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  • Cybergenetics :: Law
    Law M W Perlin Challenging DNA evidence Allegheny County Courthouse Continuing Legal Education Pittsburgh PA 27 Feb 2015 M W Perlin TrueAllele 174 Computing All the DNA all the time NSW Office of the Director of Public Prosecutions Continuing Professional Development Sydney Australia 19 Mar 2014 M W Perlin TrueAllele interpretation of Allegheny County DNA mixtures Allegheny County Courthouse Pittsburgh PA 28 Feb 2014 M W Perlin No DNA Left

    Original URL path: http://www.cybgen.com/information/education/law.shtml (2016-02-12)
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  • Cybergenetics :: Workshop
    News Major Projects Newsletters Newsroom Press Releases Trials Contact Directions Information Visiting Support FAQ File Transfer Sending Data Downloads Workshop J Hornyak W Allan and M W Perlin Using TrueAllele 174 Casework to separate DNA mixtures of relatives DNA Workshop 124th California Association of Criminalists San Francisco CA 20 Oct 2014 M W Perlin Revolutionising DNA analysis in major crime investigations The Investigator DNA Workshop Aylesbury Buckinghamshire UK 1 May

    Original URL path: http://www.cybgen.com/information/education/workshop.shtml (2016-02-12)
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  • Cybergenetics :: US8898021 B2
    claim 1 wherein the set of suspect genotypes contains a genotype of a convicted offender individual 19 The method as described in claim 1 wherein the determining step can process at least one DNA mixture per hour 20 The method as described in claim 1 wherein the determining step can determine a genotype using a computing device with memory 21 The method as described in claim 20 in performing the determining step does not exceed one hour 22 The method as described in claim 20 wherein the determining step is performed entirely by computer without any human intervention during the determining step 23 The method as described in claim 1 wherein the amplification includes a single nucleotide polymorphism SNP marker 24 The method as described in claim 1 wherein the analysis includes more than one DNA experiment 25 The method as described in claim 1 wherein the DNA mixture contains genetic material from more than two individuals 26 The method as described in claim 1 wherein the assuming step includes a candidate genotype selected from a database of previously determined genotypes 27 The method as described in claim 26 wherein the determining step produces a set of ranked genotypes that are in the database and match the data 28 The method as described in claim 1 wherein the amplifying step includes a low copy number PCR protocol 29 The method as described in claim 1 wherein the data variance model in the deriving step includes an inverse chi square probability distribution 30 The method as described in claim 1 wherein the probability of the quantitative genotyping data in the determining step is a multivariate normal distribution 31 The method as described in claim 1 wherein the probability of the quantitative genotyping data is combined with a genotype prior distribution to form a posterior genotype probability distribution 32 The method as described in claim 31 wherein the prior distribution is computed from population allele frequency information 33 The method as described in claim 31 wherein the prior distribution is uniformly distributed 34 A method as described in claim 1 where the quantitative genotyping data obtained in Step d is from a short tandem repeat STR locus 35 A method as described in claim 1 where the quantitative genotyping data obtained in Step d is from a Y chromosome short tandem repeat Y STR locus 36 A method as described in claim 1 where the quantitative genotyping data obtained in Step d is low copy 37 A method as described in claim 1 where the quantitative genotyping data obtained in Step d is derived from allele peak height or area 38 A method as described in claim 1 where the quantitative genotyping data obtained in Step d is derived from repeated experiments 39 A method as described in claim 1 where the quantitative genotyping data obtained in Step d entails fewer loci 40 A method as described in claim 1 where the genotype value assumed in Step e has an allele count

    Original URL path: http://www.cybgen.com/information/patent8.shtml (2016-02-12)
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  • Cybergenetics :: EP 1229135 B1
    for individual j w is a weight column vector that represents relative proportions of template DNA in the sample and e is an error vector wherein the solution includes calculation of data variance σ2 from the linear model d G w e together with the global minimal solution Pd Gw0 where Pd is the perpendicular projection point which is the closest point to d in mixture space C G and w0 is the minimum weight vector using linear regression methods and calculating a probability distribution of the data assuming a normal distribution and that the error is unbiased so that E e 0 but has a dispersion D e σ2 V in which V is the covariance matrix of the data and d determining using the probability distribution of the data a probability distribution of genotype likelihood or weight in the DNA sample 2 A method as claimed in claim 1 further including determining a statistical confidence in the information about the composition of the DNA mixture 3 A method as claimed in claim 1 further including recording a genotype likelihood or probability of an individual in a report 4 A method as claimed in claim 1 further including using a computing device to generate a visualization that shows the genotype matrix and the weight vector 5 A method as claimed in claim 1 further including comparing the genotype information with a set of suspect genotypes to identify a likely suspect 6 A method as claimed in claim 5 wherein the set of suspect genotypes contains a genotype of a convicted offender individual 7 A method as claimed in claim 1 wherein the speed of the method is such as to process at least one DNA sample per hour 8 A method as claimed in claim 1 wherein the speed

