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  • Ultra-fast measurement for remote sensing, spectroscopy and imaging - Isis Innovation
    Material Reagent Sales Easy to use Materials Evaluation Agreement Investment Opportunities Technology investment opportunities Information for Investors Isis Innovation spinouts Oxford Invention Fund University of Oxford Isis Funds Oxford University Consulting Services Academic consulting advice Academic Expertise Showcases Technical Services Technical Services Showcases OUC Clients For University members Contact OUC Innovation Consultancy Technology Transfer Commercialisation Training Technology Transfer Services Technology Commercialisation Innovation Management Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Ultra fast measurement for remote sensing spectroscopy and imaging Share this Ultra fast measurement for remote sensing spectroscopy and imaging Oxford researchers have developed a measurement technique that overcomes the speed limitations of traditional optical instruments and enables fast continuous single shot measurements in optical sensing spectroscopy and imaging This invention maps the spectrum of an optical pulse to a temporal waveform whose intensity mimics the spectrum thus allowing a single pixel photodetector to capture the spectrum at a scan rate significantly beyond what is possible with conventional space domain spectrometers The technique has previously been established using a dispersive medium such as fibre optic cable This technique removes the need for the fibre optic dispersive medium operating in free space resulting in a tuneable device operating across all optical wavelengths with potentially higher sensitivity than previous devices The invention may provide significant improvements in sensitivity particularly at wavelengths that are absorbed by fibre optic cable This invention could result in an improvement of a variety of scientific industrial and biomedical applications in the form of spectroscopy imaging laser scanning and analogue to digital technology Increasing demand for high speed instruments capable of capturing fast transient events is becoming popular Therefore spatial or spectral to temporal measurement is expected to be useful for high throughput screening and studying non repetitive rare phenomena for which conventional pump probe methods fall short due to their requirement for repetitive events This includes a diverse range of applications that require fast continuous measurements including the absorption spectroscopy of combustion engines the characterisation and control of optical rogue waves imaging laser ablation the identification of rare cancer cells in blood the surface vibrometry of microelectromechanical systems high throughput OCT for manufacturing and process control and analog to digital conversion for wide bandwidth communications in defence Examples of uses include Real time spectroscopy continuous single shot measurements of rapidly evolving or fluctuating spectra at a scan

    Original URL path: http://isis-innovation.com/licence-details/ultra-fast-measurement-for-remote-sensing-spectroscopy-and-imaging/ (2016-05-01)
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  • Microfluidics for the Life Sciences - Isis Innovation
    University Consulting Services Academic consulting advice Academic Expertise Showcases Technical Services Technical Services Showcases OUC Clients For University members Contact OUC Innovation Consultancy Technology Transfer Commercialisation Training Technology Transfer Services Technology Commercialisation Innovation Management Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Microfluidics for the Life Sciences Share this Microfluidics for the Life Sciences As our analytical techniques improve over time we can detect ever smaller amounts of the substances we are interested in Accordingly we can work with smaller and smaller quantities of these materials and this is particularly advantageous in fields where these materials are expensive or hazardous Working with smaller quantities means more science can be done e g more drug screens performed with the limited time equipment and materials we have This fundamental driver has led to widespread interest in the field of microfluidics which facilitates work at this scale Despite its promise the interest surrounding microfluidics has been disappointing due to limitations on biocompatibility difficulty with integrating these techniques with proven life science workflows and complexity associated with making and promoting the lab on a chip devices which have been produced so far Oxford researchers have developed improved microfluidic circuits which address and overcome the limitations of current lab on a chip technology Multidisciplinary challenge Wikipedia describes microfluidics as a multidisciplinary field intersecting engineering physics chemistry biochemistry nanotechnology and biotechnology The prefix micro is used here to highlight that fluid working volumes are small from microliters down to femtolitres the physical dimensions and energy requirements are small and the effects of the micro domain predominate Microfluidics deals with the behaviour precise control and manipulation of fluids in this sub millimetre world Despite countless proof of concept demonstrations recent reviews of the microfluidics field have concluded that despite their initial promise there has been limited success in translating microfluidic lab on a chip devices see image into useful products There are several reasons for this including complexity lack of flexibility devices can take days to manufacture and are generally dedicated to a single purpose inferior biocompatibility and difficulty in integrating with existing workflows Life Sciences compatibility A team of University of Oxford researchers with physical and life sciences expertise have collaborated to provide for the first time a microfluidics approach which starts from the requirements of a working life scientist to overcome the constraints of existing lab

