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  • Eigenvector Research: Chemometrics Software, Consulting and Training
    widest available array of data preprocessing and analysis methods with transparency and freedom to customize all at the best price performance ratio in the industry Choose from our stand alone or MATLAB based packages Multivariate calibration and pattern recognition with PLS Toolbox and Solo Image analysis with MIA Toolbox and Solo MIA On line predictions with Solo Predictor and Model Exporter Additional advanced and Custom Software Tools Plus Our software engineers are also scientists and trainers and they staff our much lauded software helpdesk Our Technology Partners also use our software with their instruments and services Consulting Experienced Consultants for Every Environment Our consulting staff has 100 man years experience applying chemometric techniques in a wide variety of applications including Chemical processes Semiconductor Consumer products Analytical instrument development Pharmaceutical Medical devices Oil chemical Metal minerals Food beverage Plastics PAT Process Analytical Technology Hyperspectral imaging remote sensing Electronic nose sensor development Training At EVRI we believe that the best data analysts are the people that own the data and understand the chemistry and physics behind it That s why we re always pleased to teach chemometrics to analytical chemists and engineers involved in discovery through implementation Just announced The Sixth Annual Eigenvector Univerisity Europe will be October 24 27 in Montpellier FRANCE The 11th Annual Eigenvector University runs April 24 29 at the fabulous Washington Athletic Club in beautiful Seattle Washington Join PLS Toolbox creator Barry M Wise Eigenvector Associate Rasmus Bro and the entire EVRI staff for six days of courses and events This year s EigenU features 16 courses from basic to advanced Three new courses debut this year Managing Data Models Plots Interfaces in PLS Toolbox Model Deployment with Solo Predictor Model Exporter Chemometric Methods for GC MS and LC MS To register just log in to your

    Original URL path: http://www.eigenvector.com/ (2016-04-27)
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  • Support - Eigenvector Research, Inc.
    techincal getting started EigenGuide videos can be viewed on line here Contacting Us for Support Web File a support request from the Support tab through your account on our website E mail Reach our technical support team for fast customized support for any Eigenvector Research software product by writing to helpdesk eigenvector com Orders Invoices Support To recieve help regarding an order you have placed or want to place or

    Original URL path: http://www.eigenvector.com/support.htm (2016-04-27)
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  • About Eigenvector Research, Inc.
    tools and support for a wide variety of industries Our Goal Be your complete source for state of the art chemometrics tools and know how Our Strategy Enlist the best possible team of chemometrics research consulting and software development scientists and engineers to create superior data analysis options that apply modern multivariate statistical methods to your data while keeping a firm grasp on the underlying chemical physical and biological aspects of the system EVRI Associates Our associates program facilitates one stop access to the best chemometrics talent worldwide equipping EVRI with exactly the right expertise to fulfill your needs Each of our associates is a world leader in his field Our current associates include Rasmus Bro multi way analysis Don Dahlberg chemometrics education food products analysis For more information about Eigenvector Associates please contact Barry M Wise EVRI Co Founders Barry M Wise Ph D President and Founding Partner creator of PLS Toolbox Specialty Consulting short course instruction research product development Neal B Gallagher Ph D Vice President and Founding Partner co author of PLS Toolbox Specialty Consulting short course instruction research product development EVRI Technical Staff Robert T Roginski Ph D Lead Consultant and Chief of Online Applications Specialty

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  • Company Overview - Eigenvector Research, Inc.
    in October 1985 the first day of a graduate math class at the University of Washington They founded Eigenvector Research on January 1 1995 Both men have broad experience modeling chemical systems using theoretical and empirical approaches Software Wise first developed EVRI s flagship chemometrics software PLS Toolbox in 1989 More than 20 years later Eigenvector Research continues to set the standard in powerful data analysis solutions software by providing extremely flexible comprehensive and easily customizable configurations for use in a wide variety of applications and operating systems Consulting Software is just one component of Eigenvector s winning equation EVRI is well known for no nonsense unbiased and efficient consulting Wise Gallagher and EVRI staff have 100 man years experience with Multivariate Analysis and have enjoyed the privilege of working with clients globally Short Courses Training Eigenvector Research offers chemometrics short courses for chemists and engineers who want to be able to analyze their own laboratory or process data or develop their own data models Conferences client sites and EVRI s annual EigenU are among the many opportunities to take advantage of this comprehensive training In addition technical support is available online 24 7 History 1989 Development of PLS Toolbox

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  • Partners - Eigenvector Research, Inc.