    Original URL path: http://www.cybgen.com/information/patent7.shtml (2016-02-12)
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  • Cybergenetics :: US6807490
    on different instruments can be confidently compared Genetic applications of this invention include gene discovery genetic diagnosis and drug discovery Forensic applications include identifying people and their relatives catching perpetrators analyzing DNA mixtures and exonerating innocent suspects CLAIMS What is claimed is 1 A method for analyzing a DNA mixture comprised of the steps a obtaining DNA profile data of a sample that comprises a DNA mixture of two or more individuals b representing the data and a genotype of the individuals contained in the DNA mixture in a set of linear equations c deriving a mathematical solution by performing a matrix operation on the linear equations and d determining the genotype at a locus of an individual contained in the DNA mixture from the mathematical solution 2 A method as described in claim 1 wherein the obtaining step a includes the step of performing a PCR on an STR locus of an individual 3 A method as described in claim 1 wherein the representing step b includes a matrix or vector representation of the set of linear equations 4 A method as described in claim 3 wherein the matrix representation has a term that includes a matrix multiplication of a genotype matrix and a weight matrix 5 A method as described in claim 1 wherein the deriving step c includes an optimization procedure 6 A method as described in claim 5 wherein the optimization procedure includes a minimization step 7 A method as described in claim 5 wherein the optimization procedure includes an arithmetic operation 8 A method as described in claim 1 wherein the determining step d produces an estimate of the genotype of an individual 9 A method as described in claim 8 wherein after the determining step d the estimated genotype is matched against a suspect

    Original URL path: http://www.cybgen.com/information/patent6.shtml (2016-02-12)
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  • Cybergenetics :: US6750011
    a computing device with a memory and d identifying an allele of the polymorphism 2 A method described in claim 1 wherein the analyzing step is conducted without human intervention 3 A method as described in claim 1 wherein the analyzing step is performed automatically 4 A method as described in claim 1 wherein after the identifying step there is the step of identifying an individual using the allele of the polymorphism in the individual using the allele of the polymorphism in the individual s nucleic acid material 5 A method as described in claim 1 wherein after the identifying step there is the step of comparing the allele with allele 6 A method a described in claim 1 wherein the analyzing step includes a method of least squares 7 A method as described in claim 1 wherein the analyzing step includes a maximum likelihood estimate 8 A method as described in claim 1 the analyzing step implements the linear model using a matrix equation 9 A method as described in claim 8 wherein the matrix equation compares the signal with a genotype 10 A method as described in claim 1 wherein the identifying step includes a deconvolution of the

    Original URL path: http://www.cybgen.com/information/patent5.shtml (2016-02-12)
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  • Cybergenetics :: US6054248
    fragments b separating the labeled DNA fragments by size to form a lane c detecting labeled DNA fragments to form part of an image represented as a set of signals in the memory of a computing device d obtaining expected locations of the size standard fragments in the image e operating a processor of a computing device with memory on the image and the expected locations to form a comparison and f determining from said comparison where a lane or DNA fragment size is located in the image 2 A method as described in claim 1 wherein the operating step simultaneously processes two dimensions in the image 3 A method as described in claim 1 wherein the labeled DNA fragments include a labeled DNA sample fragment derived from a DNA sample and after the determining step there are the steps of g detecting a labeled DNA sample fragment in the image to form a second set of signals in the memory of a computing device h operating a processor of a computing device on the second set of signals and on the determined location of a lane or DNA fragment size in the image to form a second comparison and i estimating from the second comparison a physical property of the labeled DNA sample fragment corresponding to a DNA size or a DNA concentration 4 A method as described in claim 3 wherein the estimated physical property of the labeled DNA sample fragment corresponds to a DNA size or a DNA concentration 5 A method as described in claim 3 wherein after the estimating step i there is the step of using the estimated property in a genetic analysis to identify a gene 6 A method for genotyping comprised of the steps a obtaining DNA or RNA material from a

    Original URL path: http://www.cybgen.com/information/patent4.shtml (2016-02-12)
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  • Cybergenetics :: US5876933
    concentrations of the amplified material from different locations having the same size and the PCR stutter patterns of the different locations provide the primary mechanism for genotyping the locations 12 A method as described in claim 1 wherein the operating step makes use of a second set of electrical signals corresponding to response patterns of the locations 13 A system for genotyping comprising a means for obtaining nucleic acid material from a genome b means for amplifying locations of the material to generate a reproducible pattern a reaction vessel within said amplifying means in contact with the nucleic acid material c means for assaying the amplified material said assaying means in contact with the reaction vessel d means for converting the assayed amplified material into a first electrical signal said converting means in communication with the assaying means and e means for operating on the first electrical signal with a second electrical signal to form a third electrical signal said operating means in communication with the electrical signals 14 A system as described in claim 13 wherein a the amplifying means includes polymerase chain reaction or harvesting cloned cells b the assaying means includes gel or ultrathin gel electrophoresis or mass spectroscopy or denaturing gradient gel electrophoresis or differential hybridization or sequencing by hybridization c the converting means employs labeling with detection including radioactivity or fluorescence or phosphorescence or chemiluminescence or visible light or ions or pH or electricity or resistivity or biotinylation or antibodies and includes the detecting means or mechanism which includes a photomultiplier tube a radioactivity counter a resistivity sensor a pH meter or an optical detector and d the operating means includes statistical moment determinations or Fourier transformation or optimal filtering or polynomial calculations or matrix computations 15 A method for analyzing genetic material of an organism comprising the steps of a obtaining nucleic acid material from the organism b amplifying locations of the material to generate a reproducible pattern c labeling the amplified material with labelsl d converting the labels with a sensing device which produces a first electrical signal and e producing the genotype of an amplified location of the genetic material in an electronic acquisition system comprising a region having a radius of less than five feet at a rate exceeding 100 genotypes per hour 16 A method as described in claim 1 wherein the step of operating on the first electrical signal includes the step of determining a numerical value corresponding to an error 17 A method as described in claim 1 wherein the step of producing the genotype includes the step of determining a numerical value corresponding to the genotype accuracy 18 A method as described in claim 1 wherein the step of operating on the first electrical signal includes forming a first third electrical signal and a second third electrical signal and the step of producing a genotype includes a comparison of the first and second third electrical signals 19 A method of determining the risk of genetic disease comprising

    Original URL path: http://www.cybgen.com/information/patent3.shtml (2016-02-12)
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