    Original URL path: http://isis-innovation.com/licence-details/microfluidics-for-the-life-sciences/ (2016-05-01)
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  • Combination therapy to slow brain atrophy - Isis Innovation
    FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Combination therapy to slow brain atrophy Share this Combination therapy to slow brain atrophy Age related cognitive decline is becoming increasingly common with Mild Cognitive Impairment MCI affecting around 16 of those over 70 years old Researchers at the University of Oxford have found strong evidence that increased omega 3 fatty acid intake together with vitamin B supplements can markedly slow brain shrinkage atrophy and cognitive decline This project is an opportunity to develop a combination therapy to treat Age related cognitive decline such as MCI Aging population With ever improving healthcare life expectancy is increasing and as a result age related complications are becoming more common Mild Cognitive Impairment MCI is a recently recognised condition defined as cognitive decline greater than that expected for an individual s age and education level but that does not interfere notably with activities of daily life MCI affects around 16 of those over 70 years old and no proven therapy is currently available MCI is now clinically recognised as a strong risk factor for Alzheimer s disease about 50 of people diagnosed with MCI will develop Alzheimer s within 5 years of diagnosis Reducing brain atrophy A 2 year randomised clinical trial

    Original URL path: http://isis-innovation.com/licence-details/combination-therapy-to-slow-brain-atrophy/ (2016-05-01)
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  • Smart control of electrochemical energy storage - Isis Innovation
    Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Smart control of electrochemical energy storage Share this Smart control of electrochemical energy storage Batteries are ubiquitous From the smallest button batteries to the familiar AAA and AA batteries of innumerable toys and gadgets to the larger batteries in our mobile phone laptop and car we are all familiar with the value of using chemistry to store electrical energy Increasingly these off grid uses are being joined by grid connected applications where batteries are used to support the integration of green energy technologies within the grid Yet despite the familiarity and usefulness of batteries there remain some limitations e g different types of battery cannot easily be mixed a battery pack can fail when the state of health of only a single cell deteriorates Oxford researchers have created improved systems for managing cells within packs allowing different cell chemistries extending even to mixtures of batteries and super capacitors and states of health to be mixed offering improved performance and flexibility In addition to simulation and lab based testing looks like works like prototypes are being produced for field trials of these ideas E pluribus unum Batteries use a number of different chemistries such as lead acid or lithium ion and each has its own operating characteristics e g lithium ion batteries offer excellent performance but are unsafe if overcharged When a single storage cell is insufficient multiple identical cells are connected together to deliver the required electrical power e g a single laptop battery pack typically contains multiple lithium ion cells One significant problem with simply connecting multiple cells to form a single pack is that in the worst case the failure of one cell can lead to the replacement of the entire pack A study at Oxford of the capacity of lithium ion cells from failed laptop battery packs showed that the median cell capacity was still 71 of its nominal value From each according to its ability to each according to its needs Researchers at the University of Oxford have developed system and control algorithms that can combine cells of differing chemistries operating characteristics and capacities within a single energy storage system For example batteries and super capacitors can be mixed This approach offers a number of benefits Increased flexibility as technologies can mix and match within a single module pack