    Exporter Brimrose is the world leader in Electro Optic technology with OEM commercial and R D activities that include all major photonic applications They have addressed the rapid growing need of various fiber optic components and offer AOTF Hyperspectral Imagers for imaging spectroscopy ecophysiological and agricultural applications We have partnered to provide easy implementation of PLS Toolbox and Solo models in the hand held line of Brimrose analyzers HORIBA Scientific is a global team created to better meet customers present and future needs by integrating the scientific instrumentation and applications expertise and resources of HORIBA HORIBA Scientific offerings encompass a wide range of analytical instrumentation including Fluorescence Raman and Glow Discharge Optical Emission Spectroscopy Horiba is a distributor of Eigenvector Research software products including embedded analysis solutions and off the shelf products and a partner in our consulting services Applied Instrument Technologies AIT delivers process analytical technology solutions to the leading companies of the world They design and manufacture robust process development and on line analyzers for quantitative and qualitative analysis including FTIR FTNIR NIR Raman Process Gas Chromatography and Mass Spectrometer systems AIT is a reseller of the PLS Toolbox Solo and Solo Predictor software interfaces with Solo Predictor and PLS Toolbox as prediction engines and uses Eigenvector Research technology for their SpectraQuant software Indatech provides innovative optical solutions for characterizing inline complex products such as liquids e g mammalian cells or particles in suspension or solids tablet patches powder polymer and composite cookies for the biotech pharma petrochemical and food industries The technology relies on patented spatially resolved spectroscopy approach SAM Spec and SAM Flex hyperspectral imaging and Raman Hy ternity system can analyze products in line and without contact at less than 0 3ms Eigenvector Research and Indatech partner to provide hyperspectral imaging solutions with Solo MIA and process analysers with SynTQ and Solo Predictor Cobalt Light Systems develops products and technology for non invasive sub surface analysis Cobalt s instruments analyse the contents of intact tablets and capsules in seconds screen containers for security threats and identify the contents of unopened sacks bottles and tubs Cobalt s TRS100 pharmaceutical analysis instrument and its ContentQC software uses Eigenvector Research s Solo product for chemometric analysis JDSU Optical Security and Performance Products group develops and delivers high value optical components and solutions that enhance the security safety and other performance attributes of its customers products The MicroNIR spectrometer is an ultra compact near infrared NIR spectrometer that supports on site non destructive point of use and rapid material identification as well as constituent quantification of food feed industrial and chemical materials The dispersing element detector light source collection optics and electronics are fully integrated in one small USB powered palm size device weighing less than 60 grams JDSU partners with Eigenvector to provide easy access to the Solo product family from their analyzers Kaiser Optical Systems Inc is a world leader in spectrographic instrumentation and applied holographic technology Principal products include Raman sensors and instrumentation advanced holographic components

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  • The View from Eigenvector
    never seen my office that clean I really enjoyed the process I always get really enthusiastic when I start talking about Eigenvector BMW Read More Posted by barry No Comments yet Categories Eigenvector News 2nd Mar 2015 EigenU 2014 Poster Contest Winners Each year Tuesday evening at Eigenvector University features the PLS Toolbox Solo User Poster Session Prizes are given for the two best posters as judged by the Eigenvector staff associates and guest instructors At EigenU 2014 there were 10 posters presented by users plus a couple more from EVRI which made for a very lively session Associate Rasmus Bro and guest lecturer Age Smilde who was there to lead the Chemometrics in Metabolomics course assisted the Eigenvectorians in choosing the best posters The winners were Eric Massicotte of the Canada Border Services Agency CBSA and Sarah Nielsen of Janssen Supply Group Massicotte displayed Determination of the Geographic Origin of Tobacco Leaves by NIR A Partial Least Squares Discriminant Analysis PLS DA model based on the NIR spectra of flue cured tobacco leaves was developed that classified the samples into the 10 countries of origin The sensitivity and specificity of the model was found to be greater than 0 92 for all classes except the USA group which has the largest variability The technique may be used in the future as a screening tool by the CBSA Nielsen presented Distribution Analysis of Components in the EVRA Patch by Confocal Raman Microscopy which she developed with her co author Amber Mantz Confocal Raman Microscopy CRM images were generated