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  • Cybergenetics :: New Study Questions the Validity of Forensic DNA Match Statistic
    statistics has been questioned The Combined Probability of Inclusion CPI is a popular match statistic for DNA mixtures For 15 years crime laboratories have generated CPI statistics on hundreds of thousands of mixtures However a new study shows that CPI behaves more like a random number generator than like a reliable measure of human identification The research article Inclusion probability for DNA mixtures is a subjective one sided match statistic unrelated to identification information was published last week in the Journal of Pathology Informatics The paper explains why CPI always gives the same one in a million answer instead of providing accurate match information How DNA mixtures are interpreted affects criminal justice and public safety says author Dr Mark Perlin of Cybergenetics The inclusion method compares a mixture with a suspect relying on CPI for statistical support But if CPI does not accurately convey identification information its patina of science lends no meaningful support The FBI s free PopStats software includes a CPI calculator However a 2005 NIST study showed 69 crime laboratories reporting a wide range of inaccurate statistics from ten thousand to hundred trillion or just inconclusive on the same mixture sample The FBI has never developmentally validated

    Original URL path: http://www.cybgen.com/information/press-release/2015/New-Study-Questions-the-Validity-of-Forensic-DNA-Match-Statistic/page.shtml (2016-02-12)
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  • Cybergenetics :: New York Court Admits TrueAllele After Frye Challenge
    While crime laboratories can generate informative data from such DNA older mixture interpretation methods CPI CLR often fail to produce a match statistic So tens of thousands of DNA items have been processed but never used as criminal evidence Judge Coccoma found that computerized probabilistic approaches and likelihood ratio principles used by Cybergenetics TrueAllele Casework are superior to current methods Moreover Cybergenetics TrueAllele Casework has been demonstrated to be one of if not the most advanced method of interpreting DNA profiles from mixed and low template DNA It has been proved to be more accurate than CPI and CLR preserves more of the identification information eliminates examiner bias produces a match value which human review may not and permits standardization of mixture reporting whereas human review approaches can lead to very different match statistics on the same DNA data The New York State DNA Subcommittee of the Commission on Forensic Science unanimously approved TrueAllele in May of 2011 for use by the New York State Police NYSP for their forensic casework The full Commission ratified that approval in July of 2011 The NYSP have been using TrueAllele Databank for a decade to eliminate convicted offender backlogs and upload profiles to

    Original URL path: http://www.cybgen.com/information/press-release/2015/New-York-Court-Admits-TrueAllele-After-Frye-Challenge/page.shtml (2016-02-12)
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  • Cybergenetics :: United States Patent Awarded for Computerized DNA Mixture Analysis
    analysis patent EP1229135 to Dr Perlin These seminal inventions have a 2001 priority date Cybergenetics is an American bioinformation company specializing in the analysis of complex DNA evidence Most DNA evidence is a mixture of two or more people Conventional forensic analysis over simplifies mixture data and may understate a DNA match statistic or reach no conclusion Tens of thousands of crimes have informative DNA evidence that is never used for criminal justice Many rapes and homicides with excellent DNA are not solved because of inadequate data analysis Cybergenetics TrueAllele Casework technology solves the mixture problem through sophisticated computing that uses all the DNA data Developed and refined over ten years and extensively validated for another five years TrueAllele has been used in over two hundred criminal cases across twenty three states TrueAllele s reliability has been established in many scientific studies and in court We are pleased that the USPTO has once again recognized our pioneering forensic science innovations in DNA mixture analysis said Cybergenetics President Dr Ria David The patented and proven TrueAllele technology provides fast and accurate DNA reporting that other methods cannot match helping to secure justice for victims and protect society from crime TrueAlleles separates

    Original URL path: http://www.cybgen.com/information/press-release/2014/United-States-Patent-Awarded-for-Computerized-DNA-Mixture-Analysis/page.shtml (2016-02-12)
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  • Cybergenetics :: TrueAllele DNA Analysis Prevails in Louisiana Daubert Challenge
    November 6th following a Daubert hearing held that same day Cybergenetics TrueAllele software accurately separates DNA mixture evidence into component genotypes to calculate DNA match statistics The Honorable Richard D Anderson ruled that TrueAllele s match statistics met the Daubert admissibility standard for reliable evidence in a homicide case involving a DNA mixture from a handgun We are grateful that the Judge recognized the reliability of TrueAllele technology said East Baton Rouge District Attorney Hillar C Moore III We look forward to the continued use of this probabilistic genotyping to aid the prosecution of cases involving complex and low level DNA mixtures The United States Supreme Court established the Daubert standard in 1993 to help keep junk science out of the courtroom Daubert has four prongs testability peer review error rate and general acceptance by the relevant scientific community Assistant District Attorney Dana Cummings showed how TrueAllele has been extensively tested in seven peer reviewed scientific publications and used in twenty three states The computer system has overcome admissibility challenges in California Louisiana Ohio Pennsylvania and Virginia TrueAllele separates DNA mixtures and provides informative match statistics said Dr Ria David Cybergenetics President Our scientific advances promote justice in criminal cases