    Original URL path: http://isis-innovation.com/licence-details/smart-control-of-electrochemical-energy-storage/ (2016-05-01)
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  • Fluorogenic Oligonucleotide Combination Probes for Genetic Analysis and Cell Imaging - Isis Innovation
    for SMEs Material Reagent Sales Easy to use Materials Evaluation Agreement Investment Opportunities Technology investment opportunities Information for Investors Isis Innovation spinouts Oxford Invention Fund University of Oxford Isis Funds Oxford University Consulting Services Academic consulting advice Academic Expertise Showcases Technical Services Technical Services Showcases OUC Clients For University members Contact OUC Innovation Consultancy Technology Transfer Commercialisation Training Technology Transfer Services Technology Commercialisation Innovation Management Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Fluorogenic Oligonucleotide Combination Probes for Genetic Analysis and Cell Imaging Share this Fluorogenic Oligonucleotide Combination Probes for Genetic Analysis and Cell Imaging Novel fluorogenic multi colour oligonucleotide combination probes have been developed for DNA and RNA analysis which offer increased sensitivity and selectivity over currently used structures The Oxford combination probes possess both an intercalating fluorophore and reporter dye giving enhanced performance and improved discrimination in the detection of small RNAs disease related SNPs point mutations in DNA sequences and the presence of viral or bacterial infections The Importance of Sequencing Our understanding of the human genome and its relationship to health has been driven by major advances in DNA sequencing technology This knowledge has become indispensable in diverse fields such as medical diagnosis biotechnology forensic biology virology and biological systematics Improved methods for the analysis of specific target regions of DNA mRNA and small non coding RNAs are highly desirable and complementary to sequencing approaches Fluorogenic Probes Fluorescence based methods represent the state of the art and they offer high sensitivity widespread availability of instrumentation and ease of use Fluorogenic probes can provide sequence specific methods to detect a range of DNA and RNA targets They have particular utility in the detection of single nucleotide polymorphisms SNPs and point mutations as well as bacterial and viral infections When introduced to a target sequence the fluorogenic probe may form either a fully matched pair or in the presence of an SNP or point mutation a partially mismatched pair The detection system is based on the difference in physical properties of these bound and unbound pairs Sensitivity vs Selectivity Increased sensitivity can be obtained by increasing the difference in fluorescence between the bound and unbound probes This can be achieved by modifying the probes such that the brightness of the bound state is increased or the fluorescence of the unbound state is switched off Current probes incorporate multiple dye

    Original URL path: http://isis-innovation.com/licence-details/fluorogenic-oligonucleotide-combination-probes-for-genetic-analysis-and-cell-imaging/ (2016-05-01)
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  • Raman Activated Cell Ejection (RACE) - Isis Innovation
    Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Raman Activated Cell Ejection RACE Share this Raman Activated Cell Ejection RACE The ability to analyse single cells is of vital importance to the development of biotechnology Current methods for single cell isolation and analysis require the cells to be labelled potentially altering the natural state of each cell Techniques that support the identification and isolation of single cells of interest in their natural state represent a valuable tool for a range of applications Oxford researchers have developed a method that ensures single cells of interest can be identified from a natural medium using non invasive Raman Spectroscopy Cells of interest can therefore be identified and isolated for further study using a single instrument under sterile conditions The Frontier of Life Science and Biotechnology Cell biology is fundamental to the study of cancer stem cells genomics and the analyses of uncultured microorganisms Techniques that study bulk cells are disadvantageous as they average the behaviour of a large number of cells offering potentially misleading results The ability to study single cells the basic functional unit of life has huge implications for life science and medical research For these reasons the advent of single cell omics is expected to be a major growth area Current

