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    Original URL path: /MultipleMutations.htm (2016-02-12)




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    Original URL path: /mufeatur.htm (2016-02-12)


  • RFLP Mutation Rates
    mutations meioses D1S339 58 8345 0 70 11 4212 0 26 D2S44 59 63848 0 09 94 63542 0 15 D4S139 144 22893 0 63 2 14194 0 01 D4S163 3 2703 0 11 no data D5S110 3 544 0 55 6 388 1 55 D7S467 7 1988 0 35 1 1630 0 06 D10S28 40 60895 0 07 116 64331 0 18 D12S11 2 2105 0 10 1 2100

    Original URL path: http://dna-view.com/mutext.htm (2016-02-12)
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    Original URL path: /mutation.htm (2016-02-12)




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    Original URL path: /SNPpost.htm (2016-02-12)


  • DNA sampling variation
    count for each allele approximate one standard deviation confidence interval Note that the formula doesn t involve the database size or the allele frequency just the count Example TH01 VWA allele 6 9 12 14 frequency 31 226 28 226 5 226 48 226 times observed k 31 l 28 m 5 n 48 Uncertainty exp sqrt 1 31 1 28 1 5 1 48 1 7 This figure is divided into and multiplied by the profile frequency The profile frequency is 2 31 226 28 226 2 5 226 48 226 which comes to one person in 3131 Taking the uncertainty factor of 1 7 one standard deviation confidence into account it is reasonable to think that something like one person in 2000 to 5000 would have the profile Moral The calculated profile frequency does not have even one decimal digit of accuracy Approximate Mathematics Uncertainty being necessarily vague it offers a great chance for some approximate mathematics Therefore don t expect any right answers on this page just simple ones And close enough NRC formulas The NRC II report gives more complicated and less approximate formulas than my simple recommendation Their formulas give smaller confidence intervals For example with six rare alleles each of frequency 5 200 I would say that the profile is most probably rarer than one person per hundred million the NRC can say per three hundred million For a common profile six alleles each with a frequency of 50 200 I say once per 450 people while they give the stronger information of once per 500 people I think the difference is slight and the extra accuracy is not worth the trouble considering the loss in simplicity and intuitiveness The NRC formulae also look very different but that s an illusion Just replace each

    Original URL path: http://dna-view.com/dnafreq.htm (2016-02-12)
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