant cells Moreover DSNX3 can interact with the retromer component Vps35 and co localize with Vps35 in early endosomes These data indicate that DSNX3 regulates Wg secretion via retromer dependent Wls recycling In contrast we found that Wg secretion is not defective in cells mutant for

    Original URL path: http://www.cell-research.com/arts.asp?id=256 (2016-02-14)
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  • Cell Research
    3 Cuijun Zhang 1 Wei Chen 2 Jinxing Zhou 1 Suwei Zhang 1 Qing Chen 1 Xin Deng 2 4 Xin Jian He 1 and Jian Kang Zhu 2 1 National Institute of Biological Sciences Beijing 102206 China 2 Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47907 USA 3 School of Agriculture and Biology Shanghai Jiao Tong University Shanghai 200240 China 4 Institute of Botany Chinese Academy of Sciences Beijing 100093 China Correspondence Xin Jian He Tel 86 10 80707712 E mail hexinjian nibs ac cn RNA directed DNA methylation RdDM is an important de novo DNA methylation pathway in plants RdDM mediates the transcriptional silencing of many endogenous genomic loci most of which are transposon related A forward genetics screen identified DTF1 DNA binding transcription factor 1 as a new component for RdDM in Arabidopsis Loss of function mutations in DTF1 release the transcriptional silencing of RdDM target loci and reduce the accumulation of 24 nt small interfering RNAs siRNAs from some of the targets Interestingly in the dtf1 mutant plants the release of transcriptional gene silencing at solo LTR is accompanied by decreased siRNA accumulation but not by reduced DNA methylation These results suggest

    Original URL path: http://www.cell-research.com/arts.asp?id=257 (2016-02-14)
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