at various locations within EVRA samples to charaterize drug product and excipient distributions PLS models were developed to predict relative drug concentration in the patches Samples were analyzed from time of manufacture to product expiry to determine if changes in drug concentrations occurred The models indicated that there were no significant changes over the life of the product Nielsen and Massicotte each received an Apple iPod nanos engraved with Eigenvector University 2014 Best Poster for their efforts Good work and thanks to everybody that presented at EigenU 2014 BMW Read More Posted by barry No Comments yet Categories Eigenvector News Short Courses 25th Feb 2015 Chemometrics Consultant position opening at Eigenvector Research Eigenvector Research Inc EVRI has an opening for a full time Chemometrics Consultant staff member Applicants should have a M S or Ph D degree in Chemistry Chemical Engineering or a closely related field and at least five years experience developing chemometric models Experience in the pharmaceutical chemical medical device food and beverage or bioinformatics fields would be useful Practical knowledge of analytical techniques especially spectroscopy required Must be proficient in MATLAB Experience with Javascript HTML CSS and other programming languages would be a plus Experience with EVRI s software especially PLS Toolbox and MIA Toolbox sought Experience with other chemometrics packages also a plus Teaching experience desired The successful candidate is expected to take a lead role on some chemometrics consulting projects and a supporting role on others Must be able to meet with potential clients understand their goals and needs develop a statement of work and execute the tasks Good written and oral communications skills especially the ability to convey complex information to non experts required Potential to attract new projects through new and existing contacts preferred Must be able to work at home Location not critical but proximity to our existing locations would be a plus EVRI employees enjoy working on interesting projects with a dedicated fun and lively team of chemometrics and programming experts EVRI offers a competitive salary and benefits package plus flexible hours and the ability to work at home Applicants should send a C V and letter of interest to Barry M Wise Read More Posted by barry No Comments yet Categories Chemometrics Eigenvector News 19th Feb 2015 Eigenvector Turns 20 Eigenvector Research Inc aka EVRI passed a significant milestone when we turned 20 years old on January 1 2015 The event passed without a lot of fanfare around here Frankly we were just all a little bit too busy to do much beyond offering a few internal congratulations Eigenvector was founded on January 1 1995 when Neal Gallagher and I used our credit cards to buy computers and office furniture Neal was living with us in West Richland WA and that became our first offices Our original plan was that we would be primarily a consulting company and also continue to develop our MATLAB based PLS Toolbox Our first two consulting projects were for Pacific Northwest National Laboratory PNNL where we had both been employed The first involved development of models based on FTIR spectroscopy to estimate the organic gas content and ozone forming potential of automobile exhaust The second was analysis of the behavior of waste tank SY 101 Hanford s notorious burping tank We soon discovered that there was a significant demand for chemometrics courses The field was relatively new and lots of companies wanted to take advantage of the possibilities that multivariate analysis opened up I had taught a chemometrics course at the Joint Center for Graduate Study now Washington State University Tri Cities and was happy to take it on the road Thus we became the three legged stool that we are today providing chemometric software consulting and training In 2001 we made the first addition to our technical staff with Jeremy M Shaver now our Chief of Technology Development This was possibly the best decision we ve ever made Under Jeremy s stewardship PLS Toolbox has developed into the user friendly and comprehensive package that it is today Plus we ve added our stand alone Solo tools for Multivariate Image Analysis and on line predictor packages Solo Predictor and Model Exporter Our software sales have grown continuously for more than a decade and now comprise the largest third of our business We now have 2500 users in more than 1000 companies and universities across 50 countries We joke sometimes that we founded EVRI because life is too short to drink bad beer do boring work or live in a crappy place But there s an element of truth in that We ve gotten to work on some fascinating projects over the last 20 years Some frustrating ones as well but on average pretty interesting stuff We d like to think we ve done some good in that we ve trained a lot of chemometricians provided tools that make their work easier and advanced projects that have made processes more efficient and benefited consumers and patients We look forward to continued growth and more stimulating projects over the next 20 years BMW