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  • Cybergenetics :: New York State Police to Deploy FBI Approved TrueAllele® Expert System for DNA Review
    year Cybergenetics TrueAllele computer system which automatically interprets DNA data without error is in the first group to ever receive such FBI approval Four years ago the NYSP Forensic Identification Center in Albany NY was the first to submit an expert system validation study to NDIS The NYSP later published their groundbreaking scientific validation in the Journal of Forensic Sciences where it became the foundation for the FBI s expert system validation standards Writing in 2002 Dr Barry Duceman Director of Biological Sciences at the NYSP FIC predicted that the time people spent sifting through DNA items would be reduced by an automated genotyping system He observed that software solutions are emerging that can be integrated into an automated approach He also noted that the goal of automation is not simply productivity but an attendant increase in data reproducibility and reliability The NYSP FIC processes both casework DNA from crime scenes and databank DNA from convicted offenders When a criminal leaves biological material at a crime scene this unknown DNA can be compared against the DNA databank profiles in order to identify the perpetrator Cybergenetics TrueAllele Databank system accelerates the construction of DNA databanks by eliminating virtually all of the human steps currently involved in the painstaking manual review of DNA data We are pleased to see the New York State Police finally able to deploy our TrueAllele expert system says Dr Mark Perlin CEO of Cybergenetics Careful human review of one plate of DNA databank samples takes five hours of examination and cross checking from data generation to NDIS upload Our workflow studies show how a TrueAllele computer can reduce the total human involvement to just five minutes And as multiple scientific validation studies have demonstrated Cybergenetics automated TrueAllele computer process is more accurate than current manual approaches Conventional

    Original URL path: http://www.cybgen.com/information/press-release/2006/New-York-State-Police-to-Deploy-FBI-Approved-TrueAllele-Expert-System-for-DNA-Review/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics Awarded Justice Contract for DNA Analysis
    cost error and tedium of manually reviewing forensic data High quality review of DNA data is essential for convicting the guilty and exonerating the innocent TrueAllele uniquely provides the high quality cost saving speedup that will take criminals off our streets Collaborating on this project are two leading DNA database laboratories Florida and Virginia These state labs use different sequencer technologies gel capillary DNA panels and computer platforms to process their DNA samples Cybergenetics will assess TrueAllele s cross platform success on their diverse data sets by automatically reanalyzing 30 000 samples The Florida Department of Law Enforcement s Convicted Offender DNA Database has been introducing automation and state of the art equipment to the rapid analysis of offender samples since 1996 notes David Coffmann supervisor of the Florida database Our goal has always been to throw technology towards a problem rather than personnel The missing piece of the puzzle has been the data review process It is very time consuming and with the large amount of DNA results being produced by our automated techniques it has proven difficult to analyze all the data we are producing This project if successful will solve this problem We are excited to be a part of this collaboration Dr Paul Ferrara director of the Virginia database observes As the demands for more timely and comprehensive testing of crime scene evidence and databank samples increase the forensic science community will need to increase capacities and throughput correspondingly without sacrificing quality Novel approaches such as TrueAllele to expediting the time consuming post analysis interpretation phase inherent in forensic work especially with mixtures offer significant potential to assist in increasing case throughput The British Forensic Science Service FSS has built the UK national DNA database which currently includes over 800 000 convicted offender profiles TrueAllele was

