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  • Cybergenetics :: An Expert System for Scoring DNA Database Profiles
    such databases is quite laborious After generating STR profiles in the lab people expend even greater effort visually reviewing the data before it enters the database All artifacts must be detected and no error can be tolerated With millions of forensic samples to be analyzed this bottleneck has become a formidable task We have developed software analysis methods that can automate this data review and potentially eliminate 90 of the work Our fully automated TrueAllele 174 system inputs raw fluorescent DNA sequencer gel or capillary files processes the gel image separating colors tracking and sizing lanes and analyzes the STR experiments quantitating and sizing peaks comparing with ladder peaks calling alleles For each allele call TrueAllele assigns a quality score and applies artifact detection rules These quality checks enable a user to focus on just the 10 of suspect data thereby eliminating most of the review effort TrueAllele models every step of the STR data generation process By computing hundreds of variables for each genotype the system can compare the observed data against expected behavior Large deviations between expected and observed enable the software to flag potentially problematic data for human review TrueAllele automatically extracts the information it needs from the raw data e g ABI 377 collection files After automated image processing the software provides a user quality assurance review for assessing data runs lane tracking gel quality control lanes etc Automated data processing continues with peak quantitation allele designation and quality scoring In the allele based quality assurance review the user focuses on those designations which TrueAllele has flagged as having specific problems After reviewing and possibly editing this small subset of data TrueAllele then generates files for submission to the DNA database e g CODIS TrueAllele operates independently of DNA sequencer manufacturer or technology and runs on

    Original URL path: http://www.cybgen.com/information/publication/2000/ISHI/Perlin-An-expert-system-for-scoring-DNA-database-profiles/page.shtml (2016-02-12)
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  • Cybergenetics :: Kern County resolves the DNA mixture crisis
    can greatly complicate data interpretation since DNA analysts must account for data patterns that include many peaks of varying height There are a vast number of weighted genotype combinations with multiple ways to explain the data This complexity makes it hard for analysts to readily differentiate probable from improbable genotypes The difficulty in manually interpreting complex DNA mixtures has consequences Hundreds of thousands of evidentiary items have been collected and

    Original URL path: http://www.cybgen.com/information/publication/2014/FM/Perlin-Miller-Kern-County-resolves-the-DNA-mixture-crisis/page.shtml (2016-02-12)
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  • Cybergenetics :: The continuing legal evolution of forensic DNA
    DNA can serve as a key piece of evidence particularly given the CSI effect the media has attached to DNA However as with all scientific evidence there are strengths and limitations of forensic DNA tests which are important knowledge points for lawyers as they prepare their cases Furthermore as with the law science continues to evolve which makes it critical for lawyers to be aware of scientific advancements that may

    Original URL path: http://www.cybgen.com/information/publication/2013/PL/Williams-Panella-The-continuing-legal-evolution-of-forensic-DNA/page.shtml (2016-02-12)
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  • Cybergenetics :: Easy reporting of hard DNA: computer comfort in the courtroom
    may lack rigor CPI and other threshold based methods modify data ignore variables and discard information in order to enable approximate human solution The alternative may be reporting nothing at all e g inconclusive But these simplifications are not based on a tested statistical model or on solid mathematics Much important DNA evidence often crucial to a case or public safety has been discarded by overly simplistic interpretation Analysts often

    Original URL path: http://www.cybgen.com/information/publication/2012/FM/Perlin-Easy-reporting-of-hard-DNA-computer-comfort-in-the-courtroom/page.shtml (2016-02-12)
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  • Cybergenetics :: Computer DNA evidence interpretation in the Real IRA Massereene terrorist attack
    was ruptured on the night of March 7 2009 when two hooded gunmen emerged from a car outside the Massereene Barracks with assault rifles In the first attack on British soldiers in over ten years the assailants fired more than 60 rounds at unarmed soldiers and civilians killing Sappers Mark Quinsey and Patrick Azimkar who were collecting a Domino s pizza delivery The Real IRA paramilitary organization claimed responsibility for the attack The action was universally denounced by all parties in Northern Ireland and actually strengthened the peace process The abandoned getaway car was burned to destroy personally identifying evidence but trace amounts of touch DNA were left on a few items This low level and mixed DNA evidence associated two Republican dissidents Colin Duffy and Brian Shivers with the vehicle or its torching Their nonjury Belfast trial began in November 2011 before Judge Anthony Hart and lasted two months presenting considerable forensic evidence witnesses do not testify in such cases Pittsburgh based Cybergenetics TrueAllele 174 computer system provided DNA match statistics for several of the getaway car evidence items which human review could not After three days of expert testimony and cross examination Judge Hart admitted the computer interpretation