Read More Posted by barry No Comments yet Categories Eigenvector News 22nd Oct 2014 Nonlinear Model Support Added to Model Exporter Model Exporter is EVRI s software for turning multivariate chemometric models into formats which can be compiled into online applications It offers an alternative to our stand alone prediction engine Solo Predictor Model Exporter allows users of our MATLAB based PLS Toolbox and stand alone Solo to easily create a numerical recipes of their models These recipes give the step by step procedure that take a measurement and calculate the desired outputs such as concentration class assignment prediction diagnostics etc This includes applying all preprocessing steps along with the model PCA PLS PLS DA etc itself When Model Exporter is installed models can be exported into predictor files in a variety of formats via the file menu in the Analysis window as shown below Model Exporter also includes two versions of the freely distributable Model Interpreter Either the C or Java version of the Model Interpreter can be used by any 3rd party program to add the ability to parse an exported model in XML format Simply point the interpreter at an XML exported model and supply the data from which to make a prediction The interpreter applies the model and returns the results Model Interpreter has no licensing fees and is appropriate for use on standard processors and operating systems or on handheld devices run by reduced instruction set processors e g ARM Your application doesn t need to know anything about the preprocessing or model being used Version 3 0 of Model Exporter was released in early October along with its associated stand alone Solo Model Exporter version 7 9 This release includes support for Support Vector Machine SVM regression and classification models as well as Artificial Neural Network ANN regression models These changes represent a significant addition to Model Exporter making it even more unique in the chemometrics world No other chemometric modeling product offers anything as transparent flexible or unencumbered by licensing You can get more info about Model Exporter by consulting the Release Notes and the Model Exporter Wiki page Users with current maintenance can access these versions now from their account If expired maintenance can be renewed through the Purchase tab If you have any questions feel free to write us at orders eigenvector com BMW Read More Posted by barry No Comments yet Categories Chemometrics Eigenvector News Software 20th Oct 2014 Classical Least Squares CLS with Nonlinear Spectra In the last several years we ve seen a resurgence of interest in Classical Least Squares CLS modeling To address that our Neal Gallagher is developing a course on CLS Methods for the next EigenU Our interest also stems from the fact that we ve worked on a number of consulting projects where CLS models are appropriate for calibrating spectroscopic systems As you might expect these systems are relatively simple mixtures in gas or liquid phase Recall the CLS model is X CS E where X is the measured spectra C is the matrix of concentrations S is the pure component spectra and E is noise Complicating matters a bit several of the systems we ve worked with exhibit significant nonlinearities due to high absorbance features In spite of that CLS models can work quite well if set up correctly What follows is an example that demonstrates this which I originally did just to clarify how this works in my own mind Suppose you have a single component system with a pure component response that is a simple Gaussian peak centered in the spectral range with a maximum value of one when the concentration is also one Furthermore suppose that the spectra is linear up to an absorbance of one but rolls off after that For x ideal 1 I used x measured 2 exp x ideal 1 but the exact form of the nonlinearity isn t critical The measured spectra for concentrations from 0 to 3 is shown below with concentration 1 shown as the thick blue line It is apparent that the shape changes as the concentration exceeds 1 If the concentration is estimated using the ideal concentration If the ideal response for each concentration is estimated then the difference between it and the observed response can be calculated as shown in the top panel in the figure below Because each difference spectra has a slightly different shape the rank of this difference matrix is equal to the number of samples exhibiting non linear behavior which in this case is 20 the samples with concentration 1 1 to 3 However it is easy to get a basis for the nonlinear deviations using the Singular Value Decomposition SVD Furthermore the singular values indicate that 93 7 of the residual sum of squares is captured in the first factor and 98 6 is captured in the first two The ideal response along with the first two basis vectors is shown lower panel When the CLS model is augmented with the two basis vectors the prediction improves dramatically The figure below shows the predicted concentration of the analyte as well as the concentration of the two additional basis vector factors The correction added by the 1st nonlinear factor becomes quite