    Original URL path: http://www.cybgen.com/information/press-release/2000/Cybergenetics-Awarded-Justice-Contract-for-DNA-Analysis/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics Awarded Lane Tracking Patent
    based DNA fragment data Automated gel tracking saves considerable time and improves data quality The recently issued US 6 054 268 broadly protects automated lane tracking functionality and includes claims on genes discovered via such automation Translating DNA signals into useful information is currently a labor intensive task that accounts for over half the cost of generating STR based DNA data Cybergenetics TrueAllele software overcomes this exhausting data review bottleneck by providing an automated expert system that replicates and replaces current human expertise Cybergenetics powerful technology accelerates genetic discovery and forensic DNA databasing while reducing costs significantly TrueAllele automates DNA data review in many ways says Dr Perlin With good data Cybergenetics expert system largely eliminates human involvement With problematic data TrueAllele identifies the problem and provides feedback to help improve data quality Cybergenetics four TrueAllele patents US 5 541 067 5 580 728 5 876 933 and 6 054 268 are described at www cybgen com see technology These patents have broad and deep claims covering every aspect of automated STR analysis including quality assurance e g data error genotype accuracy and quality measures and removing PCR stutter and other data artifacts The patents reach through to genes and

    Original URL path: http://www.cybgen.com/information/press-release/2000/Cybergenetics-Awarded-Lane-Tracking-Patent/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics Quality-Based Genetic Analysis Automation Technology
    review of every genotype causing significant delay error expense and risk in high throughput genotyping says Dr Mark Perlin CEO of Cybergenetics Our computer based TrueAllele technology performs 90 of this data review and focuses the human review on just the 5 10 of problematic calls This automation greatly accelerates genetic discovery Cybergenetics third TrueAllele patent issued last March US patent No 5 876 933 has broad and deep claims that cover automated STR analysis including quality issues such as quantitating error and genotyping accuracy This patent drawing on six years of unchallenged technological leadership also covers high throughput genotyping genetic discovery and diagnosis and forensic applications deCODE Genetics and Cybergenetics coauthored the article Using quality measures to facilitate allele calling in high throughput genotyping which appeared in Genome Research in October Says Dr Jeff Gulcher Vice President of Research and Development for deCODE Genetics It has allowed us to scale up to become the largest microsatellite genotyping facility in the world generating almost 2 million genotypes per month TrueAllele has led to a labor savings in editing of at least 80 freeing up our scientists to do more creative things with their time TrueAllele automatically tracks and scores STR

    Original URL path: http://www.cybgen.com/information/press-release/2000/Cybergenetics-Quality-Based-Genetic-Analysis-Automation-Technology/page.shtml (2016-02-12)
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  • Cybergenetics :: deCODE genetics Renews License for Cybergenetics Automated Genotyping Technology
    this data review and focuses the human review on just the 5 10 of problematic calls This automation greatly accelerates genetic discovery We are delighted to renew the license with Cybergenetics for their TrueAllele software package says Dr Jeff Gulcher Vice President of Research and Development for deCODE genetics It has allowed us to scale up to become the largest microsatellite genotyping facility in the world generating almost 2 million genotypes per month TrueAllele has led to a labor savings in editing of at least 80 freeing up our scientists to do more creative things with their time We are pleased that deCODE Genetics will continue using our TrueAllele software in their advanced bioinformatics processing says Dr Perlin Automated data scoring lets their scientists concentrate on high quality data generation and analysis enabling more rapid scientific discovery TrueAllele performs automated lane tracking and automated allele calling on gel image data from Perkin Elmer Applied Biosystems and other automated fluorescent DNA sequencers The software assesses the quality of every genotype it calls Version 2 1 runs on the UNIX Macintosh and Windows computer platforms deCODE genetics runs the TrueAllele software on LINUX and Windows NT Pentium computers Cybergenetics TrueAllele technology is

