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  • VHL Maligne Hyperthermia - H746 : VHL
    skeletal muscle characterized by hypercarbia rhabdomyolysis generalized skeletal muscle contracture cardiac dysrhythmia and renal failure that develops on exposure to succinylcholine or volatile anesthetic agents Specific interventions including use of the calcium release channel antagonist dantrolene are efficacious in reversing signs of the canine syndrome Test specific information Age The disease may show itself on different ages in which it cannot be estimated when the first symptoms may show themselves Differences may exist between littermates and between breeds Throughput Normally the result can be expected within 10 working days This turn around time starts when both the sample and the fully filled out and signed submission form have been received Location of disease or trait This disease is present in the entire body but causes main effects in the internal organs such as stomach intestinal tract liver and or kidneys In a number of cases the disease affects one major internal organ Breed dependence For this test samples from all breeds are accepted Sample type For this DNA test we accept the following materials Blood EDTA Swab Blood Heparin Semen Tissue Please contact Dr Van Haeringen Laboratorium if you wish to submit other material as listed Result An animal can be free and has in that situation two healthy alleles When used in breeding this animal will not become ill due to the disease It cannot spread the disease in the population An animal can be carrier and has in that situation one healthy and one disease allele When used in breeding 50 percent of the offspring will receive the disease allele Carriers will also become ill An animal can be affected and has in that situation two disease alleles When used in breeding all offspring will also receive the disease allele Affected will also become ill Inheritance This genetic

    Original URL path: http://www.vhlgenetics.com/Webshop/TestDetails/tabid/259/ProdID/139/Language/en-US/CatID/6/Maligne_Hyperthermia.aspx (2016-02-12)
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  • VHL CA / Neuronal ceroid lipofuscinosis (NCL), 4A - H804 : VHL
    of the central nervous system The disease is caused by improper storage of energy in elements of cells lysosomes The disease usually appears between 3 and 5 years and includes tremors and a loss of balanced The disease progresses slowly the dog finding it increasingly difficult to walk In the final stages the dog is no longer able to move Test specific information Age Throughput Normally the result can be expected within 10 working days This turn around time starts when both the sample and the fully filled out and signed submission form have been received Location of disease or trait This disease leads to a loss of brain function Breed dependence This DNA test is available for the following breeds American Staffordshire Terrier AmStaff These breeds are listed because the mutation has been found in these breeds Additional information is available in the Frequently Asked Questions FAQ Sample type For this DNA test we accept the following materials Semen Blood EDTA Blood Heparin Tissue Swab Please contact Dr Van Haeringen Laboratorium if you wish to submit other material as listed Result An animal can be free and has in that situation two healthy alleles When used in breeding this animal will not become ill due to the disease It cannot spread the disease in the population An animal can be carrier and has in that situation one healthy and one disease allele When used in breeding 50 percent of the offspring will receive the disease allele Carriers will not become ill An animal can be affected and has in that situation two disease alleles When used in breeding all offspring will also receive the disease allele Affected will become ill Inheritance This genetic factor is inherited in an autosomal recessive mode This means that the individual can be free

    Original URL path: http://www.vhlgenetics.com/Webshop/TestDetails/tabid/259/ProdID/284/Language/en-US/CatID/6/CA__Neuronal_ceroid_lipofuscinosis_NCL_4A.aspx (2016-02-12)
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  • VHL MDR1 - H723 : VHL
    Routedescription Wageningen Routedescription Malle Belgium Webshop Animals Dog MDR1 H723 MDR1 Background The Multidrug Resistance gene 1 the MDR1 gene plays an important role in the barrier between blood capillaries and brain tissue Dogs suffering from oversensitivity for Ivermectine have been documented to be susceptible to neurotoxicity induced by many other drugs as well Test specific information Age The genetic factor is continuously present and will always be visible Throughput Normally the result can be expected within 10 working days This turn around time starts when both the sample and the fully filled out and signed submission form have been received Location of disease or trait This disease leads to a loss of brain function Breed dependence For this test samples from all breeds are accepted Sample type For this DNA test we accept the following materials Semen Blood EDTA Blood Heparin Tissue Swab Please contact Dr Van Haeringen Laboratorium if you wish to submit other material as listed Result An animal can be free and has in that situation two healthy alleles When used in breeding this animal will not become ill due to the disease It cannot spread the disease in the population An animal can be carrier and has in that situation one healthy and one disease allele When used in breeding 50 percent of the offspring will receive the disease allele Carriers will not become ill An animal can be affected and has in that situation two disease alleles When used in breeding all offspring will also receive the disease allele Affected will become ill Inheritance This genetic factor is inherited in an autosomal recessive mode This means that the individual can be free of the disease homozygote normal affected homozygous affected or carrier heterozygous Carriers may spread the mutation in a population without showing symptoms

    Original URL path: http://www.vhlgenetics.com/Webshop/TestDetails/tabid/259/ProdID/123/Language/en-US/CatID/6/MDR1.aspx (2016-02-12)
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