large at high concentrations whereas the contribution of the 2nd nonlinear factor remains relatively small The prediction error in the concentration of the analyte is less than 1 In a future blog post we ll explore some other aspects of CLS models BMW Read More Posted by barry No Comments yet Categories Chemometrics Short Courses 7th Oct 2014 MATLAB R2014b and PLS Toolbox 7 9 The MathWorks released MATLAB R2014b version 8 4 last week and right on its heels we released PLS Toolbox 7 9 R2014b has a number of improvements that MATLAB and PLS Toolbox users will appreciate specifically with graphics The new MATLAB is more aesthetically pleasing to the eye easier for the Color Vision Deficiency CVD challenged and smoother due to better anti aliasing An example is shown below where the new CVD friendly Parula color map is used to indicated the Q residual values of the samples But the most significant changes in R2014b are really for people like us that program in MATLAB For instance TMW didn t just change the look of the graphics they actually changed the entire handle graphics system to be object oriented They also added routines useful in big data applications and improved their handling of date and time data When you start the new MATLAB the command window greets you with this Some existing code may need to be revised to work in this version of MATLAB That is something of an understatement In fact R2014b required the update of almost every interface from PLS Toolbox 7 8 Revising our code to work with R2014b required hundreds of hours But the good news for our users is that we were ready with PLS Toolbox 7 9 when R2014b was released AND as always we made our code work with previous versions of MATLAB back to R2008a This of course is the significant difference between a supported commercial product and freeware Not only do you get new features regularly but you can rely on it being supported as operating systems and platforms change So if you look at the Version 7 9 Release Notes you won t see a lot of major changes Instead we took the time to assure compatibility with R2014b and made many minor changes to improve usability and stability The new MATLAB will allow our command line and scripting users to do their science more efficiently and present their result more elegantly These improvements will benefit us as well and will ultimately translate into continued improvement in PLS Toolbox and Solo BMW Read More Posted by barry No Comments yet Categories Chemometrics Eigenvector News Software 6th Jan 2014 Eigenvector Starts 20th Year On New Year s day 2014 Eigenvector Research Inc EVRI celebrated its 19th birthday and began its 20th year The momentum that carried us into 2013 built throughout the year and resulted in our largest year over year software sales increase since 2007 Our best three software sales months ever have all been within the last five months Clearly our partnering with analytical instrument makers and software integrators plus our tools for putting models on line are striking a responsive chord with users The consulting side of our business also continues to be very busy as we assist our clients to develop analytical methods in a wide variety of applications including medical pharmaceutical homeland security threat detection agriculture food supplements energy production and more The third leg of our business chemometrics training continued unabated as we taught on site courses for government and industry courses at conferences and held the 8th edition of our popular Eigenvector University EigenU We enter 2014 firing on all cylinders Major additions to PLS Toolbox and Solo in 2013 included the Model Optimizer Hierarchical Model Builder a new Artificial Neural Network ANN tool and several new file importers We will soon release an additional ANN option along with new tools for instrument standardization calibration transfer Also on the horizon a major new release of Solo Predictor will include an enhanced web interface option and additional instrument control and scripting options 2014 includes a busy schedule with conferences talks conference exhibits and short courses Below is a listing of where you ll be able to find us January 21 24 IFPAC Arlington VA BMW to present Mixed Hierarchical Models for the Process Environment and A Multivariate Calibration Model Maintenance Road Map March 2 6 Pittcon Chicago IL NBG and RTR will be at the EVRI exhibition booth April 27 May 2 EigenU 2014 9th Annual Eigenvector University Seattle WA Join the complete EVRI staff for 6 days of courses and events May 6 9 EuroPACT Barcelona Spain BMW to give plenary address Model Maintenance the Unrecognized Cost in PAT and QbD and a condensed version of our Chemometrics without Equations short course June 1 4 CMA4CH Taormina Italy JMS to teach short course and talk TBD June 8 12 CAC XIV Richmond VA NBG and RB to teach Advanced Preprocessing for Spectroscopic Applications and Alternative Modeling Methods in Chemometrics August 2 8 IDRC Chambersburg PA NBG to attend talk TBD September 14 18 ICRM Nijmegen The Netherlands NBG to give keynote An Overview of Hyperspectral Image Analysis in Chemometrics September 