    Original URL path: http://www.cybgen.com/information/publication/2012/ETM/Perlin-Galloway-Computer-DNA-evidence-interpretation-in-the-Real-IRA-Massereene-terrorist-attack/page.shtml (2016-02-12)
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  • Cybergenetics :: Forensic science in the information age
    Magazine 9 2 17 21 2012 Downloads Formatted magazine article requires Flash Printer friendly with references Abstract An information age demands information We expect a Google search to return thorough objective and informative results using the best available probability computer model methods Our human minds ask questions and we rely on the computer to calculate the best answers Whether cracking a code diagnosing disease piloting a plane or working on Wall Street our lives and livelihoods depend on computer thought Apprehending criminals through forensic intelligence is no exception we want the most informative computers working 24 7 to provide protection DNA laboratories are now bringing computers on board to extend their forensic examiners analytic capability A scientist can organize evidence and frame forensic questions robots and computers can then automate the mechanics A forensic scientist can incorporate informative DNA match statistics from complex mixture calculations into their case reports and provide testimony in court Experts excel at human activities while computers are better calculators Even before their crime labs deploy computer interpretation police investigators and trial attorneys can rely on the private sector to deliver computer processing case reports and expert witness services The NAS report identified ways to strengthen

    Original URL path: http://www.cybgen.com/information/publication/2012/FM/Perlin-Forensic-science-in-the-information-age/page.shtml (2016-02-12)
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  • Cybergenetics :: How it works: DNA information library service
    requires Flash Abstract DNA information is an important way to identify criminals In today s forensic DNA model biological crime scene evidence is processed by a DNA laboratory producer which both generates and interprets electronic data The lab then notifies DNA information consumers such as police prosecutors and defense With the advent of lab automation though robots are generating ever greater quantities of more challenging DNA data Painstaking human review of difficult data is slow and expensive and loses considerable identification information 1 This information loss discarding informative data as inconclusive or reducing match strength a million fold diminishes DNA evidence Computer based probabilistic genotyping 2 Sect 3 2 2 can eliminate the interpretation bottleneck providing a thorough accurate and objective statistical review of the DNA evidence 1 Cybergenetics has been pioneering an on demand approach to DNA interpretation that serves the criminal justice community In this new DNA processing paradigm a public crime lab identifies challenging data and forwards it electronically to their Cybergenetics partner for computer processing Within days the company sends a TrueAllele 174 match report to the prosecutor or other DNA information consumer The laboratory is thus relieved of the burden of interpreting challenging DNA data

    Original URL path: http://www.cybgen.com/information/publication/2012/FM/Perlin-How-it-works-DNA-information-library-service/page.shtml (2016-02-12)
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  • Cybergenetics :: The Blairsville slaying and the dawn of DNA computing
    Death Needs Answers The Cold Blooded Murder of Dr John Yelenic A Niapas Ed New Kensington PA Grelin Press 2013 Downloads The chapter manuscript can be downloaded here Abstract Commonwealth v Foley was a landmark case in the history of DNA evidence It was the first time that an advanced statistical computing method for interpreting DNA mixtures was ever used as evidence for a criminal case admitted into evidence after

    Original URL path: http://www.cybgen.com/information/publication/2013/DNA/Perlin-The-Blairsville-slaying-and-the-dawn-of-DNA-computing/page.shtml (2016-02-12)
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