    Original URL path: http://www.cybgen.com/information/press-release/2014/TrueAllele-DNA-Analysis-Prevails-in-Louisiana-Daubert-Challenge/page.shtml (2016-02-12)
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  • Cybergenetics :: TrueAllele Casework Ruled Admissible in Ohio Daubert Challenge
    a guilty plea shortly after the Cleveland ruling Cybergenetics TrueAllele is a computer system that uses sophisticated mathematics to accurately determine DNA match statistics Forensic DNA data can pose interpretation challenges particularly with mixtures of two or more people Crime labs may under report highly informative mixtures as inconclusive discarding valuable evidence TrueAllele preserves this identification information to aid criminal investigations convictions and exonerations DNA evidence is invaluable to the criminal justice system and so every advancement in analyzing it advances the cause of justice said Cuyahoga County Prosecutor Timothy J McGinty Judge Clancy s ruling to accept Dr Perlin as an expert witness and to find TrueAllele s DNA mixture analysis admissible is an important step forward that will improve the scientific fact finding abilities of all parties in the criminal justice system The winning Cuyahoga County Prosecutors Office team included Assistant Prosecuting Attorneys Katherine Mullin Margaret Troia and Scott Zarzycki with assistance from Kristen Hatcher Prosecution expert witnesses were Dr Mark Perlin of Cybergenetics and forensic scientist Jay Caponera from the New York State Police Professors Ranajit Chakraborty and Dan Krane testified for the defense TrueAllele makes a real difference every day in protecting the public from rapists

    Original URL path: http://www.cybgen.com/information/press-release/2014/TrueAllele-Casework-Ruled-Admissible-in-Ohio-Daubert-Challenge/page.shtml (2016-02-12)
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  • Cybergenetics :: TrueAllele Used in New York Court for the First Time
    that had eluded manual forensic analysis Serial rapist Casey Wilson left his DNA on a glove along with DNA from victims The NYS police crime lab developed a DNA profile from the glove However the mixture data was too complex for them to make comparisons A Cybergenetics TrueAllele computer in hours separated the complex data into three genotypes TrueAllele compared these genotypes with Wilson and the victim to calculate match statistics Cybergenetics scientist Dr Mark Perlin testified at the Elmira trial that a match between the glove and Wilson was 31 million times more probable than coincidence Chemung County District Attorney Weeden Wetmore stated the DNA evidence connecting the defendant to the crime was significant In under an hour the jury convicted Wilson of multiple counts of first degree rape and sexual assault Wilson faces up to 40 years in prison Tens of thousands of DNA mixture items are unreported by crime labs DNA evidence that TrueAllele can successfully resolve Taxpayers expect this DNA to help solve rapes and homicides but the data are not used TrueAllele helps convert such discarded data into powerful information that can identify criminals exclude innocent suspects and prevent further victimization TrueAllele is the most

    Original URL path: http://www.cybgen.com/information/press-release/2014/TrueAllele-Used-in-New-York-Court-for-the-First-Time/page.shtml (2016-02-12)
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  • Cybergenetics :: TrueAllele Helps Prosecutors Secure Two Guilty Pleas This Week
    orphaned DNA evidence TrueAllele s sophisticated computing thoroughly assesses a lab s DNA data and produces an objective match statistic Scientifically validated TrueAllele analysis has helped in hundreds of criminal cases for both prosecution and defense A New York father was thought to have raped his daughter every week from age seven for seven years This week he pleaded guilty to third degree rape in a Westchester courthouse The key physical evidence was TrueAllele results on five semen stains from his bedroom blanket The crime lab couldn t statistically assess the DNA mixtures because the father and daughter were related TrueAllele analysis of the data resolved the mixtures Computer separation put the daughter s DNA on the blanket with a match statistic of seventy quadrillion A District Attorney protects the public said Dr Mark Perlin Cybergenetics Chief Scientific Officer Using Cybergenetics TrueAllele the DA could achieve a just outcome without subjecting a young victim to further torment in the courtroom In York County this week a Pennsylvania man pleaded to third degree murder in the stabbing death of a 42 year old neighbor in her home The crime laboratory could not fully interpret the DNA mixture but TrueAllele s match

    Original URL path: http://www.cybgen.com/information/press-release/2014/TrueAllele-Helps-Prosecutors-Secure-Two-Guilty-Pleas-This-Week/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics TrueAllele Validated on Virginia DNA Mixture Cases
    reported criminal cases This fifth TrueAllele validation article was viewed a thousand times in one month at the open access PLoS ONE journal website When federal forensic DNA interpretation guidelines changed four years ago higher stochastic thresholds rendered previously reported DNA evidence unusable Rather than withdraw DNA from criminal justice the Virginia Department of Forensic Science DFS had Cybergenetics reevaluate the data using TrueAllele Cybergenetics issued reports in 72 cases on 92 DNA mixtures most containing 3 or 4 contributors The validation study compares the reported computer match statistics with manual threshold methods on the same data TrueAllele gave an average match statistic of 113 billion on the cases Manual stochastic threshold analysis averaged 140 a billion fold reduction The computer could make DNA comparisons that were impossible or impractical using manual methods There is no scientific reason to abandon informative DNA mixture evidence says Dr Mark Perlin lead author and senior scientist at Cybergenetics The study showed that TrueAllele computer interpretation of DNA mixture evidence is sensitive specific precise accurate and more informative than manual interpretation alternatives Moreover TrueAllele can determine DNA match statistics when threshold based methods cannot TrueAllele is a useful forensic tool says DFS scientist and

    Original URL path: http://www.cybgen.com/information/press-release/2014/Cybergenetics-TrueAllele-Validated-on-Virginia-DNA-Mixture-Cases/page.shtml (2016-02-12)
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