28 October 3 SciX 2014 Reno NV JMS Chemometrics Section Chair talks and courses TBD November 10 13 EigenU Europe Hillerød Denmark Courses led by BMW and Eigenvector Associate Rasmus Bro November 17 19 EAS 2014 Somerset NJ EVRI sponsor of Award for Achievements in Chemometrics Courses and talks TBD We re especially excited about this year s Eigenvector University This ninth edition of EigenU will include all our usual events poster session PowerUser Tips Tricks workshop dinner plus five new short courses Special guest Age Smilde will lead Chemometrics in Metabolomics and Rasmus Bro will present Modeling Fluorescence EEM Data The other three new courses are Calibration Model Maintenance PLS Toolbox Beyond the Interfaces and Getting PLS Toolbox Solo Models Online We expect EigenU 2014 to be an especially fun and fruitful learning experience We look forward to working with you in 2014 BMW Read More Posted by barry

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  • Applications - Eigenvector Research, Inc.
    Based on our Solo Predictor engine and AJAX technology the web page automatically queries a central database and applies specified PLS Toolbox Solo models to the data The results are displayed in tabular or graphical format with the ability to drill down to contributions and or raw data The interface includes high level Manager views mid level Engineer views and expert level Detail views Customized Solo for a pharmaceutical laboratory application Client supplied clustering and visualization algorithms were added to our standard Solo package along with application specific flowcharts to help less experienced lab personnel run the system The package is intentionally limited in the methods which are available so as to help guide users to the specific actions necessary for the application The result is a package which the client could easily distribute within their research division with minimal training requirements more The custom application makes use of our flexible flowcharting frame among many other customizable features of our GUIs Customized Solo for bundling with semiconductor instrumentation A highly customized version of Solo was supplied for bundling with a semiconductor manufacturing company s instruments This package included a custom automatic data importing routine specialized preprocessing options application specific automatic analysis tools developed by Eigenvector Research command line utility to automatically generate models and custom import export format for models Biological system automated preprocessing and modeling scripts Working closely with the client Eigenvector Research developed application specific preprocessing scripts to help automate model development and evaluation for a complicated biological system Eigenvector s experience in real life applications scientific instrumentation experimental design and chemical and biological systems allowed us to work in concert with the client s technical staff These scripts were developed using PLS Toolbox for Matlab and included training of the client s staff on their use as well as development of calibration protocols Novel library search algorithm for embedded application A custom clustering and classification search algorithm was developed for a hand held device The algorithms were specifically developed in close contact with client engineers to allow implementation on a low memory low power embedded computer and easy expansion to additional applications Customized high speed model deployment Model deployment software was designed for and integrated with an existing customized data logging client to support a sensor array development project This custom software which utilized Matlab engine functions enabled parallel deployment and evaluation of multiple calibration models at a high execution rate 1 Hz Remote sensing hyperspectral scene generator EVRI developed a hyperspectral scene generator for testing of remote sensing algorithms The InfraRed Systems in General Environments IR SAGE platform was created to incorporate the real life physics of remote sensing and library spectra Our staff developed the mathematical models and graphical environment to create sophisticated test data which greatly reduced the development time for hyperspectral models more D M Sheen N B Gallagher P G Heasler J F Schultz B M Wise S W Sharpe and K K Anderson Infrared Chemical Detection Systems Modeling and Advanced Chemometric

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  • Eigenvector Research, Inc.
    Site Search for Consulting Services Eigenvector Research provides advanced chemometric support for chemical process industries consumer product manufacturers and analytical instrument developers Clients range from semiconductor manufacturers and analytical instrument companies to pharmaceutical oil and chemical companies EVRI s staff and associates bring decades of multivariate analysis experience to your project Contact us for more information Example Applications Spectroscopic calibrations Process modeling for optimization Process models for monitoring and fault

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