    Original URL path: http://isis-innovation.com/licence-details/raman-activated-cell-ejection-race/ (2016-05-01)
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  • Protein team assembly for controlling cell signalling and catalysis - Isis Innovation
    SMEs Material Reagent Sales Easy to use Materials Evaluation Agreement Investment Opportunities Technology investment opportunities Information for Investors Isis Innovation spinouts Oxford Invention Fund University of Oxford Isis Funds Oxford University Consulting Services Academic consulting advice Academic Expertise Showcases Technical Services Technical Services Showcases OUC Clients For University members Contact OUC Innovation Consultancy Technology Transfer Commercialisation Training Technology Transfer Services Technology Commercialisation Innovation Management Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Protein team assembly for controlling cell signalling and catalysis Share this Protein team assembly for controlling cell signalling and catalysis SnoopTag Snoop Catcher is a genetically encoded peptide protein pair that reacts to form an irreversible isopeptide bond simply upon mixing This reaction makes it possible to link proteins into chains on a solid phase in a highly specific and efficient manner The method is simple to carry out modular and produces irreversibly linked and molecularly defined protein chains Proteins often work in teams and so this method creates the opportunity to either control or artificially generate such multi component systems Applications include regulating immune responses and cell differentiation or generation of antibody polymers for sensitive diagnostics multi enzyme assemblies to enhance metabolic flux and strong modular biomaterials SnoopTag Researchers at the University of Oxford recently developed a bacterial superglue known as SpyTag SpyCatcher from Streptococcus pyogenes They have now developed a new peptide protein pair named SnoopTag SnoopCatcher from Streptococcus pneumoniae which spontaneously locks together through a covalent bond SnoopTag SnoopCatcher reaction is high yielding and fast while the bond can survive extreme pH high ionic strength and detergents SnoopTag SnoopCatcher and SpyTag SpyCatcher are genetically encodable and are mutually unreactive so they allow many new opportunities for controlled and irreversible linkage of peptide and protein components By exploiting these peptide protein pairs together a modular and high yielding approach to irreversibly assemble proteins into chains has been developed Generating protein chains Solid phase synthesis which involves reactants bound to resin enabled a revolution in the generation of peptides and oligonucleotides to efficiently explore and control biological function However solid phase linkage for proteins is much more complex because of a large number of potential reactive groups present Previous methods only generated short protein chains because the methods give a range of undesired side products have weak linkages or use non genetically encoded components The key properties of

    Original URL path: http://isis-innovation.com/licence-details/protein-team-assembly-for-controlling-cell-signalling-and-catalysis/ (2016-05-01)
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  • Faces to paintings software suite - Isis Innovation
    Network Other Networks Isis Innovation in China Jobs Other Languages Contact us Technologies Available Explore Technologies for License Intellectual Property IP for SMEs Material Reagent Sales Easy to use Materials Evaluation Agreement Investment Opportunities Technology investment opportunities Information for Investors Isis Innovation spinouts Oxford Invention Fund University of Oxford Isis Funds Oxford University Consulting Services Academic consulting advice Academic Expertise Showcases Technical Services Technical Services Showcases OUC Clients For University members Contact OUC Innovation Consultancy Technology Transfer Commercialisation Training Technology Transfer Services Technology Commercialisation Innovation Management Case Study Overview Contact us Health Outcomes iOutcomes People Overview Clinical Outcomes Assessments Health Outcome Services FAQs Apply to Use Inspired Works Contact us Incubator News Incubator Services Stages of Development Our Ventures Meet the CEOs Find your CEO match Incubator Team Contact For University Members Consulting Services Support FAQs Register as a consultant Commercialising Your Technology IP patents and licences Starting a company FAQs Isis Startup Incubator Oxford University Hospital NHS Foundation Trust Translational Funding University Hot Desks For Medical Sciences Researchers Contact Us News Events Publications News Events Request further information Technology Showcase 2016 Success Stories Publications Annual Reports Innovation Insights Isis newsletters Comment opinion Other publications reports Home Technologies Available Technologies available for licensing Faces to paintings software suite Share this Faces to paintings software suite The software performs the task of matching photos of a person to similar looking people in paintings in order to retrieve paintings given a query photo This is challenging as paintings span many media oil ink watercolour and can vary tremendously in style caricature pop art minimalist and other elements such as angle lighting and size may vary Detecting similarities between a photo and a painting may be trivial for human eyes but poses a significant challenge for a computer The software utilises CNN face

    Original URL path: http://isis-innovation.com/licence-details/faces-to-paintings-software-suite/ (2016-05-01)
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