    Original URL path: http://www.cybgen.com/information/press-release/1999/deCODE-genetics-Renews-License-for-Cybergenetics-Automated-Genotyping-Technology/page.shtml (2016-02-12)
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  • Cybergenetics :: SmithKline Beecham Renews License for Cybergenetics Automated Genotyping Technology
    fully automated TrueAllele TM genetic analysis technology TrueAllele software eliminates the data scoring bottleneck for microsatellite genetic data Conventional manual data editing is the single greatest source of delay error and expense in high throughput genotyping says Dr Mark Perlin CEO of Cybergenetics Our computer based TrueAllele technology automates this data scoring and can greatly accelerate genetic discovery TrueAllele performs automated lane tracking and automated allele calling on gel image data from Perkin Elmer Applied Biosystems and other automated fluorescent DNA sequencers Version 2 0 runs on the UNIX Macintosh and PC computer platforms SmithKline Beecham runs the TrueAllele software on Compaq 64 bit Digital UNIX workstations We are pleased that SmithKline Beecham will continue to use our TrueAllele software in their advanced bioinformatics processing says Dr Perlin Automated data scoring eliminates one key bottleneck impeding rapid scientific discovery TrueAllele s computer based review of gels and genotypes helps scientists generate very high quality laboratory data Cybergenetics TrueAllele technology is protected by multiple patents The software is used at deCODE genetics Iceland and various academic and government laboratories for high throughput genotyping and gene discovery applications Cybergenetics is a bioinformation company based in Pittsburgh PA that develops unique computational approaches

    Original URL path: http://www.cybgen.com/information/press-release/1998/SmithKline-Beecham-Renews-License-for-Cybergenetics-Automated-Genotyping-Technology/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics Announces Automated Genotyping Evaluation Software
    automated lane tracking and automated allele calling on gel image data from Perkin Elmer Applied Biosystems and Pharmacia ALF automated fluorescent DNA sequencers and runs on the Macintosh UNIX and PC computer platforms Cybergenetics free evaluation CD lets scientists use the current TrueAllele v1 02 automated scoring software for three months before they license the technology Our Macintosh evaluation CD lets geneticists immediately use TrueAllele to speed up their gene discovery projects says Dr Perlin We have focused on simplicity and ease of use To install the user just copies the CD over to a hard drive TrueAllele then starts up with a single click Included is a PDF tutorial user manual which the user can browse as hypertext or read in printed hardcopy form The patented TrueAllele Technology is used at SmithKline Beecham UK deCODE genetics Iceland and various academic and government laboratories for high throughput genotyping and gene discovery applications Cybergenetics is moving its TrueAllele software beyond the usual gene discovery applications into forensics cancer genetics differential display and agricultural genetics The new version 2 0 software includes novel methods for determining allele frequencies from pooled DNA samples and improves performance by learning from past experience TrueAllele is

    Original URL path: http://www.cybgen.com/information/press-release/1998/Cybergenetics-Announces-Automated-Genotyping-Evaluation-Software/page.shtml (2016-02-12)
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  • Cybergenetics :: Cybergenetics Awarded SBIR Phase II Grant by NIH
    a two year Phase II SBIR grant of 749 905 to further develop its fully automated TrueAllele TM Technology genetic analysis software TrueAllele eliminates the data scoring bottleneck for microsatellite genetic data Conventional manual data editing is the single greatest source of cost and error in the high throughput genotyping process says Dr Mark Perlin CEO of Cybergenetics Our TrueAllele Technology automates this data scoring and greatly streamlines the gene discovery process TrueAllele performs automated lane tracking and automated allele calling on gel image data from Perkin Elmer Applied Biosystems and Pharmacia ALF automated fluorescent DNA sequencers and runs on the Macintosh and UNIX computer platforms Cybergenetics SBIR grant will extend TrueAllele to DNA sequencers from other manufacturers and to the PC computer Our SBIR grant will help Cybergenetics rapidly move beyond the usual gene discovery applications into forensics cancer genetics differential display and agricultural genetics says Dr Perlin We are including novel algorithms that will further advance TrueAllele s leadership position These computer based methods include determining allele frequencies from pooled DNA samples and improving performance by learning from past experience The patented TrueAllele Technology is used at SmithKline Beecham UK deCODE genetics Iceland and various academic and government

    Original URL path: http://www.cybgen.com/information/press-release/1998/Cybergenetics-Awarded-SBIR-Phase-II-Grant-by-NIH/page.shtml (2016-02-12)
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