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  • Errata -- examples of bias
    as to the standard distribution of a population I incorrectly gave n 1 instead of n 1 in the heat of the lecture which is nonsense Did I also omit the symbol Heterozygosity The heterozygosity example was at best very unclear The intended idea is this Suppose that at a particular locus nature provides two alleles A 1 and A 2 with frequencies p and q 1 p which unknown to us are We assume HWE for the locus in question so the rate of heterozygosity h is also although we don t know that number either We propose to estimate h the rate of heterozygosity by a sampling experiment The experiment consists of examining a sample of size n Now if we were to calculate the proportion of heterozygotes in the sample by counting them and dividing by n we would get an estimate of the population heterozygosity that would be sometimes too large and sometimes too small but on the average would be just right If we did that there would be no story What we decide to do instead is to take advantage of our assumption of HWE and to estimate the population heterozygosity based on the allele frequencies in the sample In principle this rates to give a more accurate estimate of h However this idea will give a biased answer if we apply it in the obvious way To see the problem let s consider as an example the case of n 1 a sample of only one person The sample will have one of three genotypes Case A 1 A 1 In this case which occurs 1 4 of the time we would estimate the gene frequencies as p 1 and q 0 hence h 2 pq 0 An underestimate Case A 1 A

    Original URL path: http://dna-view.com/errata.htm (2016-02-12)
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  • Random Quotations
    Home page of Charles Brenner Suggestion Correction Boswell on Johnson on Lawyering

    Original URL path: http://dna-view.com/quotes.htm (2016-02-12)
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  • Index of /downloads/documents/RareHaplotypes
    Index of downloads documents RareHaplotypes Parent Directory 2012 Rare Haplotypes pptx Critique haplotype A4 pdf Y haplotype abstract doc rare haplotype narrative pdf

    Original URL path: http://dna-view.com/downloads/documents/RareHaplotypes/ (2016-02-12)
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  • com downloads validation Compliance Y2K 3 1 doc 100 04 29 15 48 B J oldftp validation tabels val acc questionnaire 1998 doc dna view com downloads validation tabels val acc questionnaire 1998 doc 100 04 29 15 48 B J oldftp validation Validation GeneScan import 1 1 doc dna view com downloads validation Validation GeneScan import 1 1 doc 100 04 29 15 48 B J oldftp validation Validation

    Original URL path: http://dna-view.com/downloads/validation/WS_FTP.LOG (2016-02-12)
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